JDP2 Gene

HGNC Family	Basic leucine zipper proteins
Name	Jun dimerization protein 2
Description	Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Part of RNA polymerase II transcription regulator complex. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Jun dimerization protein 2 (JDP2) is an AP‐1 family transcription factor with multifaceted roles in regulating gene expression, cellular differentiation, and proliferation through epigenetic mechanisms. Acting primarily as a transcriptional repressor, JDP2 recruits histone deacetylases to target gene promoters—such as that of c‐jun—to inhibit histone acetylation and thereby modulate differentiation programs in response to various stimuli."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n In mouse embryonic fibroblasts and other cell types, JDP2 limits cell cycle progression by binding to and repressing promoters (for instance, cyclin‐A2), thus acting as a brake on cell proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n Its activity is essential for proper cell fate decisions; for example, JDP2 enhances somatic cell reprogramming by replacing classical pluripotency factors and anchoring non‐Yamanaka factors to drive induced pluripotency"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", while in other contexts it promotes skeletal muscle differentiation through cell cycle arrest and activation of myogenic programs.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n JDP2 also plays critical roles in differentiation processes in vivo. It is required for proper osteoclastogenesis and neutrophil maturation, with knockout models exhibiting osteopetrosis and impaired immune cell functions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In adipocyte differentiation, JDP2 represses the expression of key transcription factors such as C/EBPδ by inhibiting local histone acetylation, thereby limiting adipogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to modulating differentiation and proliferation, JDP2 is intimately involved in cellular responses to stress. It acts as a cofactor for the Nrf2–MafK complex to enhance antioxidant response element–driven transcription and protect cells against oxidative stress and reactive oxygen species accumulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Moreover, by associating directly with several histone deacetylases via its bZIP domain, JDP2 contributes to the repression of its own and other promoters, thereby fine‐tuning stress and oncogenic responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Functionally, JDP2 displays context‐dependent roles in tumorigenesis. Its ability to generate inhibitory AP‐1 complexes contributes to tumor suppression in certain cellular models"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ", yet, in other settings—such as during the promotion stage of liver cancer—JDP2 overexpression may potentiate oncogenic processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Additionally, JDP2 is integrated within broader regulatory networks, including those governed by stem cell factors like Nanog, influencing pathways such as the p53 and cell cycle circuits."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies illustrate that JDP2 is a versatile modulator of transcription whose repressive and context‐dependent activities are critical for balancing cellular proliferation, differentiation, and stress responses.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jing Liu, Qingkai Han, Tianran Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The oncogene c-Jun impedes somatic cell reprogramming."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb3193"}], "href": "https://doi.org/10.1038/ncb3193"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26098572"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26098572"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chunyuan Jin, Hongjie Li, Takehide Murata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "JDP2, a repressor of AP-1, recruits a histone deacetylase 3 complex to inhibit the retinoic acid-induced differentiation of F9 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.22.13.4815-4826.2002"}], "href": "https://doi.org/10.1128/MCB.22.13.4815-4826.2002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12052888"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12052888"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "J Pan, K Nakade, Y-C Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Suppression of cell-cycle progression by Jun dimerization protein-2 (JDP2) involves downregulation of cyclin-A2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2010.355"}], "href": "https://doi.org/10.1038/onc.2010.355"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20802531"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20802531"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Kenta Maruyama, Masahiro Fukasaka, Alexis Vandenbon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The transcription factor Jdp2 controls bone homeostasis and antibacterial immunity by regulating osteoclast and neutrophil differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2012.08.022"}], "href": "https://doi.org/10.1016/j.immuni.2012.08.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23200825"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23200825"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "K Nakade, J Pan, A Yoshiki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "JDP2 suppresses adipocyte differentiation by regulating histone acetylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.cdd.4402129"}], "href": "https://doi.org/10.1038/sj.cdd.4402129"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17464331"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17464331"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "S Tanigawa, C H Lee, C S Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Jun dimerization protein 2 is a critical component of the Nrf2/MafK complex regulating the response to ROS homeostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2013.448"}], "href": "https://doi.org/10.1038/cddis.2013.448"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24232097"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24232097"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Ilona Darlyuk-Saadon, Keren Weidenfeld-Baranboim, Kazunari K Yokoyama, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The bZIP repressor proteins, c-Jun dimerization protein 2 and activating transcription factor 3, recruit multiple HDAC members to the ATF3 promoter."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbagrm.2012.09.005"}], "href": "https://doi.org/10.1016/j.bbagrm.2012.09.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22989952"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22989952"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Ronit Heinrich, Erella Livne, Offer Ben-Izhak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The c-Jun dimerization protein 2 inhibits cell transformation and acts as a tumor suppressor gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M307608200"}], "href": "https://doi.org/10.1074/jbc.M307608200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14627710"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14627710"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Keren Bitton-Worms, Eli Pikarsky, Ami Aronheim "}, {"type": "b", "children": [{"type": "t", "text": "The AP-1 repressor protein, JDP2, potentiates hepatocellular carcinoma in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1476-4598-9-54"}], "href": "https://doi.org/10.1186/1476-4598-9-54"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20214788"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20214788"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Seung-Cheol Choi, Ji-Hyun Choi, Chi-Yeon Park, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nanog regulates molecules involved in stemness and cell cycle-signaling pathway for maintenance of pluripotency of P19 embryonal carcinoma stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.24076"}], "href": "https://doi.org/10.1002/jcp.24076"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22378194"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22378194"}]}]}]}
Synonyms	JUNDM2
Proteins	JDP2_HUMAN
NCBI Gene ID	122953
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

JDP2 has 5,975 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 114 datasets.

Click the + buttons to view associations for JDP2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

JDP2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by JDP2 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of JDP2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of JDP2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of JDP2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of JDP2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of JDP2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of JDP2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of JDP2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of JDP2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of JDP2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of JDP2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with JDP2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with JDP2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of JDP2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of JDP2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of JDP2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing JDP2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing JDP2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing JDP2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with JDP2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with JDP2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of JDP2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with JDP2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with JDP2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with JDP2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of JDP2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by JDP2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with JDP2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with JDP2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with JDP2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with JDP2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with JDP2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for JDP2 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at JDP2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of JDP2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of JDP2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing JDP2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with JDP2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with JDP2 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with JDP2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.