Name | IMP (inosine 5'-monophosphate) dehydrogenase 2 |
Description | This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008] |
Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Inosine 5′‐monophosphate dehydrogenase type II (IMPDH2) is the rate‐limiting enzyme in the de novo synthesis of guanine nucleotides, making it essential for maintaining the intracellular GTP pool required for DNA replication, RNA transcription, and overall cellular proliferation. IMPDH2 is frequently upregulated and transcriptionally induced by oncogenic signals such as c‐Myc, thereby promoting S‐phase progression, tumor growth, and chemoresistance in a variety of cancers – including melanoma, colorectal cancer, glioblastoma, and prostate cancer."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": " Its expression can be further regulated by signaling cascades such as the PI3K/AKT/mTOR and p38 MAPK pathways, integrating IMPDH2 into broader networks that control cell cycle transitions and metabolic reprogramming."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}, {"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Under conditions of metabolic stress or upon pharmacologic inhibition—by agents like mycophenolic acid or ribavirin—IMPDH2 can assemble into distinct filamentous structures known as “rods and rings”. These supramolecular assemblies modify the enzyme’s sensitivity to feedback inhibition, thereby influencing nucleotide pool balance, cell cycle progression, and immunosuppressive responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Moreover, IMPDH2 serves as a nodal point in crosstalk between metabolism and cell motility; for instance, local IMPDH2 activity has been shown to regulate the activation of RAC1 in cell protrusions, linking purine metabolism to invasive behavior."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Genetic variability and somatic mutations in IMPDH2 yield functional consequences that can impact enzyme kinetics and stability. Such variants have been associated with differences in immunosuppressive drug responsiveness in transplant recipients"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "14"}]}, {"type": "t", "text": ", and emerging data even link rare deleterious mutations in IMPDH2 to neurological conditions such as dystonia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": " In addition, aberrant expression of IMPDH2 is increasingly recognized as a useful prognostic biomarker and a potential therapeutic target in diverse malignancies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}, {"type": "fg_fs", "start_ref": "17", "end_ref": "19"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies establish IMPDH2 as a multifaceted regulator that not only drives nucleotide biosynthesis and supports rapid cellular proliferation but also orchestrates critical responses to metabolic and pharmacologic stress. Through its integration with key signaling pathways and regulatory complexes, IMPDH2 influences tumor aggressiveness, immune modulation, and even aspects of neural development, thereby underscoring its importance as both a biomarker and a potential target for therapeutic intervention."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}, {"type": "fg_f", "ref": "10"}, {"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yen-Chun Liu, Feng Li, Jesse Handler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Global regulation of nucleotide biosynthetic genes by c-Myc."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0002722"}], "href": "https://doi.org/10.1371/journal.pone.0002722"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18628958"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18628958"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Sudha Mannava, Vladimir Grachtchouk, Linda J Wheeler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cc.6390"}], "href": "https://doi.org/10.4161/cc.6390"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18677108"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18677108"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Shiyu Duan, Wenqing Huang, Xiaoting Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IMPDH2 promotes colorectal cancer progression through activation of the PI3K/AKT/mTOR and PI3K/AKT/FOXO1 signaling pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-018-0980-3"}], "href": "https://doi.org/10.1186/s13046-018-0980-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30518405"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30518405"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Satoshi Kofuji, Akiyoshi Hirayama, Alexander Otto Eberhardt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41556-019-0363-9"}], "href": "https://doi.org/10.1038/s41556-019-0363-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31371825"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31371825"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "L Zhou, D Xia, J Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enhanced expression of IMPDH2 promotes metastasis and advanced tumor progression in patients with prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Transl Oncol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12094-014-1167-9"}], "href": "https://doi.org/10.1007/s12094-014-1167-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24659377"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24659377"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Daiki Karigane, Hiroshi Kobayashi, Takayuki Morikawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p38α Activates Purine Metabolism to Initiate Hematopoietic Stem/Progenitor Cell Cycling in Response to Stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Stem Cell (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.stem.2016.05.013"}], "href": "https://doi.org/10.1016/j.stem.2016.05.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27345838"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27345838"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "S John Calise, Wendy C Carcamo, Claire Krueger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glutamine deprivation initiates reversible assembly of mammalian rods and rings."