IGKC Gene

HGNC Family	Immunoglobulins (IG)
Name	immunoglobulin kappa constant
Description	Predicted to enable antigen binding activity. Involved in adaptive immune response. Located in blood microparticle and extracellular exosome. Part of IgG immunoglobulin complex. [provided by Alliance of Genome Resources, Mar 2025]
Synonyms	HCAK1, KM, IGKCD
Proteins	IGKC_HUMAN
NCBI Gene ID	3514
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

IGKC has 3,841 functional associations with biological entities spanning 7 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 41 datasets.

Click the + buttons to view associations for IGKC from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

IGKC Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of IGKC gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of IGKC gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of IGKC gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with IGKC protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with IGKC gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of IGKC gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of IGKC gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of IGKC gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing IGKC protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with IGKC gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with IGKC gene/protein from the curated CTD Gene-Disease Associations dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with IGKC gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DrugBank Drug Targets	interacting drugs for IGKC protein from the curated DrugBank Drug Targets dataset.
	GAD Gene-Disease Associations	diseases associated with IGKC gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with IGKC gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of IGKC gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with IGKC gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing IGKC from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of IGKC gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of IGKC gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of IGKC gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of IGKC gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	transcription factor perturbations changing expression of IGKC gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Viral Infections	virus perturbations changing expression of IGKC gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
	GlyGen Glycosylated Proteins	ligands (chemical) binding IGKC protein from the GlyGen Glycosylated Proteins dataset.
	GO Biological Process Annotations 2023	biological processes involving IGKC gene from the curated GO Biological Process Annotations 2023 dataset.
	GTEx Tissue-Specific Aging Signatures	tissue samples with high or low expression of IGKC gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset.
	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	cell lines with high or low expression of IGKC gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset.
	Hub Proteins Protein-Protein Interactions	interacting hub proteins for IGKC from the curated Hub Proteins Protein-Protein Interactions dataset.
	HuBMAP ASCT+B Augmented with RNA-seq Coexpression	cell types associated with IGKC gene from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset.
	HuBMAP Azimuth Cell Type Annotations	cell types associated with IGKC gene from the HuBMAP Azimuth Cell Type Annotations dataset.
	HuGE Navigator Gene-Phenotype Associations	phenotypes associated with IGKC gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of IGKC gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	MPO Gene-Phenotype Associations	phenotypes of transgenic mice caused by IGKC gene mutations from the MPO Gene-Phenotype Associations dataset.
	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	gene perturbations changing expression of IGKC gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
	OMIM Gene-Disease Associations	phenotypes associated with IGKC gene from the curated OMIM Gene-Disease Associations dataset.
	Pathway Commons Protein-Protein Interactions	interacting proteins for IGKC from the Pathway Commons Protein-Protein Interactions dataset.
	Reactome Pathways 2014	pathways involving IGKC protein from the Reactome Pathways dataset.
	Sanger Dependency Map Cancer Cell Line Proteomics	cell lines associated with IGKC protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset.
	TISSUES Curated Tissue Protein Expression Evidence Scores	tissues with high expression of IGKC protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset.
	TISSUES Text-mining Tissue Protein Expression Evidence Scores	tissues co-occuring with IGKC protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.