ITM2B Gene

HGNC Family	BRICHOS domain containing (BRICD)
Name	integral membrane protein 2B
Description	Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. [provided by RefSeq, Oct 2009]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nITM2B (also known as BRI2) is a type II transmembrane protein that undergoes multiple, highly regulated proteolytic processing steps. Initially, the immature protein is trafficked through the secretory pathway where it is N‐glycosylated and forms dimers—a process critical for its proper cell surface localization and subsequent proteolysis. Proteases such as furin and ADAM10 mediate ectodomain shedding, followed by intramembrane cleavage by SPPL2a/2b to yield distinct fragments including a soluble BRICHOS domain and intracellular peptides. These processing events suggest that ITM2B functions not only as a membrane‐bound protein but also as a source of bioactive fragments that can influence downstream signaling and cellular homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nA major function of ITM2B is its modulatory role in amyloid precursor protein (APP) metabolism. ITM2B interacts directly with mature APP at the plasma membrane and in endosomal compartments, thereby inhibiting its cleavage by α‐, β‐, and γ‐secretases. This negative regulation decreases the production of amyloidogenic peptides, such as Aβ and related toxic APP fragments. Moreover, the BRICHOS domain released from ITM2B exhibits chaperone‐like activity that efficiently prevents the fibrillization and aggregation of amyloidogenic peptides—not only Aβ linked to Alzheimer’s disease but also other aggregation‐prone proteins like IAPP. Thus, ITM2B acts as a critical endogenous inhibitor of amyloid formation, and its dysfunction—whether by mutation or loss of mature protein levels—has been implicated in familial British and Danish dementias as well as in Alzheimer’s disease pathogenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in amyloid regulation, ITM2B is important for neuronal function and synaptic integrity. Studies in knock‐in mouse models of familial British and Danish dementias demonstrate that mutations in ITM2B result in reduced levels of mature protein at synapses, culminating in impaired excitatory glutamatergic transmission and memory deficits. These synaptic alterations, which include diminished AMPA receptor–mediated responses and modified presynaptic release properties, underline a loss‐of-function mechanism that may contribute to neurodegenerative processes. Collectively, these findings place ITM2B at a central nexus linking proteolytic processing, regulation of APP metabolism, anti‐amyloid chaperoning, and the maintenance of normal synaptic communication."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "18", "end_ref": "20"}, {"type": "fg_f", "ref": "17"}, {"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Haruhiko Akiyama, Hiromi Kondo, Tetsuaki Arai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of BRI, the normal precursor of the amyloid protein of familial British dementia, in human brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Neuropathol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00401-003-0783-1"}], "href": "https://doi.org/10.1007/s00401-003-0783-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14586629"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14586629"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Seung-Il Choi, Ruben Vidal, Blas Frangione, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Axonal transport of British and Danish amyloid peptides via secretory vesicles."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.03-0730fje"}], "href": "https://doi.org/10.1096/fj.03-0730fje"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14656991"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14656991"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Lucas Martin, Regina Fluhrer, Karina Reiss, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M706661200"}], "href": "https://doi.org/10.1074/jbc.M706661200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17965014"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17965014"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Maria Tsachaki, Despina Serlidaki, Andriana Fetani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glycosylation of BRI2 on asparagine 170 is involved in its trafficking to the cell surface but not in its processing by furin or ADAM10."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Glycobiology (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/glycob/cwr097"}], "href": "https://doi.org/10.1093/glycob/cwr097"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21752865"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21752865"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Shuji Matsuda, Luca Giliberto, Yukiko Matsuda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.C500217200"}], "href": "https://doi.org/10.1074/jbc.C500217200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15983050"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15983050"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "A Rostagno, Y Tomidokoro, T Lashley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chromosome 13 dementias."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-005-5092-5"}], "href": "https://doi.org/10.1007/s00018-005-5092-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15968464"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15968464"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Angeliki Fotinopoulou, Maria Tsachaki, Maria Vlavaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.C500231200"}], "href": "https://doi.org/10.1074/jbc.C500231200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16027166"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16027166"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jungsu Kim, Victor M Miller, Yona Levites, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BRI2 (ITM2b) inhibits Abeta deposition in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.0891-08.2008"}], "href": "https://doi.org/10.1523/JNEUROSCI.0891-08.2008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18524908"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18524908"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Shuji Matsuda, Yukiko Matsuda, Luciano D'Adamio "}, {"type": "b", "children": [{"type": "t", "text": "BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.006403"}], "href": "https://doi.org/10.1074/jbc.M109.006403"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19366692"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19366692"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Shuji Matsuda, Yukiko Matsuda, Erik L Snapp, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Maturation of BRI2 generates a specific inhibitor that reduces APP processing at the plasma membrane and in endocytic vesicles."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurobiol Aging (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neurobiolaging.2009.08.005"}], "href": "https://doi.org/10.1016/j.neurobiolaging.2009.08.