IRAK1 Gene

Name	interleukin-1 receptor-associated kinase 1
Description	This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Interleukin‐1 receptor-associated kinase 1 (IRAK1) is a serine/threonine kinase that acts as a pivotal signaling effector downstream of Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs). Upon ligand engagement of these receptors, IRAK1 is recruited—often via the adaptor MyD88—to form a multiprotein “Myddosome” complex that facilitates its phosphorylation and subsequent activation of nuclear factor κB (NF-κB) and other transcription factors (such as IRF7) involved in innate and adaptive immune responses (8,9,4). In addition to its canonical role in propagating inflammatory signals in response to bacterial products, viral components, and even nonmicrobial stimuli such as saturated fatty acids, IRAK1 plays an indispensable role in the production of proinflammatory cytokines, including TNF-α, IL-6, and IL-8 (1,10)."}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Furthermore, IRAK1 function is tightly regulated at multiple levels. Posttranslational modifications—such as Lys63-linked ubiquitination—are critical for its ability to propagate downstream signaling events (13), while microRNA-mediated control, especially by miR-146a, serves as a negative feedback mechanism to dampen IRAK1 signaling and limit excessive inflammation (5,7,12). Such regulatory mechanisms are evident in diverse pathophysiological contexts: in plasmacytoid dendritic cells, IRAK1 is essential for TLR7- and TLR9-mediated induction of type I interferon responses (11), whereas in cancer, a gain-of-function mutation in the adaptor MYD88 promotes the spontaneous assembly of a signaling complex containing IRAK1 (and IRAK4) that sustains NF-κB activity and malignant cell survival (2). Likewise, endogenous inflammatory mediators such as Mrp8 can activate IRAK1 to promote cytokine secretion (3)."}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies underscore IRAK1’s central role as a signal transducer that integrates diverse receptor-mediated cues to orchestrate inflammatory responses, while its regulation by ubiquitination and microRNAs highlights its potential as a therapeutic target in inflammatory diseases, autoimmunity, and cancer.\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n "}, {"type": "b", "children": [{"type": "t", "text": "Citations:"}]}, {"type": "t", "text": "<br>\n (1)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "<br>\n (2)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "<br>\n (3)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "<br>\n (4)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "<br>\n (5)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "<br>\n (6)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "<br>\n (7)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "<br>\n (8)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "<br>\n (9)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "<br>\n (10)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "<br>\n (11)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "<br>\n (12)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "<br>\n (13)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Alexzander Asea, Michael Rehli, Edith Kabingu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M200497200"}], "href": "https://doi.org/10.1074/jbc.M200497200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11836257"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11836257"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Vu N Ngo, Ryan M Young, Roland Schmitz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oncogenically active MYD88 mutations in human lymphoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature09671"}], "href": "https://doi.org/10.1038/nature09671"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21179087"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21179087"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Thomas Vogl, Klaus Tenbrock, Stephan Ludwig, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm1638"}], "href": "https://doi.org/10.1038/nm1638"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17767165"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17767165"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Su-Chang Lin, Yu-Chih Lo, Hao Wu "}, {"type": "b", "children": [{"type": "t", "text": "Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature09121"}], "href": "https://doi.org/10.1038/nature09121"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20485341"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20485341"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Li-Fan Lu, Mark P Boldin, Ashutosh Chaudhry, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2010.08.012"}], "href": "https://doi.org/10.1016/j.cell.2010.08.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20850013"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20850013"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Krystian Jazdzewski, Elizabeth L Murray, Kaarle Franssila, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0802682105"}], "href": "https://doi.org/10.1073/pnas.0802682105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18474871"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18474871"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jin Hou, Pin Wang, Li Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-146a feedback inhibits RIG-I-dependent Type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.0900707"}], "href": "https://doi.org/10.4049/jimmunol.0900707"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19596990"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19596990"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Nobutaka Suzuki, Shinobu Suzuki, Gordon S Duncan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature736"}], "href": "https://doi.org/10.1038/nature736"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11923871"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11923871"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jae-Hyuck Shim, Changchun Xiao, Amber E Paschal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.1360605"}], "href": "https://doi.org/10.1101/gad.1360605"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16260493"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16260493"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Joo Y Lee, Jianping Ye, Zhanguo Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M305213200"}], "href": "https://doi.org/10.1074/jbc.M305213200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12865424"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12865424"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Satoshi Uematsu, Shintaro Sato, Masahiro Yamamoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20042372"}], "href": "https://doi.org/10.1084/jem.20042372"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15767370"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15767370"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Dipa Bhaumik, Gary K Scott, Shiruyeh Schokrpur, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.100042"}], "href": "https://doi.org/10.18632/aging.100042"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20148189"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20148189"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Christoph H Emmerich, Alban Ordureau, Sam Strickson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1314715110"}], "href": "https://doi.org/10.1073/pnas.1314715110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23986494"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23986494"}]}]}]}
Synonyms	IRAK, PELLE
Proteins	IRAK1_HUMAN
NCBI Gene ID	3654
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

IRAK1 has 13,146 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 142 datasets.

Click the + buttons to view associations for IRAK1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

IRAK1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of IRAK1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of IRAK1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of IRAK1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of IRAK1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of IRAK1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of IRAK1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving IRAK1 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of IRAK1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of IRAK1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of IRAK1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of IRAK1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of IRAK1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of IRAK1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with IRAK1 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with IRAK1 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of IRAK1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of IRAK1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of IRAK1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of IRAK1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of IRAK1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing IRAK1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing IRAK1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing IRAK1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with IRAK1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with IRAK1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing IRAK1 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of IRAK1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with IRAK1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with IRAK1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with IRAK1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of IRAK1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by IRAK1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DGIdb Drug Targets 2026	interacting drugs for IRAK1 protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving IRAK1 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving IRAK1 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with IRAK1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with IRAK1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with IRAK1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with IRAK1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with IRAK1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.