IGLC3 Gene

HGNC Family	Immunoglobulins (IG)
Name	immunoglobulin lambda constant 3 (Kern-Oz+ marker)
Description	Predicted to enable antigen binding activity. Predicted to be involved in immunoglobulin mediated immune response. Located in blood microparticle and extracellular exosome. Part of IgG immunoglobulin complex. [provided by Alliance of Genome Resources, Mar 2025]
Proteins	LAC3_HUMAN
NCBI Gene ID	3539
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

IGLC3 has 751 functional associations with biological entities spanning 5 categories (functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 18 datasets.

Click the + buttons to view associations for IGLC3 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

IGLC3 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	CellMarker Gene-Cell Type Associations	cell types associated with IGLC3 gene from the CellMarker Gene-Cell Type Associations dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing IGLC3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with IGLC3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with IGLC3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with IGLC3 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing IGLC3 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of IGLC3 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	transcription factor perturbations changing expression of IGLC3 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
	GO Biological Process Annotations 2023	biological processes involving IGLC3 gene from the curated GO Biological Process Annotations 2023 dataset.
	GTEx Tissue Gene Expression Profiles	tissues with high or low expression of IGLC3 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
	GTEx Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of IGLC3 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
	GTEx Tissue-Specific Aging Signatures	tissue samples with high or low expression of IGLC3 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset.
	HuBMAP ASCT+B Augmented with RNA-seq Coexpression	cell types associated with IGLC3 gene from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset.
	HuBMAP Azimuth Cell Type Annotations	cell types associated with IGLC3 gene from the HuBMAP Azimuth Cell Type Annotations dataset.
	MiRTarBase microRNA Targets	microRNAs targeting IGLC3 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset.
	Pathway Commons Protein-Protein Interactions	interacting proteins for IGLC3 from the Pathway Commons Protein-Protein Interactions dataset.
	Reactome Pathways 2014	pathways involving IGLC3 protein from the Reactome Pathways dataset.
	TISSUES Text-mining Tissue Protein Expression Evidence Scores	tissues co-occuring with IGLC3 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.