IVNS1ABP Gene

HGNC Family	Kelch-like (KLHL), BTB (POZ) domain containing (BTBD)
Name	influenza virus NS1A binding protein
Description	Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Involved in RNA splicing; negative regulation of protein ubiquitination; and response to virus. Located in cytosol. Implicated in immunodeficiency 70. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Influenza virus NS1‐binding protein (NS1‐BP) is a multifunctional host factor that interacts with the virus‐encoded non‐structural protein 1 (NS1) to regulate multiple steps of viral gene expression. NS1‐BP has been shown to promote the alternative splicing of the viral M1 mRNA, which is critical for the generation of the M2 ion channel mRNA necessary for proper viral trafficking, assembly, and budding."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, NS1‐BP functions in the nuclear export of processed viral mRNAs, thereby directly influencing influenza A virus replication dynamics."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n The expression level of NS1‐BP is subject to regulatory mechanisms involving host microRNAs, as exemplified by miRNA-548an, whose down-regulation during early infection drives increased accumulation of NS1‐BP; this up-regulation is associated with reduced apoptosis and enhanced viral maintenance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Moreover, structural studies reveal that NS1‐BP contains characteristic BTB, BACK, and Kelch domains, the latter of which adopts a six-bladed β-propeller fold essential for its splicing activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " These domains mediate dimerization and provide interfaces for interactions with several splicing factors – including hnRNP K and components of the spliceosome and mRNA export machinery – ultimately linking the processes of pre-mRNA splicing and nuclear export."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}, {"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " \n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its direct roles in viral mRNA processing, NS1‐BP participates in host cell signaling by forming complexes with adaptor proteins such as CRKL that modulate downstream pathways (e.g., ERK phosphorylation), thereby impacting cell survival during infection."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Collectively, these observations support a model in which NS1‐BP functions as a key regulatory hub that not only facilitates proper alternative splicing and export of a subset of viral mRNAs but also modulates host cell responses to create a cellular environment conducive to influenza virus replication.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Pei-Ling Tsai, Ni-Ting Chiou, Sharon Kuss, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cellular RNA binding proteins NS1-BP and hnRNP K regulate influenza A virus RNA splicing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Pathog (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.ppat.1003460"}], "href": "https://doi.org/10.1371/journal.ppat.1003460"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23825951"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23825951"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Matthew G Thompson, Raquel Muñoz-Moreno, Prasanna Bhat, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Co-regulatory activity of hnRNP K and NS1-BP in influenza and human mRNA splicing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-018-04779-4"}], "href": "https://doi.org/10.1038/s41467-018-04779-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29921878"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29921878"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ke Zhang, Guijun Shang, Abhilash Padavannil, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural-functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1818012115"}], "href": "https://doi.org/10.1073/pnas.1818012115"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30538201"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30538201"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Sreekumar Othumpangat, John D Noti, Francoise M Blachere, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of non-structural-1A binding protein in lung epithelial cells is modulated by miRNA-548an on exposure to influenza A virus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Virology (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.virol.2013.08.031"}], "href": "https://doi.org/10.1016/j.virol.2013.08.031"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24210102"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24210102"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Lu Guo, Yingfang Liu "}, {"type": "b", "children": [{"type": "t", "text": "Crystal structure of the Kelch domain of human NS1-binding protein at 1.98 Å resolution."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Crystallogr F Struct Biol Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1107/S2053230X18001577"}], "href": "https://doi.org/10.1107/S2053230X18001577"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29497022"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29497022"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "T Wolff, R E O'Neill, P Palese "}, {"type": "b", "children": [{"type": "t", "text": "NS1-Binding protein (NS1-BP): a novel human protein that interacts with the influenza A virus nonstructural NS1 protein is relocalized in the nuclei of infected cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (1998)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.72.9.7170-7180.1998"}], "href": "https://doi.org/10.1128/JVI.72.9.7170-7180.1998"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "9696811"}], "href": "https://pubmed.ncbi.nlm.nih.gov/9696811"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Masaya Miyazaki, Hiroshi Nishihara, Hideki Hasegawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NS1-binding protein abrogates the elevation of cell viability by the influenza A virus NS1 protein in association with CRKL."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2013.11.011"}], "href": "https://doi.org/10.1016/j.bbrc.2013.11.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24220336"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24220336"}]}]}]}
Synonyms	KLHL39, NS1BP, FLARA3, HSPC068, ARA3, NS-1, NS1-BP
Proteins	NS1BP_HUMAN
NCBI Gene ID	10625
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

IVNS1ABP has 8,182 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 118 datasets.

Click the + buttons to view associations for IVNS1ABP from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

IVNS1ABP Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by IVNS1ABP gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of IVNS1ABP gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of IVNS1ABP gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of IVNS1ABP gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of IVNS1ABP gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of IVNS1ABP gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of IVNS1ABP gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of IVNS1ABP gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of IVNS1ABP gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of IVNS1ABP gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of IVNS1ABP gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of IVNS1ABP gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of IVNS1ABP gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with IVNS1ABP protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with IVNS1ABP gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of IVNS1ABP gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of IVNS1ABP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of IVNS1ABP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with IVNS1ABP gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of IVNS1ABP gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing IVNS1ABP protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing IVNS1ABP protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing IVNS1ABP protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with IVNS1ABP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with IVNS1ABP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of IVNS1ABP gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with IVNS1ABP gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with IVNS1ABP gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with IVNS1ABP gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of IVNS1ABP protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by IVNS1ABP gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with IVNS1ABP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with IVNS1ABP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with IVNS1ABP gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with IVNS1ABP gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at IVNS1ABP gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of IVNS1ABP gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of IVNS1ABP gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing IVNS1ABP from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with IVNS1ABP gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.