| HGNC Family | IZUMO family (IZUMO) |
| Name | izumo sperm-egg fusion 1 |
| Description | The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma membrane binding and fusion (Inoue et al., 2005 [PubMed 15759005]).[supplied by OMIM, Mar 2008] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n IZUMO1 is a conserved, sperm‐specific membrane protein that plays an indispensable role in mammalian fertilization by mediating gamete adhesion and subsequent fusion. Its primary function is to establish a specific binding interaction with the egg membrane receptor JUNO, thereby initiating a cascade of events that ensure the merger of sperm and egg membranes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": " Structural studies have revealed that IZUMO1 exhibits an elongated, rod‐like shape comprised of a helical bundle and an immunoglobulin‐like domain, which together form a binding interface critical for interacting with JUNO. During the acrosome reaction, IZUMO1 dynamically redistributes from the acrosomal cap to the equatorial segment—the region where fusion is thought to initiate—and undergoes dimerization and higher order assembly; these modifications are essential for stabilizing the sperm–egg interface."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "10"}]}, {"type": "t", "text": " Although IZUMO1 itself does not possess intrinsic fusogenic activity, it functions as a central organizer within a multiprotein complex that includes other key factors (such as CD9 and SPACA6) to regulate membrane merging, and its activity is modulated by post‐translational modifications and protein–protein interactions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "15"}]}, {"type": "t", "text": " Collectively, insights into IZUMO1’s structure, dynamic membrane redistribution, and interactions have not only illuminated the mechanistic basis of sperm–egg recognition and fusion but have also provided promising avenues for the development of novel fertility treatments and non‐hormonal contraceptive approaches."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Enrica Bianchi, Brendan Doe, David Goulding, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Juno is the egg Izumo receptor and is essential for mammalian fertilization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature13203"}], "href": "https://doi.org/10.1038/nature13203"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24739963"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24739963"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Umeharu Ohto, Hanako Ishida, Elena Krayukhina, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature18596"}], "href": "https://doi.org/10.1038/nature18596"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27309808"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27309808"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Halil Aydin, Azmiri Sultana, Sheng Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular architecture of the human sperm IZUMO1 and egg JUNO fertilization complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature18595"}], "href": "https://doi.org/10.1038/nature18595"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27309818"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27309818"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Myriam Chalbi, Virginie Barraud-Lange, Benjamin Ravaux, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Binding of sperm protein Izumo1 and its egg receptor Juno drives Cd9 accumulation in the intercellular contact area prior to fusion during mammalian fertilization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.111534"}], "href": "https://doi.org/10.1242/dev.111534"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25209248"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25209248"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Kaoru Nishimura, Ling Han, Enrica Bianchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The structure of sperm Izumo1 reveals unexpected similarities with Plasmodium invasion proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cub.2016.06.028"}], "href": "https://doi.org/10.1016/j.cub.2016.06.028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27374339"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27374339"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yuhkoh Satouh, Naokazu Inoue, Masahito Ikawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Visualization of the moment of mouse sperm-egg fusion and dynamic localization of IZUMO1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.100867"}], "href": "https://doi.org/10.1242/jcs.100867"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22946049"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22946049"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Naokazu Inoue, Daizo Hamada, Hironari Kamikubo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular dissection of IZUMO1, a sperm protein essential for sperm-egg fusion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.094854"}], "href": "https://doi.org/10.1242/dev.094854"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23824580"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23824580"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Naokazu Inoue, Yoshihisa Hagihara, Danelle Wright, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oocyte-triggered dimerization of sperm IZUMO1 promotes sperm-egg fusion in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms9858"}], "href": "https://doi.org/10.1038/ncomms9858"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26568141"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26568141"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Naokazu Inoue, Ikuo Wada "}, {"type": "b", "children": [{"type": "t", "text": "Monitoring dimeric status of IZUMO1 during the acrosome reaction in living spermatozoon."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2018.1489181"}], "href": "https://doi.org/10.1080/15384101.2018.1489181"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29954238"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29954238"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Chong Zhou, Li Huang, De-Shun Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effects of latrunculin A on the relocation of sperm IZUMO1 during gamete interaction in mouse."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Reprod Dev (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mrd.22878"}], "href": "https://doi.org/10.1002/mrd.22878"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28833824"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28833824"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Diego A Ellerman, Jimin Pei, Surabhi Gupta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Reprod Dev (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mrd.21092"}], "href": "https://doi.org/10.1002/mrd.21092"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19658160"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19658160"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Samantha A M Young, Haruhiko Miyata, Yuhkoh Satouh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CRISPR/Cas9-mediated mutation revealed cytoplasmic tail is dispensable for IZUMO1 function and male fertility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reproduction (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1530/REP-16-0150"}], "href": "https://doi.org/10.1530/REP-16-0150"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27624483"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27624483"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Avinash S Gaikwad, Amanda L Anderson, D Jo Merriner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GLIPR1L1 is an IZUMO-binding protein required for optimal fertilization in the mouse."