IPMK Gene

Name	inositol polyphosphate multikinase
Description	This gene encodes a member of the inositol phosphokinase family. The encoded protein has 3-kinase, 5-kinase and 6-kinase activities on phosphorylated inositol substrates. The encoded protein plays an important role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate, and has a preferred 5-kinase activity. This gene may play a role in nuclear mRNA export. Pseudogenes of this gene are located on the long arm of chromosome 13 and the short arm of chromosome 19. [provided by RefSeq, Dec 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Inositol polyphosphate multikinase (IPMK) is a versatile enzyme that functions both catalytically and non‐catalytically to integrate multiple cellular signaling pathways. Its kinase activities generate water‐soluble inositol polyphosphates as well as the lipid messenger phosphatidylinositol 3,4,5‐trisphosphate (PIP3), thereby regulating growth factor responses and Akt signaling to control cell proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the nucleus, IPMK phosphorylates phosphatidylinositol 4,5‐bisphosphate when bound to nuclear receptors such as SF‐1, remodeling its ligand and modulating transcriptional programs."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, IPMK facilitates transcript‐selective mRNA export by ensuring proper recognition of specific mRNAs (e.g., RAD51) by export factors, thus contributing to genome integrity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its catalytic functions, IPMK engages in key protein–protein interactions. It regulates cellular energy homeostasis by directly binding to metabolic sensors such as AMPK and LKB1, a process that underlies its role in mediating responses to metabolic cues and drugs like metformin."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In addition, IPMK acts as a transcriptional coactivator independently of its kinase activity by interacting with factors including p53 and serum response factor (SRF), thereby enhancing the expression of stress‐responsive and immediate early genes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n IPMK further contributes to cellular quality control by modulating autophagy through the formation of complexes with AMPK, Sirt1, and ULK, which has implications in liver inflammation and regeneration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Its role extends to developmental signaling pathways; for example, in Wnt signaling, IPMK translocates to the plasma membrane by complexing with Dishevelled proteins to promote canonical pathway activation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ", and it supports myogenic differentiation by enhancing β‐catenin nuclear accumulation and cyclin D3 induction."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, regulated nucleocytoplasmic shuttling of IPMK—which is modulated by phosphorylation events—ensures that its activities are appropriately localized, while genetic variants affecting IPMK have been linked to neurodegenerative disorders, altered synaptic gene expression, and longevity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "14"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies underscore IPMK as a multifunctional regulator that integrates phosphoinositide signaling, transcriptional control, mRNA export, metabolic homeostasis, and developmental programs—a central hub in both normal physiology and disease pathogenesis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "David Maag, Micah J Maxwell, Douglas A Hardesty, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1017831108"}], "href": "https://doi.org/10.1073/pnas.1017831108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21220345"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21220345"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Marcus M Nalaskowski, Christina Deschermeier, Werner Fanick, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20020327"}], "href": "https://doi.org/10.1042/BJ20020327"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12027805"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12027805"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Raymond D Blind, Miyuki Suzawa, Holly A Ingraham "}, {"type": "b", "children": [{"type": "t", "text": "Direct modification and activation of a nuclear receptor-PIP₂ complex by the inositol lipid kinase IPMK."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.2003111"}], "href": "https://doi.org/10.1126/scisignal.2003111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22715467"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22715467"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Vihandha O Wickramasinghe, Jane M Savill, Sreenivas Chavali, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human inositol polyphosphate multikinase regulates transcript-selective nuclear mRNA export to preserve genome integrity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2013.08.031"}], "href": "https://doi.org/10.1016/j.molcel.2013.08.031"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24074953"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24074953"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Sookhee Bang, Seyun Kim, Megan J Dailey, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AMP-activated protein kinase is physiologically regulated by inositol polyphosphate multikinase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1119751109"}], "href": "https://doi.org/10.1073/pnas.1119751109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22203993"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22203993"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Sookhee Bang, Yong Chen, Rexford S Ahima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Convergence of IPMK and LKB1-AMPK signaling pathways on metformin action."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2014-1134"}], "href": "https://doi.org/10.1210/me.2014-1134"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24877601"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24877601"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Eunha Kim, Richa Tyagi, Joo-Young Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inositol polyphosphate multikinase is a coactivator for serum response factor-dependent induction of immediate early genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1320171110"}], "href": "https://doi.org/10.1073/pnas.1320171110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24248338"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24248338"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Risheng Xu, Bindu D Paul, Dani R Smith, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inositol polyphosphate multikinase is a transcriptional coactivator required for immediate early gene induction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1315551110"}], "href": "https://doi.org/10.1073/pnas.1315551110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24043835"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24043835"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Prasun Guha, Richa Tyagi, Sayan Chowdhury, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IPMK Mediates Activation of ULK Signaling and Transcriptional Regulation of Autophagy Linked to Liver Inflammation and Regeneration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2019.02.013"}], "href": "https://doi.org/10.1016/j.celrep.2019.02.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30840891"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30840891"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Ying Wang, Hsien-yu Wang "}, {"type": "b", "children": [{"type": "t", "text": "Dvl3 translocates IPMK to the cell membrane in response to Wnt."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2012.08.009"}], "href": "https://doi.org/10.1016/j.cellsig.2012.08.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22940627"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22940627"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Giulia Ramazzotti, Anna Maria Billi, Lucia Manzoli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IPMK and β-catenin mediate PLC-β1-dependent signaling in myogenic differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.11527"}], "href": "https://doi.org/10.18632/oncotarget.11527"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27563828"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27563828"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Rüdiger Meyer, Marcus M Nalaskowski, Patrick Ehm, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nucleocytoplasmic shuttling of human inositol phosphate multikinase is influenced by CK2 phosphorylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1515/hsz-2011-0209"}], "href": "https://doi.org/10.1515/hsz-2011-0209"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22718630"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22718630"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Serena Dato, Paolina Crocco, Francesco De Rango, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IP6K3 and IPMK variations in LOAD and longevity: Evidence for a multifaceted signaling network at the crossroad between neurodegeneration and survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mech Ageing Dev (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mad.2021.111439"}], "href": "https://doi.org/10.1016/j.mad.2021.111439"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33497757"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33497757"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Jina Park, Seung Ju Park, Seyun Kim "}, {"type": "b", "children": [{"type": "t", "text": "Inositol polyphosphate multikinase deficiency leads to aberrant induction of synaptotagmin-2 in the forebrain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Brain (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13041-019-0480-1"}], "href": "https://doi.org/10.1186/s13041-019-0480-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31221192"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31221192"}]}]}]}
Proteins	IPMK_HUMAN
NCBI Gene ID	253430
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

IPMK has 5,107 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 113 datasets.

Click the + buttons to view associations for IPMK from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

IPMK Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by IPMK gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of IPMK gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of IPMK gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of IPMK gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of IPMK gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of IPMK gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of IPMK gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of IPMK gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of IPMK gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of IPMK gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with IPMK gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of IPMK gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of IPMK gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of IPMK gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing IPMK protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing IPMK protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing IPMK protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with IPMK protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with IPMK protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of IPMK gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with IPMK gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with IPMK gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with IPMK gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of IPMK protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by IPMK gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with IPMK gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with IPMK gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with IPMK gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with IPMK gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with IPMK gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with IPMK gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at IPMK gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of IPMK gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of IPMK gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing IPMK from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with IPMK gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with IPMK gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing IPMK from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of IPMK gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of IPMK gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.