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-014-1567-6"}], "href": "https://doi.org/10.1007/s00018-014-1567-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24477477"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24477477"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Pavel Juda, Jana Smigová, Lubomír Kováčik, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ultrastructure of cytoplasmic and nuclear inosine-5'-monophosphate dehydrogenase 2 \"rods and rings\" inclusions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Histochem Cytochem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1369/0022155414543853"}], "href": "https://doi.org/10.1369/0022155414543853"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24980853"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24980853"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Khian Hong Pua, Dylan T Stiles, Mathew E Sowa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IMPDH2 Is an Intracellular Target of the Cyclophilin A and Sanglifehrin A Complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2016.12.030"}], "href": "https://doi.org/10.1016/j.celrep.2016.12.030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28076787"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28076787"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Hongda Chen, Simone Werner, Julia Butt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prospective evaluation of 64 serum autoantibodies as biomarkers for early detection of colorectal cancer in a true screening setting."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.7500"}], "href": "https://doi.org/10.18632/oncotarget.7500"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26909861"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26909861"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Jian Wang, Adriana Zeevi, Steve Webber, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel variant L263F in human inosine 5'-monophosphate dehydrogenase 2 is associated with diminished enzyme activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacogenet Genomics (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/FPC.0b013e328012b8cf"}], "href": "https://doi.org/10.1097/FPC.0b013e328012b8cf"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17496727"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17496727"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Olivier Gensburger, Ron H N Van Schaik, Nicolas Picard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polymorphisms in type I and II inosine monophosphate dehydrogenase genes and association with clinical outcome in patients on mycophenolate mofetil."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacogenet Genomics (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/FPC.0b013e32833d8cf5"}], "href": "https://doi.org/10.1097/FPC.0b013e32833d8cf5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20679962"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20679962"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "W Winnicki, G Weigel, G Sunder-Plassmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An inosine 5'-monophosphate dehydrogenase 2 single-nucleotide polymorphism impairs the effect of mycophenolic acid."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacogenomics J (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/tpj.2009.43"}], "href": "https://doi.org/10.1038/tpj.2009.43"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19770842"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19770842"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "T-Y Wu, Y Peng, L L Pelleymounter, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pharmacogenetics of the mycophenolic acid targets inosine monophosphate dehydrogenases IMPDH1 and IMPDH2: gene sequence variation and functional genomics."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Pharmacol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1476-5381.2010.00987.x"}], "href": "https://doi.org/10.1111/j.1476-5381.2010.00987.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20718729"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20718729"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jonathan I Lake, Marina Avetisyan, Albert G Zimmermann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neural crest requires Impdh2 for development of the enteric nervous system, great vessels, and craniofacial skeleton."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2015.11.004"}], "href": "https://doi.org/10.1016/j.ydbio.2015.11.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26546974"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26546974"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Anna Kuukasjärvi, Juan C Landoni, Jyrki Kaukonen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IMPDH2: a new gene associated with dominant juvenile-onset dystonia-tremor disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41431-021-00939-1"}], "href": "https://doi.org/10.1038/s41431-021-00939-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34305140"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34305140"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Jun Zou, Zhaodong Han, Liang Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elevated expression of IMPDH2 is associated with progression of kidney and bladder cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Oncol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12032-014-0373-1"}], "href": "https://doi.org/10.1007/s12032-014-0373-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25465060"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25465060"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "F Vannozzi, F Filipponi, A Di Paolo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An exploratory study on pharmacogenetics of inosine-monophosphate dehydrogenase II in peripheral mononuclear cells from liver-transplant recipients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transplant Proc (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.transproceed.2004.09.070"}], "href": "https://doi.org/10.1016/j.transproceed.2004.09.070"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15621150"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15621150"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Mutsumi Kudo, Yuka Saito, Takamitsu Sasaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variations in the HGPRT, ITPA, IMPDH1, IMPDH2, and GMPS genes in Japanese individuals."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Drug Metab Pharmacokinet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2133/dmpk.24.557"}], "href": "https://doi.org/10.2133/dmpk.24.557"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20045992"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20045992"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Qi Zhang, Xiang Zhou, RuiZhi Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role of IMP dehydrogenase 2 in Inauhzin-induced ribosomal stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.03077"}], "href": "https://doi.org/10.7554/eLife.03077"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25347121"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25347121"}]}]}]}
|
Synonyms | IMPDH-II, IMPD2 |
Proteins | IMDH2_HUMAN |
NCBI Gene ID | 3615 |
API | |
Download Associations | |
Predicted Functions |
![]() |
Co-expressed Genes |
![]() |
Expression in Tissues and Cell Lines |
![]() |
IMPDH2 has 11,158 functional associations with biological entities spanning 8 categories (molecular profile, organism, disease, phenotype or trait, functional term, phrase or reference, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 123 datasets.