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19748705"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19748705"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Robert Tamayev, Luca Giliberto, Wei Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.3917-10.2010"}], "href": "https://doi.org/10.1523/JNEUROSCI.3917-10.2010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21048150"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21048150"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Robert Tamayev, Shuji Matsuda, Luca Giliberto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emboj.2011.161"}], "href": "https://doi.org/10.1038/emboj.2011.161"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21587206"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21587206"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Maria Tsachaki, Angeliki Fotinopoulou, Nefeli Slavi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BRI2 interacts with BACE1 and regulates its cellular levels by promoting its degradation and reducing its mRNA levels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Alzheimer Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2174/1567205011310050009"}], "href": "https://doi.org/10.2174/1567205011310050009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23701002"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23701002"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Stefan D Knight, Jenny Presto, Sara Linse, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The BRICHOS domain, amyloid fibril formation, and their relationship."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi400908x"}], "href": "https://doi.org/10.1021/bi400908x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24099305"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24099305"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Gefei Chen, Axel Abelein, Harriet E Nilsson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bri2 BRICHOS client specificity and chaperone activity are governed by assembly state."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-017-02056-4"}], "href": "https://doi.org/10.1038/s41467-017-02056-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29234026"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29234026"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Marie E Oskarsson, Erik Hermansson, Ye Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BRICHOS domain of Bri2 inhibits islet amyloid polypeptide (IAPP) fibril formation and toxicity in human beta cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1715951115"}], "href": "https://doi.org/10.1073/pnas.1715951115"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29507232"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29507232"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Marta Del Campo, Jeroen J M Hoozemans, Lois-Lee Dekkers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BRI2-BRICHOS is increased in human amyloid plaques in early stages of Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurobiol Aging (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neurobiolaging.2014.01.007"}], "href": "https://doi.org/10.1016/j.neurobiolaging.2014.01.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24524963"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24524963"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Maria Tsachaki, Jorge Ghiso, Agueda Rostagno, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BRI2 homodimerizes with the involvement of intermolecular disulfide bonds."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurobiol Aging (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neurobiolaging.2008.03.004"}], "href": "https://doi.org/10.1016/j.neurobiolaging.2008.03.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18440095"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18440095"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Wen Yao, Tao Yin, Marc D Tambini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Familial dementia gene ITM2b/BRI2 facilitates glutamate transmission via both presynaptic and postsynaptic mechanisms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-41340-9"}], "href": "https://doi.org/10.1038/s41598-019-41340-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30890756"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30890756"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Tao Yin, Wen Yao, Alexander D Lemenze, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Danish and British dementia ITM2b/BRI2 mutations reduce BRI2 protein stability and impair glutamatergic synaptic transmission."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA120.015679"}], "href": "https://doi.org/10.1074/jbc.RA120.015679"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33172889"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33172889"}]}]}]}
Synonyms	FBD, RDGCA, ABRI, BRI2, IMBRI2, BRICD2B, BRI, E3-16, E25B
Proteins	ITM2B_HUMAN
NCBI Gene ID	9445
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ITM2B has 8,376 functional associations with biological entities spanning 8 categories (molecular profile, organism, disease, phenotype or trait, functional term, phrase or reference, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 117 datasets.

Click the + buttons to view associations for ITM2B from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ITM2B Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ITM2B gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ITM2B gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ITM2B gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ITM2B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ITM2B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ITM2B gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ITM2B gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ITM2B gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ITM2B gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ITM2B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ITM2B gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with ITM2B protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ITM2B gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ITM2B gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ITM2B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ITM2B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with ITM2B gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with ITM2B gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing ITM2B protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ITM2B gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ITM2B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ITM2B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing ITM2B protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing ITM2B protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ITM2B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ITM2B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ITM2B gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ITM2B gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ITM2B gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ITM2B gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of ITM2B protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ITM2B gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving ITM2B gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving ITM2B gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ITM2B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ITM2B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ITM2B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ITM2B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ITM2B gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ITM2B gene from the ENCODE Transcription Factor Binding Site Profiles dataset.