IPO13 Gene

HGNC Family	Importins (IPO)
Name	importin 13
Description	This gene encodes a member of the importin-beta family of nuclear transport proteins. The encoded protein mediates the import of specific cargo proteins from the cytoplasm to the nucleus and is dependent on the Ras-related nuclear protein-GTPase system. The encoded protein is also involved in nuclear export of the eukaryotic translation initiation factor 1A.[provided by RefSeq, Mar 2009]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Importin‐13 (IPO13) is a versatile, bidirectional member of the importin‐β family that plays a critical role in nucleocytoplasmic transport across diverse cell types and developmental contexts. IPO13 mediates the nuclear import of a variety of cargoes—including key transcription factors such as the glucocorticoid receptor (GR) and the homeodomain protein ARX—which is essential for proper anti‐inflammatory signaling and transcriptional regulation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " Structural and functional analyses further reveal that IPO13 also serves as an export receptor for specific substrates such as the translation initiation factor eIF1A, highlighting its dual role in both import and export."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Moreover, IPO13 is intimately involved in developmental processes: mutations in IPO13 have been linked to ocular abnormalities including coloboma, microphthalmia, and cataract"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", and alterations in its expression impact progenitor cell function in tissues such as testis, brain, and corneal epithelium."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In addition, IPO13 modulates cellular stress responses by mediating the nuclear export of transcription factors like SP1 and KLF4, thereby influencing stress and apoptotic signaling pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Finally, its ability to function as an alternative import pathway for multiprotein complexes—as demonstrated by its role in nuclear import of the NC2 complex—underscores its broad regulatory potential in gene expression and cellular homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Collectively, these findings establish IPO13 as a crucial regulator of nucleocytoplasmic trafficking with significant implications for signaling, development, and disease.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tao Tao, Jie Lan, Gergely L Lukacs, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Importin 13 regulates nuclear import of the glucocorticoid receptor in airway epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Respir Cell Mol Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1165/rcmb.2006-0073OC"}], "href": "https://doi.org/10.1165/rcmb.2006-0073OC"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16809634"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16809634"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Cheryl Shoubridge, Desiree Cloosterman, Emma Parkinson-Lawerence, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular pathology of expanded polyalanine tract mutations in the Aristaless-related homeobox gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genomics (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ygeno.2007.03.005"}], "href": "https://doi.org/10.1016/j.ygeno.2007.03.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17490853"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17490853"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Benjamin A Raby, Kristel Van Steen, Jessica Lasky-Su, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Importin-13 genetic variation is associated with improved airway responsiveness in childhood asthma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Respir Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1465-9921-10-67"}], "href": "https://doi.org/10.1186/1465-9921-10-67"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19619331"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19619331"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Marlene Grünwald, Daniela Lazzaretti, Fulvia Bono "}, {"type": "b", "children": [{"type": "t", "text": "Structural basis for the nuclear export activity of Importin13."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emboj.2013.29"}], "href": "https://doi.org/10.1038/emboj.2013.29"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23435562"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23435562"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xiu-Feng Huang, Lue Xiang, Wan Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutation of IPO13 causes recessive ocular coloboma, microphthalmia, and cataract."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Mol Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s12276-018-0079-0"}], "href": "https://doi.org/10.1038/s12276-018-0079-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29700284"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29700284"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Shadma Fatima, Kylie M Wagstaff, Kim G Lieu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interactome of the inhibitory isoform of the nuclear transporter Importin 13."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Mol Cell Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2016.12.017"}], "href": "https://doi.org/10.1016/j.bbamcr.2016.12.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27993670"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27993670"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Pan You, Zi Peng, Yiwei Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression and subcellular distribution of imp13 are regulated in brain development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "In Vitro Cell Dev Biol Anim (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11626-013-9599-z"}], "href": "https://doi.org/10.1007/s11626-013-9599-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23605716"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23605716"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "K A Gajewska, H Lescesen, M Ramialison, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear transporter Importin-13 plays a key role in the oxidative stress transcriptional response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-021-26125-x"}], "href": "https://doi.org/10.1038/s41467-021-26125-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34625540"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34625540"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Joerg Kahle, Elisa Piaia, Sonja Neimanis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of nuclear import and export of negative cofactor 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M805694200"}], "href": "https://doi.org/10.1074/jbc.M805694200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19204005"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19204005"}]}]}]}
Synonyms	RANBP13, KAP13, IMP13
Proteins	IPO13_HUMAN
NCBI Gene ID	9670
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

IPO13 has 8,217 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 109 datasets.

Click the + buttons to view associations for IPO13 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

IPO13 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of IPO13 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of IPO13 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of IPO13 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of IPO13 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of IPO13 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of IPO13 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of IPO13 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of IPO13 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of IPO13 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of IPO13 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of IPO13 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of IPO13 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with IPO13 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with IPO13 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of IPO13 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of IPO13 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of IPO13 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of IPO13 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing IPO13 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing IPO13 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with IPO13 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with IPO13 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing IPO13 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of IPO13 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with IPO13 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with IPO13 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with IPO13 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of IPO13 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with IPO13 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with IPO13 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with IPO13 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with IPO13 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with IPO13 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at IPO13 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of IPO13 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of IPO13 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing IPO13 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with IPO13 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with IPO13 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of IPO13 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.