Click the + buttons to view associations for IMPDH2 from the datasets below.
If available, associations are ranked by standardized value
Dataset | Summary | |
---|---|---|
Achilles Cell Line Gene Essentiality Profiles | cell lines with fitness changed by IMPDH2 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset. | |
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of IMPDH2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of IMPDH2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of IMPDH2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of IMPDH2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of IMPDH2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of IMPDH2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of IMPDH2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of IMPDH2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of IMPDH2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
CCLE Cell Line Proteomics | Cell lines associated with IMPDH2 protein from the CCLE Cell Line Proteomics dataset. | |
CellMarker Gene-Cell Type Associations | cell types associated with IMPDH2 gene from the CellMarker Gene-Cell Type Associations dataset. | |
ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of IMPDH2 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
ChEA Transcription Factor Targets | transcription factors binding the promoter of IMPDH2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of IMPDH2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
ClinVar Gene-Phenotype Associations | phenotypes associated with IMPDH2 gene from the curated ClinVar Gene-Phenotype Associations dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing IMPDH2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing IMPDH2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 | cellular components containing IMPDH2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with IMPDH2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with IMPDH2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of IMPDH2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
COSMIC Cell Line Gene Mutation Profiles | cell lines with IMPDH2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
CTD Gene-Chemical Interactions | chemicals interacting with IMPDH2 gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
CTD Gene-Disease Associations | diseases associated with IMPDH2 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with IMPDH2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with IMPDH2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with IMPDH2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DisGeNET Gene-Disease Associations | diseases associated with IMPDH2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
DisGeNET Gene-Phenotype Associations | phenotypes associated with IMPDH2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
DrugBank Drug Targets | interacting drugs for IMPDH2 protein from the curated DrugBank Drug Targets dataset. | |
ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at IMPDH2 gene from the ENCODE Histone Modification Site Profiles dataset. | |
ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of IMPDH2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
ENCODE Transcription Factor Targets | transcription factors binding the promoter of IMPDH2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing IMPDH2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
GAD Gene-Disease Associations | diseases associated with IMPDH2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
GAD High Level Gene-Disease Associations | diseases associated with IMPDH2 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of IMPDH2 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
GeneRIF Biological Term Annotations | biological terms co-occuring with IMPDH2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing IMPDH2 from the GeneSigDB Published Gene Signatures dataset. | |
GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of IMPDH2 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of IMPDH2 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of IMPDH2 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of IMPDH2 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of IMPDH2 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of IMPDH2 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
GO Biological Process Annotations 2015 | biological processes involving IMPDH2 gene from the curated GO Biological Process Annotations 2015 dataset. | |
GO Biological Process Annotations 2023 | biological processes involving IMPDH2 gene from the curated GO Biological Process Annotations 2023 dataset. | |
GO Biological Process Annotations 2025 | biological processes involving IMPDH2 gene from the curated GO Biological Process Annotations2025 dataset. | |
GO Cellular Component Annotations 2015 | cellular components containing IMPDH2 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
GO Cellular Component Annotations 2023 | cellular components containing IMPDH2 protein from the curated GO Cellular Component Annotations 2023 dataset. | |
GO Cellular Component Annotations 2025 | cellular components containing IMPDH2 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
GO Molecular Function Annotations 2015 | molecular functions performed by IMPDH2 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
GO Molecular Function Annotations 2023 | molecular functions performed by IMPDH2 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
GO Molecular Function Annotations 2025 | molecular functions performed by IMPDH2 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
GTEx Tissue Gene Expression Profiles | tissues with high or low expression of IMPDH2 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of IMPDH2 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of IMPDH2 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of IMPDH2 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
Guide to Pharmacology Chemical Ligands of Receptors | ligands (chemical) binding IMPDH2 receptor from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset. | |
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of IMPDH2 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
HMDB Metabolites of Enzymes | interacting metabolites for IMPDH2 protein from the curated HMDB Metabolites of Enzymes dataset. | |
HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of IMPDH2 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
HPA Tissue Gene Expression Profiles | tissues with high or low expression of IMPDH2 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
HPA Tissue Protein Expression Profiles | tissues with high or low expression of IMPDH2 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of IMPDH2 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
Hub Proteins Protein-Protein Interactions | interacting hub proteins for IMPDH2 from the curated Hub Proteins Protein-Protein Interactions dataset. | |
HuGE Navigator Gene-Phenotype Associations | phenotypes associated with IMPDH2 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
HumanCyc Pathways | pathways involving IMPDH2 protein from the HumanCyc Pathways dataset. | |
InterPro Predicted Protein Domain Annotations | protein domains predicted for IMPDH2 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of IMPDH2 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
KEA Substrates of Kinases | kinases that phosphorylate IMPDH2 protein from the curated KEA Substrates of Kinases dataset. | |
KEGG Pathways | pathways involving IMPDH2 protein from the KEGG Pathways dataset. | |
Kinase Library Serine Threonine Kinome Atlas | kinases that phosphorylate IMPDH2 protein from the Kinase Library Serine Threonine Atlas dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of IMPDH2 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of IMPDH2 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with IMPDH2 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of IMPDH2 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of IMPDH2 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of IMPDH2 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of IMPDH2 gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain IMPDH2 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by IMPDH2 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
MiRTarBase microRNA Targets | microRNAs targeting IMPDH2 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of IMPDH2 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of IMPDH2 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by IMPDH2 gene mutations from the MPO Gene-Phenotype Associations dataset. | |
MSigDB Cancer Gene Co-expression Modules | co-expressed genes for IMPDH2 from the MSigDB Cancer Gene Co-expression Modules dataset. | |
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of IMPDH2 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
NURSA Protein Complexes | protein complexs containing IMPDH2 protein recovered by IP-MS from the NURSA Protein Complexes dataset. | |
OMIM Gene-Disease Associations | phenotypes associated with IMPDH2 gene from the curated OMIM Gene-Disease Associations dataset. | |
PANTHER Pathways | pathways involving IMPDH2 protein from the PANTHER Pathways dataset. | |
Pathway Commons Protein-Protein Interactions | interacting proteins for IMPDH2 from the Pathway Commons Protein-Protein Interactions dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of IMPDH2 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of IMPDH2 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PFOCR Pathway Figure Associations 2023 | pathways involving IMPDH2 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
PFOCR Pathway Figure Associations 2024 | pathways involving IMPDH2 protein from the Wikipathways PFOCR 2024 dataset. | |
PhosphoSitePlus Substrates of Kinases | kinases that phosphorylate IMPDH2 protein from the curated PhosphoSitePlus Substrates of Kinases dataset. | |
ProteomicsDB Cell Type and Tissue Protein Expression Profiles | cell types and tissues with high or low expression of IMPDH2 protein relative to other cell types and tissues from the ProteomicsDB Cell Type and Tissue Protein Expression Profiles dataset. | |
Reactome Pathways 2014 | pathways involving IMPDH2 protein from the Reactome Pathways dataset. | |
Reactome Pathways 2024 | pathways involving IMPDH2 protein from the Reactome Pathways 2024 dataset. | |
Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of IMPDH2 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of IMPDH2 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset. | |
Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of IMPDH2 gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of IMPDH2 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at IMPDH2 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of IMPDH2 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of IMPDH2 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
Sanger Dependency Map Cancer Cell Line Proteomics | cell lines associated with IMPDH2 protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset. | |
SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs | drug perturbations changing phosphorylation of IMPDH2 protein from the SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs dataset. | |
SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Protein Ligands | ligand (protein) perturbations changing phosphorylation of IMPDH2 protein from the SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Protein Ligands dataset. | |
TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of IMPDH2 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of IMPDH2 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of IMPDH2 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of IMPDH2 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of IMPDH2 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of IMPDH2 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with IMPDH2 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with IMPDH2 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
Virus MINT Protein-Viral Protein Interactions | interacting viral proteins for IMPDH2 from the Virus MINT Protein-Viral Protein Interactions dataset. | |
Virus MINT Protein-Virus Interactions | viruses interacting with IMPDH2 from the Virus MINT Protein-Virus Interactions dataset. | |
WikiPathways Pathways 2014 | pathways involving IMPDH2 protein from the Wikipathways Pathways 2014 dataset. | |
WikiPathways Pathways 2024 | pathways involving IMPDH2 protein from the WikiPathways Pathways 2024 dataset. | |