JADE1 Gene

HGNC Family	Zinc fingers
Name	jade family PHD finger 1
Description	Enables transcription coactivator activity. Contributes to histone acetyltransferase activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; regulation of cell growth; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle. Located in several cellular components, including cytosol; microtubule organizing center; and nuclear speck. Part of histone acetyltransferase complex. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n JADE1 (also known as PHF17) is a multifunctional protein with key roles in chromatin regulation and tumor suppression. JADE1 operates in the nucleus as a transcriptional co‐activator that partners with the histone acetyltransferase HBO1 via its two conserved plant homeodomain (PHD) zinc fingers to promote histone H4 acetylation and hence modulate gene expression (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In renal epithelial cells, JADE1 is stabilized by the von Hippel‐Lindau tumor suppressor protein (pVHL), and its loss or destabilization is linked to enhanced tumor cell growth and reduced apoptosis; indeed, JADE1 downregulation correlates with renal tumorigenesis and poor clinical outcome (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In addition to modulating chromatin structure, JADE1 exerts E3 ubiquitin ligase activity toward key signaling proteins. For example, JADE1 binds and ubiquitylates β‐catenin in a manner that affects canonical Wnt signaling—a pathway critical for kidney development and tumor suppression—as well as regulating the abundance of pro‐apoptotic factors such as p21 (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Moreover, JADE1 interacts with components of cell cycle machinery; during mitosis the small JADE1 isoform (JADE1S) undergoes phosphorylation and shuttles between chromatin and the cytoplasm, localizing at centrosomes and later at the midbody during cytokinesis—a process that is sensitive to Aurora kinase activity, suggesting a role for JADE1 in regulating the cytokinetic checkpoint (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " JADE1 also contributes to the fine-tuning of proliferative signaling pathways; for example, it directly binds to AKT, thereby inhibiting AKT kinase activity, which further supports its tumor suppressor function in renal cells (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Finally, developmental studies and gene trap analyses have revealed that JADE1 expression in embryonic and progenitor cells may be compensated by related JADE family members, underscoring the importance of this family in the regulation of cell fate and organ homeostasis (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Maria V Panchenko, Mina I Zhou, Herbert T Cohen "}, {"type": "b", "children": [{"type": "t", "text": "von Hippel-Lindau partner Jade-1 is a transcriptional co-activator associated with histone acetyltransferase activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M410487200"}], "href": "https://doi.org/10.1074/jbc.M410487200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15502158"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15502158"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Rebecca L Foy, Ihn Young Song, Vipul C Chitalia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of Jade-1 in the histone acetyltransferase (HAT) HBO1 complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M801407200"}], "href": "https://doi.org/10.1074/jbc.M801407200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18684714"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18684714"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Mina I Zhou, Hongmei Wang, Jonathan J Ross, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M205040200"}], "href": "https://doi.org/10.1074/jbc.M205040200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12169691"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12169691"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Mina I Zhou, Rebecca L Foy, Vipul C Chitalia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Jade-1, a candidate renal tumor suppressor that promotes apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0500757102"}], "href": "https://doi.org/10.1073/pnas.0500757102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16046545"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16046545"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Vipul C Chitalia, Rebecca L Foy, Markus M Bachschmid, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1781"}], "href": "https://doi.org/10.1038/ncb1781"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18806787"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18806787"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Rebecca L Foy, Vipul C Chitalia, Maria V Panchenko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/dds391"}], "href": "https://doi.org/10.1093/hmg/dds391"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23001567"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23001567"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Nirodhini S Siriwardana, Rosana Meyer, Andrea Havasi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cell cycle-dependent chromatin shuttling of HBO1-JADE1 histone acetyl transferase (HAT) complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cc.28759"}], "href": "https://doi.org/10.4161/cc.28759"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24739512"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24739512"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Nirodhini S Siriwardana, Rosana D Meyer, Maria V Panchenko "}, {"type": "b", "children": [{"type": "t", "text": "The novel function of JADE1S in cytokinesis of epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2015.1068476"}], "href": "https://doi.org/10.1080/15384101.2015.1068476"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26151225"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26151225"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Liling Zeng, Ming Bai, Amit K Mittal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Candidate tumor suppressor and pVHL partner Jade-1 binds and inhibits AKT in renal cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-12-4707"}], "href": "https://doi.org/10.1158/0008-5472.CAN-12-4707"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23824745"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23824745"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Elena Tzouanacou, Susan Tweedie, Valerie Wilson "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.23.23.8553-8562.2003"}], "href": "https://doi.org/10.1128/MCB.23.23.8553-8562.2003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14612400"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14612400"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Maria V Panchenko "}, {"type": "b", "children": [{"type": "t", "text": "Structure, function and regulation of jade family PHD finger 1 (JADE1)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2016.05.002"}], "href": "https://doi.org/10.1016/j.gene.2016.05.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27155521"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27155521"}]}]}]}
Synonyms	PHF17
Proteins	JADE1_HUMAN
NCBI Gene ID	79960
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

JADE1 has 7,109 functional associations with biological entities spanning 8 categories (molecular profile, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 111 datasets.

Click the + buttons to view associations for JADE1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

JADE1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of JADE1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of JADE1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of JADE1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of JADE1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of JADE1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of JADE1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of JADE1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of JADE1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of JADE1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of JADE1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of JADE1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of JADE1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with JADE1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with JADE1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of JADE1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of JADE1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of JADE1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing JADE1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of JADE1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing JADE1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing JADE1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing JADE1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing JADE1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with JADE1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with JADE1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing JADE1 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with JADE1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with JADE1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of JADE1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by JADE1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with JADE1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with JADE1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with JADE1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with JADE1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at JADE1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of JADE1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of JADE1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing JADE1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of JADE1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with JADE1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.