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12915-019-0701-1"}], "href": "https://doi.org/10.1186/s12915-019-0701-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31672133"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31672133"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Feng Xue, Li Wang, Yue Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vaccination with an Epitope Peptide of IZUMO1 to Induce Contraception in Female Mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Reprod Immunol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/aji.12485"}], "href": "https://doi.org/10.1111/aji.12485"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26782177"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26782177"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Tina O Findley, Joy C Tenpenny, Michelle R O'Byrne, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in folate transporter genes and risk for human myelomeningocele."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.38472"}], "href": "https://doi.org/10.1002/ajmg.a.38472"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28948692"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28948692"}]}]}]}
|
| Synonyms | OBF, IZUMO |
| Proteins | IZUM1_HUMAN |
| NCBI Gene ID | 284359 |
| API | |
| Download Associations | |
| Predicted Functions |
 |
| Co-expressed Genes |
|
| Expression in Tissues and Cell Lines |
|
IZUMO1 has 4,060 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 86 datasets.
Click the + buttons to view associations for IZUMO1 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of IZUMO1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of IZUMO1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of IZUMO1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of IZUMO1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of IZUMO1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of IZUMO1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of IZUMO1 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of IZUMO1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of IZUMO1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of IZUMO1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing IZUMO1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing IZUMO1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with IZUMO1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with IZUMO1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of IZUMO1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with IZUMO1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by IZUMO1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with IZUMO1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with IZUMO1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with IZUMO1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with IZUMO1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with IZUMO1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at IZUMO1 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of IZUMO1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of IZUMO1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing IZUMO1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GAD Gene-Disease Associations | diseases associated with IZUMO1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with IZUMO1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing IZUMO1 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of IZUMO1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of IZUMO1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of IZUMO1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of IZUMO1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of IZUMO1 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of IZUMO1 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving IZUMO1 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving IZUMO1 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving IZUMO1 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing IZUMO1 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing IZUMO1 protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing IZUMO1 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by IZUMO1 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by IZUMO1 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by IZUMO1 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx eQTL 2025 | SNPs regulating expression of IZUMO1 gene from the GTEx eQTL 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of IZUMO1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of IZUMO1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of IZUMO1 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| GWAS Catalog SNP-Phenotype Associations | phenotypes associated with IZUMO1 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with IZUMO1 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with IZUMO1 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with IZUMO1 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of IZUMO1 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of IZUMO1 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of IZUMO1 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of IZUMO1 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of IZUMO1 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with IZUMO1 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for IZUMO1 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of IZUMO1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of IZUMO1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of IZUMO1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of IZUMO1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with IZUMO1 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of IZUMO1 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain IZUMO1 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by IZUMO1 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of IZUMO1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by IZUMO1 gene mutations from the MPO Gene-Phenotype Associations dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of IZUMO1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of IZUMO1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| Reactome Pathways 2014 | pathways involving IZUMO1 protein from the Reactome Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving IZUMO1 protein from the Reactome Pathways 2024 dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of IZUMO1 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at IZUMO1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of IZUMO1 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of IZUMO1 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of IZUMO1 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of IZUMO1 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
| Tahoe Therapeutics Tahoe 100M Perturbation Atlas | drug perturbations changing expression of IZUMO1 gene from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of IZUMO1 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of IZUMO1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of IZUMO1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with IZUMO1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with IZUMO1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
| WikiPathways Pathways 2024 | pathways involving IZUMO1 protein from the WikiPathways Pathways 2024 dataset. | |
