{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n INO80C is an evolutionarily conserved, ATP‐dependent chromatin remodeling complex that plays multifaceted roles in the regulation of chromatin structure, gene expression, and genome stability. Structural and biochemical studies have revealed that the complex is organized around a central Ino80 ATPase that assembles into distinct functional modules with associated AAA+ proteins (e.g. RUVBL1/2), actin‐related proteins, and transcription regulators such as YY1, thereby driving nucleosome sliding and remodeling (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " In embryonic stem cells, INO80C is essential for maintaining pluripotency by co‐occupying promoters with master transcription factors, sustaining an open chromatin architecture and licensing the recruitment of Mediator and RNA polymerase II to drive gene activation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In addition, specific subunits of the INO80C complex, such as Arp8, function as nucleosome recognition modules, thereby targeting the complex to appropriate chromatin regions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " INO80C also contributes to genome homeostasis by suppressing pervasive transcription at replication origins and by facilitating the repair of DNA double-strand breaks; in the context of homologous recombination, for example, its interplay with the histone variant H2A.Z is critical for enabling presynaptic filament formation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Moreover, the INO80/YY1 sub-complex regulates target gene expression—such as that of BCCIP—and studies in yeast have underscored its additional roles in transcriptional control and chromatin dynamics."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Finally, by influencing pericentric chromatin structure and the proper incorporation of histone variants, INO80C activity is also linked to accurate chromosome segregation and overall genomic stability."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Collectively, these studies highlight INO80C as a central regulator that integrates chromatin remodeling with transcriptional control and DNA repair to ensure proper cellular function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}, {"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lu Chen, Yong Cai, Jingji Jin, et al. 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