INPP5A Gene

Name	inositol polyphosphate-5-phosphatase, 40kDa
Description	The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Inositol polyphosphate-5‐phosphatase A (INPP5A) is emerging as a critical regulator of inositol signaling by dephosphorylating specific phosphoinositides, thereby modulating intracellular calcium dynamics and downstream cellular processes. INPP5A plays an essential role in the nervous system where its proper expression is necessary for the survival and function of cerebellar Purkinje cells. Loss or transcriptional downregulation of INPP5A—as observed in mouse models with early‐onset Purkinje cell degeneration and in spinocerebellar ataxia type 17—leads to disrupted calcium homeostasis, impaired dendritic arborization, and ultimately neurodegeneration and motor ataxia."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Outside the nervous system, reduced expression of INPP5A has been linked to tumorigenesis. In cutaneous squamous cell carcinoma and esophageal squamous cell carcinoma, frequent deletions or diminished protein levels of INPP5A are associated with early tumor development, progression, and metastasis, suggesting that INPP5A functions as a tumor suppressor through its negative regulation of inositol-mediated signaling cascades."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, INPP5A contributes to broader aspects of cellular homeostasis; by modulating the inositol phosphate pool, it influences calcium release from intracellular stores, which in turn impacts lysosome biogenesis via nuclear translocation of TFEB/TFE3."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In addition, genomic alterations involving INPP5A—such as a microduplication found in individuals with schizophrenia spectrum disorders—underline its importance in maintaining proper neuronal calcium signaling and dendritic spine morphogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies highlight that INPP5A is not only central to calcium signaling and phosphoinositide metabolism in neurons but also serves as a pivotal modulator of cell proliferation and survival in various tissues. Its dysregulation has significant implications for neurodegenerative diseases and certain cancers, thereby positioning INPP5A as a promising target for therapeutic intervention.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Andy W Yang, Andrew J Sachs, Arne M Nystuen "}, {"type": "b", "children": [{"type": "t", "text": "Deletion of Inpp5a causes ataxia and cerebellar degeneration in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurogenetics (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10048-015-0450-4"}], "href": "https://doi.org/10.1007/s10048-015-0450-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26051944"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26051944"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Qiong Liu, Shanshan Huang, Peng Yin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cerebellum-enriched protein INPP5A contributes to selective neuropathology in mouse model of spinocerebellar ataxias type 17."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-020-14931-8"}], "href": "https://doi.org/10.1038/s41467-020-14931-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32107387"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32107387"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jian-Wei Zhu, Wei-Qiang Jia, Hui Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deficiency of TRIM32 Impairs Motor Function and Purkinje Cells in Mid-Aged Mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Aging Neurosci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fnagi.2021.697494"}], "href": "https://doi.org/10.3389/fnagi.2021.697494"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34421574"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34421574"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Aleksandar Sekulic, Su Y Kim, Galen Hostetter, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of inositol polyphosphate 5-phosphatase is an early event in development of cutaneous squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Prev Res (Phila) (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1940-6207.CAPR-10-0058"}], "href": "https://doi.org/10.1158/1940-6207.CAPR-10-0058"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20876729"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20876729"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Fatemeh Fardi Golyan, Mohammad Mahdi Forghanifard "}, {"type": "b", "children": [{"type": "t", "text": "A new gene panel as a marker for ESCC poor prognosis; INPP5A, TWIST1, MMP2, and EGFR."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Adv Med Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.advms.2021.03.004"}], "href": "https://doi.org/10.1016/j.advms.2021.03.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33798953"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33798953"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Mouhannad Malek, Anna M Wawrzyniak, Michael Ebner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inositol triphosphate-triggered calcium release from the endoplasmic reticulum induces lysosome biogenesis via TFEB/TFE3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jbc.2022.101740"}], "href": "https://doi.org/10.1016/j.jbc.2022.101740"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35182526"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35182526"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Arnaud Fernandez, Małgorzata Drozd, Susanne Thümmler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel microduplication in INPP5A segregates with schizophrenia spectrum disorder in the family of a patient with both childhood onset schizophrenia and autism spectrum disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.62155"}], "href": "https://doi.org/10.1002/ajmg.a.62155"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33720513"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33720513"}]}]}]}
Synonyms	5PTASE
Proteins	I5P1_HUMAN
NCBI Gene ID	3632
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

INPP5A has 6,345 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 122 datasets.

Click the + buttons to view associations for INPP5A from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

INPP5A Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by INPP5A gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of INPP5A gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of INPP5A gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of INPP5A gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of INPP5A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of INPP5A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of INPP5A gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of INPP5A gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of INPP5A gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of INPP5A gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of INPP5A gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of INPP5A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of INPP5A gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with INPP5A protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of INPP5A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of INPP5A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of INPP5A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing INPP5A protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of INPP5A gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing INPP5A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing INPP5A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with INPP5A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with INPP5A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of INPP5A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with INPP5A gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with INPP5A gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with INPP5A gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of INPP5A protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by INPP5A gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with INPP5A gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with INPP5A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with INPP5A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with INPP5A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with INPP5A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at INPP5A gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of INPP5A gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of INPP5A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing INPP5A from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of INPP5A gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with INPP5A gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.