IGKV4-1 Gene

HGNC Family	Immunoglobulins (IG)
Name	immunoglobulin kappa variable 4-1
Description	Predicted to enable antigen binding activity. Predicted to be involved in immune response. Located in blood microparticle. [provided by Alliance of Genome Resources, Mar 2025]
Synonyms	IGKV41, B3
Proteins	KV401_HUMAN
NCBI Gene ID	28908
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

IGKV4-1 has 2,976 functional associations with biological entities spanning 5 categories (chemical, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 18 datasets.

Click the + buttons to view associations for IGKV4-1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

IGKV4-1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of IGKV4-1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of IGKV4-1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of IGKV4-1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with IGKV4-1 gene from the CellMarker Gene-Cell Type Associations dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of IGKV4-1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing IGKV4-1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing IGKV4-1 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of IGKV4-1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of IGKV4-1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of IGKV4-1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
	GTEx Tissue Gene Expression Profiles	tissues with high or low expression of IGKV4-1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
	GTEx Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of IGKV4-1 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
	GTEx Tissue-Specific Aging Signatures	tissue samples with high or low expression of IGKV4-1 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset.
	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	cell lines with high or low expression of IGKV4-1 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset.
	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of IGKV4-1 gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	Pathway Commons Protein-Protein Interactions	interacting proteins for IGKV4-1 from the Pathway Commons Protein-Protein Interactions dataset.
	Reactome Pathways 2014	pathways involving IGKV4-1 protein from the Reactome Pathways dataset.
	Sanger Dependency Map Cancer Cell Line Proteomics	cell lines associated with IGKV4-1 protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset.