IL13RA1 Gene

HGNC Family	CD molecules (CD), Interleukin receptors
Name	interleukin 13 receptor, alpha 1
Description	The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Interleukin‐13 receptor α1 (IL13RA1) is a key component of the type‐2 cytokine receptor system that mediates signals from both IL‑13 and, in combination with IL‑4Rα, IL‑4. Structural and mutagenesis studies have revealed that the N‐terminal (D1) domain of IL13RA1 forms a modular interface that is essential for the high‑affinity, selective recognition of IL‑13 without affecting IL‑4 binding."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In allergic diseases such as allergic rhinitis, IL13RA1 is directly targeted by microRNA‑143; suppression of IL13RA1 gene expression by miR‑143 subsequently reduces IL‑13–induced production of inflammatory cytokines and mucin in nasal epithelial cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In addition, inflammatory conditions modulate its expression in a tissue‐specific manner. For instance, lipopolysaccharide exposure increases IL13RA1 levels in retinal pigment epithelial cells, suggesting that upregulation of this receptor may contribute to inflammation‑associated cytotoxicity in the retina."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Genetic studies have further implicated IL13RA1 in pulmonary function; a single‐nucleotide polymorphism in the IL13RA1 gene was associated with lower lung function indices and an increased risk of chronic obstructive pulmonary disease in women."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Moreover, in the intestinal epithelium the PGD<sub>2</sub>–CRTH2 pathway down‑regulates IL13RA1 expression, thereby tempering IL‑13–driven effects such as epithelial cell proliferation and goblet cell hyperplasia during helminth infection."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In the cardiovascular system, IL13RA1 is expressed in myocardial tissue and appears to contribute to myocardial homeostasis, making it a potential therapeutic target in heart failure."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Furthermore, in the central nervous system, IL13RA1 is present on dopaminergic neurons of the substantia nigra where its expression increases vulnerability to oxidative stress–mediated damage, suggesting a role in the pathogenesis of neurodegenerative diseases such as Parkinson’s disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Takachika Ito, Shoichi Suzuki, Sachiko Kanaji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinct structural requirements for interleukin-4 (IL-4) and IL-13 binding to the shared IL-13 receptor facilitate cellular tuning of cytokine responsiveness."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.007286"}], "href": "https://doi.org/10.1074/jbc.M109.007286"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19586918"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19586918"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Michael Kraich, Markus Klein, Edwin Patiño, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1741-7007-4-13"}], "href": "https://doi.org/10.1186/1741-7007-4-13"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16640778"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16640778"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yaoshu Teng, Ruxin Zhang, Chunhui Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-143 inhibits interleukin-13-induced inflammatory cytokine and mucus production in nasal epithelial cells from allergic rhinitis patients by targeting IL13Rα1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2014.12.058"}], "href": "https://doi.org/10.1016/j.bbrc.2014.12.058"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25529447"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25529447"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Kar Wah Leung, Colin J Barnstable, Joyce Tombran-Tink "}, {"type": "b", "children": [{"type": "t", "text": "Bacterial endotoxin activates retinal pigment epithelial cells and induces their degeneration through IL-6 and IL-8 autocrine signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Immunol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molimm.2008.12.001"}], "href": "https://doi.org/10.1016/j.molimm.2008.12.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19157552"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19157552"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "B Beghé, I P Hall, S G Parker, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polymorphisms in IL13 pathway genes in asthma and chronic obstructive pulmonary disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Allergy (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1398-9995.2009.02167.x"}], "href": "https://doi.org/10.1111/j.1398-9995.2009.02167.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19796199"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19796199"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Oyebola O Oyesola, Michael T Shanahan, Matt Kanke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PGD2 and CRTH2 counteract Type 2 cytokine-elicited intestinal epithelial responses during helminth infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20202178"}], "href": "https://doi.org/10.1084/jem.20202178"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34283207"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34283207"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Uri Amit, David Kain, Allon Wagner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "New Role for Interleukin-13 Receptor α1 in Myocardial Homeostasis and Heart Failure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Heart Assoc (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/JAHA.116.005108"}], "href": "https://doi.org/10.1161/JAHA.116.005108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28528324"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28528324"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Brad E Morrison, Maria Cecilia Garibaldi Marcondes, Daniel K Nomura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cutting edge: IL-13Rα1 expression in dopaminergic neurons contributes to their oxidative stress-mediated loss following chronic peripheral treatment with lipopolysaccharide."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1102150"}], "href": "https://doi.org/10.4049/jimmunol.1102150"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23169588"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23169588"}]}]}]}
Synonyms	IL-13RA, CD213A1, NR4, CT19
Proteins	I13R1_HUMAN
NCBI Gene ID	3597
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

IL13RA1 has 7,128 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 128 datasets.

Click the + buttons to view associations for IL13RA1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

IL13RA1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of IL13RA1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of IL13RA1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of IL13RA1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of IL13RA1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of IL13RA1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of IL13RA1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of IL13RA1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of IL13RA1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of IL13RA1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of IL13RA1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of IL13RA1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of IL13RA1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with IL13RA1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with IL13RA1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of IL13RA1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of IL13RA1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of IL13RA1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of IL13RA1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing IL13RA1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing IL13RA1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing IL13RA1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with IL13RA1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with IL13RA1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of IL13RA1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with IL13RA1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with IL13RA1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with IL13RA1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of IL13RA1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by IL13RA1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with IL13RA1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with IL13RA1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with IL13RA1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with IL13RA1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at IL13RA1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of IL13RA1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of IL13RA1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing IL13RA1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with IL13RA1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with IL13RA1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of IL13RA1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.