ITPKB Gene

Name	inositol-trisphosphate 3-kinase B
Description	The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ITPKB is an inositol 1,4,5‐trisphosphate 3‐kinase that phosphorylates IP₃ to generate IP₄, thereby playing a pivotal role in modulating intracellular calcium signaling and a variety of downstream processes. In the nervous system, increased ITPKB expression has been implicated in Alzheimer’s disease, as its upregulation enhances ERK1/2 and β‐secretase activities, leading to tau hyperphosphorylation, amyloid‐β overproduction, and neuronal apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the immune compartment, ITPKB activity is essential for B cell survival and tolerance; by generating IP₄, it modulates Ras–Erk signaling through regulation of Rasa3 distribution and controls the expression of pro‐apoptotic Bim, thereby ensuring proper B cell function and preventing aberrant responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, ITPKB is critical in maintaining hematopoietic stem cell homeostasis; it limits cytokine‐induced PI3K/Akt/mTOR signaling to preserve HSC quiescence and long‐term repopulating capacity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Subcellular targeting studies further reveal that ITPKB contains a multitargeting domain that governs its nuclear export and association with cortical actin at the plasma membrane, suggesting a role in compartment‐specific calcium signal modulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In cancer cells, the product IP₄ contributes to redox homeostasis by competitively inhibiting NOX4 activity, reducing cisplatin‐induced reactive oxygen species and thereby promoting chemoresistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Finally, in the context of myelopoiesis, loss of ITPKB results in the hyperproliferation of granulocyte–monocyte progenitors and an attendant increase in neutrophil output, underscoring its role as a modulator of myeloid proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Evgenia Salta, Annerieke Sierksma, Elke Vanden Eynden, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Mol Med (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/emmm.201606520"}], "href": "https://doi.org/10.15252/emmm.201606520"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27485122"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27485122"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Virginie Stygelbout, Karelle Leroy, Valérie Pouillon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inositol trisphosphate 3-kinase B is increased in human Alzheimer brain and exacerbates mouse Alzheimer pathology."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/brain/awt344"}], "href": "https://doi.org/10.1093/brain/awt344"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24401760"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24401760"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yoann Maréchal, Xavier Pesesse, Yonghui Jia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inositol 1,3,4,5-tetrakisphosphate controls proapoptotic Bim gene expression and survival in B cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0704312104"}], "href": "https://doi.org/10.1073/pnas.0704312104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17709751"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17709751"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yoann Maréchal, Séverine Quéant, Selena Polizzi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inositol 1,4,5-trisphosphate 3-kinase B controls survival and prevents anergy in B cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunobiology (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.imbio.2010.03.012"}], "href": "https://doi.org/10.1016/j.imbio.2010.03.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20452702"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20452702"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Sabine Siegemund, Stephanie Rigaud, Claire Conche, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IP3 3-kinase B controls hematopoietic stem cell homeostasis and prevents lethal hematopoietic failure in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2014-06-583187"}], "href": "https://doi.org/10.1182/blood-2014-06-583187"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25788703"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25788703"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Marcus M Nalaskowski, Ralf Fliegert, Olga Ernst, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human inositol 1,4,5-trisphosphate 3-kinase isoform B (IP3KB) is a nucleocytoplasmic shuttling protein specifically enriched at cortical actin filaments and at invaginations of the nuclear envelope."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.173062"}], "href": "https://doi.org/10.1074/jbc.M110.173062"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21148483"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21148483"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Chaoyun Pan, Lingtao Jin, Xu Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inositol-triphosphate 3-kinase B confers cisplatin resistance by regulating NOX4-dependent redox balance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI124550"}], "href": "https://doi.org/10.1172/JCI124550"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31081803"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31081803"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yonghui Jia, Fabien Loison, Hidenori Hattori, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0800218105"}], "href": "https://doi.org/10.1073/pnas.0800218105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18339802"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18339802"}]}]}]}
Synonyms	IP3K, PIG37, IP3-3KB, IP3KB, IP3K-B
Proteins	IP3KB_HUMAN
NCBI Gene ID	3707
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ITPKB has 6,545 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 127 datasets.

Click the + buttons to view associations for ITPKB from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ITPKB Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ITPKB gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ITPKB gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ITPKB gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ITPKB gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ITPKB gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ITPKB gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ITPKB gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ITPKB gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ITPKB gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of ITPKB gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ITPKB gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ITPKB gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with ITPKB protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ITPKB gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ITPKB gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ITPKB gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ITPKB gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with ITPKB gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ITPKB gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ITPKB protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ITPKB protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ITPKB protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ITPKB protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ITPKB gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ITPKB gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ITPKB gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ITPKB gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of ITPKB protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ITPKB gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with ITPKB gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with ITPKB gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ITPKB gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ITPKB gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ITPKB gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ITPKB gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ITPKB gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ITPKB gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ITPKB gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ITPKB from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with ITPKB gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.