IGLC1 Gene

HGNC Family	Immunoglobulins (IG)
Name	immunoglobulin lambda constant 1 (Mcg marker)
Description	Predicted to enable antigen binding activity. Predicted to be involved in immunoglobulin mediated immune response. Located in blood microparticle and extracellular exosome. [provided by Alliance of Genome Resources, Mar 2025]
Synonyms	IGLC
Proteins	LAC1_HUMAN
NCBI Gene ID	3537
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

IGLC1 has 1,094 functional associations with biological entities spanning 7 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 31 datasets.

Click the + buttons to view associations for IGLC1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

IGLC1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	CellMarker Gene-Cell Type Associations	cell types associated with IGLC1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of IGLC1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of IGLC1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing IGLC1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with IGLC1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with IGLC1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with IGLC1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DrugBank Drug Targets	interacting drugs for IGLC1 protein from the curated DrugBank Drug Targets dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of IGLC1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with IGLC1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing IGLC1 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of IGLC1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of IGLC1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of IGLC1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	transcription factor perturbations changing expression of IGLC1 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Viral Infections	virus perturbations changing expression of IGLC1 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
	GO Biological Process Annotations 2023	biological processes involving IGLC1 gene from the curated GO Biological Process Annotations 2023 dataset.
	GTEx Tissue Gene Expression Profiles	tissues with high or low expression of IGLC1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
	GTEx Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of IGLC1 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
	GTEx Tissue-Specific Aging Signatures	tissue samples with high or low expression of IGLC1 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset.
	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	cell lines with high or low expression of IGLC1 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset.
	HMDB Metabolites of Enzymes	interacting metabolites for IGLC1 protein from the curated HMDB Metabolites of Enzymes dataset.
	Hub Proteins Protein-Protein Interactions	interacting hub proteins for IGLC1 from the curated Hub Proteins Protein-Protein Interactions dataset.
	HuBMAP ASCT+B Augmented with RNA-seq Coexpression	cell types associated with IGLC1 gene from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset.
	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	cell lines with high or low copy number of IGLC1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
	MiRTarBase microRNA Targets	microRNAs targeting IGLC1 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset.
	MPO Gene-Phenotype Associations	phenotypes of transgenic mice caused by IGLC1 gene mutations from the MPO Gene-Phenotype Associations dataset.
	Pathway Commons Protein-Protein Interactions	interacting proteins for IGLC1 from the Pathway Commons Protein-Protein Interactions dataset.
	Reactome Pathways 2014	pathways involving IGLC1 protein from the Reactome Pathways dataset.
	TISSUES Experimental Tissue Protein Expression Evidence Scores	tissues with high expression of IGLC1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset.
	TISSUES Text-mining Tissue Protein Expression Evidence Scores	tissues co-occuring with IGLC1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.