IRF2BP2 Gene

Name	interferon regulatory factor 2 binding protein 2
Description	This gene encodes an interferon regulatory factor-2 (IRF2) binding protein that interacts with the C-terminal transcriptional repression domain of IRF2. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Interferon regulatory factor 2 binding protein 2 (IRF2BP2) has emerged as a multifunctional transcriptional regulator whose activities are highly context dependent. Originally identified as a nuclear co‐repressor that interacts with IRF-2 via its zinc finger and RING finger domains to inhibit both enhancer‐activated and basal transcription independent of histone deacetylation (a)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", IRF2BP2 has been subsequently implicated in a variety of biological processes. In T lymphocytes, IRF2BP2 physiologically represses NFAT1‐dependent transactivation, thereby dampening cytokine production such as interleukin-2 and interleukin-4 (a)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", and its overexpression in CD4 T cells reduces activation markers and limits cell expansion (a)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In macrophages, IRF2BP2 is critically involved in maintaining an anti-inflammatory state by ensuring adequate expression of protective transcription factors like Krüppel-like factor 2 that, in turn, facilitate cholesterol efflux and suppress atherosclerotic inflammation (a)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the muscle and cardiac context, IRF2BP2 functions as a coactivator in partnership with other transcription factors. Its integration into the TEAD4/VGLL4 complex promotes the expression of vascular endothelial growth factor A (VEGFA), a key factor in angiogenesis and revascularization responses, with its nuclear localization being finely regulated by phosphorylation near a conserved nuclear localization signal (a)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "and."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Moreover, in septic cardiomyopathy models, cardiac overexpression of IRF2BP2 activates AMPK signaling, thereby protecting against myocardial inflammation and cell death (a)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In oncogenesis, IRF2BP2 appears to play dual and sometimes opposing roles. Chromosomal rearrangements involving IRF2BP2—such as fusions with NTRK1 in mesenchymal chondrosarcoma (a)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "and with other partners in thyroid carcinomas (a)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "—underscore its potential involvement in dysregulated transcriptional programs. In addition, copy number gains and overexpression of IRF2BP2 contribute to aggressive tumor biology in settings like triple-negative breast cancer (a)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "and gastric cancer (a)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ", where its aberrant activity associates with enhanced proliferation and poor clinical outcomes. Within the context of programmed cell death regulation, IRF2BP2 (also designated as DIF-1) is a critical component of a multi-protein repressor complex that modulates the expression of proapoptotic genes such as FASTKD2, thereby acting as a “death switch” in breast and prostate cancer cells (a)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Further adding to the versatility of its regulatory repertoire, post-translational modifications of IRF2BP2—such as transient deSUMOylation—are important for the timely expression of immediate early genes (a)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": " Beyond its roles in transcription and cell signaling, genetic mutations in IRF2BP2 have been implicated in familial immunodeficiency disorders (a)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": ", while naturally occurring genetic variation in its 3′-UTR has been linked to phenotypic traits in domestic sheep, such as wool fineness (a)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies highlight IRF2BP2 as a versatile transcriptional modulator whose activity is finely tuned by protein–protein interactions and post-translational modifications. Its ability to act either as a co-repressor or coactivator allows IRF2BP2 to impact key biological pathways—including immune regulation, cellular differentiation, angiogenesis, and tumorigenesis—thereby making it a compelling target for therapeutic intervention in a broad spectrum of diseases.\n "}]}, {"type": "t", "text": "\n \n <!--\n Citation numbering: \n (1) 12799427, (2) 21576369, (3) 27286791, (4) 26195219, (5) 20702774, (6) 21887377, (7) 32239393, (8) 28719467, (9) 32737449, (10) 32235890, (11) 31559693, (12) 21444724, (13) 25409762, (14) 33480129, (15) 27016798, (16) 34893856.\n -->"}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kay S Childs, Stephen Goodbourn "}, {"type": "b", "children": [{"type": "t", "text": "Identification of novel co-repressor molecules for Interferon Regulatory Factor-2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkg431"}], "href": "https://doi.org/10.1093/nar/gkg431"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12799427"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12799427"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Flávia R G Carneiro, Renata Ramalho-Oliveira, Giuliana P Mognol, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interferon regulatory factor 2 binding protein 2 is a new NFAT1 partner and represses its transcriptional activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00974-10"}], "href": "https://doi.org/10.1128/MCB.00974-10"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21576369"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21576369"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Cristiane Sécca, Douglas V Faget, Steffi C Hanschke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IRF2BP2 transcriptional repressor restrains naive CD4 T cell activation and clonal expansion induced by TCR triggering."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Leukoc Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1189/jlb.2A0815-368R"}], "href": "https://doi.org/10.1189/jlb.2A0815-368R"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27286791"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27286791"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hsiao-Huei Chen, Kianoosh Keyhanian, Xun Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IRF2BP2 Reduces Macrophage Inflammation and Susceptibility to Atherosclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.114.305777"}], "href": "https://doi.org/10.1161/CIRCRESAHA.114.305777"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26195219"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26195219"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Allen C T Teng, Drew Kuraitis, Shelley A Deeke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.10-167049"}], "href": "https://doi.org/10.1096/fj.10-167049"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20702774"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20702774"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Allen C T Teng, Naif A M Al-Montashiri, Brian L M Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a phosphorylation-dependent nuclear localization motif in interferon regulatory factor 2 binding protein 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0024100"}], "href": "https://doi.org/10.1371/journal.pone.0024100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21887377"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21887377"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Tianyu Li, Qiang Luo, Li He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interferon Regulatory Factor-2 Binding Protein 2 Ameliorates Sepsis-Induced Cardiomyopathy via AMPK-Mediated Anti-Inflammation and Anti-Apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Inflammation (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10753-020-01224-x"}], "href": "https://doi.org/10.1007/s10753-020-01224-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32239393"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32239393"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jaclyn F Hechtman, Ryma Benayed, David M Hyman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pan-Trk Immunohistochemistry Is an Efficient and Reliable Screen for the Detection of NTRK Fusions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Surg Pathol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/PAS.0000000000000911"}], "href": "https://doi.org/10.1097/PAS.0000000000000911"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28719467"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28719467"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Ying-Hsia Chu, Lori J Wirth, Alexander A Farahani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinicopathologic features of kinase fusion-related thyroid carcinomas: an integrative analysis with molecular characterization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mod Pathol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41379-020-0638-5"}], "href": "https://doi.org/10.1038/s41379-020-0638-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32737449"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32737449"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jichao He, Ronan P McLaughlin, Lambert van der Beek, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrative analysis of genomic amplification-dependent expression and loss-of-function screen identifies ASAP1 as a driver gene in triple-negative breast cancer progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-020-1279-3"}], "href": "https://doi.org/10.1038/s41388-020-1279-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32235890"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32235890"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yangyang Yao, Yi Wang, Li Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Down-regulation of interferon regulatory factor 2 binding protein 2 suppresses gastric cancer progression by negatively regulating connective tissue growth factor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.14677"}], "href": "https://doi.org/10.1111/jcmm.14677"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31559693"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31559693"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Kay T Yeung, Sharmistha Das, Jin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel transcription complex that selectively modulates apoptosis of breast cancer cells through regulation of FASTKD2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01381-10"}], "href": "https://doi.org/10.1128/MCB.01381-10"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21444724"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21444724"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Sharmistha Das, Kay T Yeung, Muktar A Mahajan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fas Activated Serine-Threonine Kinase Domains 2 (FASTKD2) mediates apoptosis of breast and prostate cancer cells through its novel FAST2 domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-14-852"}], "href": "https://doi.org/10.1186/1471-2407-14-852"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25409762"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25409762"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Sina V Barysch, Nicolas Stankovic-Valentin, Tim Miedema, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transient deSUMOylation of IRF2BP proteins controls early transcription in EGFR signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embr.201949651"}], "href": "https://doi.org/10.15252/embr.201949651"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33480129"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33480129"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Michael D Keller, Rahul Pandey, Dong Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutation in IRF2BP2 is responsible for a familial form of common variable immunodeficiency disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Allergy Clin Immunol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jaci.2016.01.018"}], "href": "https://doi.org/10.1016/j.jaci.2016.01.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27016798"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27016798"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Feng-Hua Lv, Yin-Hong Cao, Guang-Jian Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Whole-Genome Resequencing of Worldwide Wild and Domestic Sheep Elucidates Genetic Diversity, Introgression, and Agronomically Important Loci."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Evol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/molbev/msab353"}], "href": "https://doi.org/10.1093/molbev/msab353"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34893856"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34893856"}]}]}]}
Synonyms	CVID14
Proteins	I2BP2_HUMAN
NCBI Gene ID	359948
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

IRF2BP2 has 7,810 functional associations with biological entities spanning 8 categories (molecular profile, organism, disease, phenotype or trait, functional term, phrase or reference, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 111 datasets.

Click the + buttons to view associations for IRF2BP2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

IRF2BP2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by IRF2BP2 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of IRF2BP2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of IRF2BP2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of IRF2BP2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of IRF2BP2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of IRF2BP2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of IRF2BP2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of IRF2BP2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of IRF2BP2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of IRF2BP2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with IRF2BP2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with IRF2BP2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of IRF2BP2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of IRF2BP2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of IRF2BP2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with IRF2BP2 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing IRF2BP2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing IRF2BP2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing IRF2BP2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with IRF2BP2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of IRF2BP2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with IRF2BP2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with IRF2BP2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with IRF2BP2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of IRF2BP2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by IRF2BP2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with IRF2BP2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with IRF2BP2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with IRF2BP2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with IRF2BP2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with IRF2BP2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with IRF2BP2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at IRF2BP2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of IRF2BP2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of IRF2BP2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing IRF2BP2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD High Level Gene-Disease Associations	diseases associated with IRF2BP2 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with IRF2BP2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing IRF2BP2 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of IRF2BP2 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.