JMY Gene

HGNC Family	Wiskott-Aldrich Syndrome protein family
Name	junction mediating and regulatory protein, p53 cofactor
Description	Enables microtubule binding activity. Involved in cellular response to starvation. Located in autophagosome membrane; cell leading edge; and cytoplasmic vesicle. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Junction-mediating and regulatory protein (JMY) is a multifunctional protein that integrates transcriptional regulation with cytoskeletal dynamics. Initially identified as a p53 transcriptional co‐activator, JMY directly promotes p53‐dependent gene expression and apoptosis following DNA damage, a function that is controlled in part by its regulated nuclear import and degradation by Mdm2."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the cytoplasm, JMY functions as an actin nucleation factor. It uniquely combines two nucleation mechanisms by both activating the Arp2/3 complex and assembling actin filaments directly through a mechanism reminiscent of Spire."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Its C‐terminal WH2 domains not only drive actin assembly but also overlap with a nuclear localization signal, enabling the dynamic regulation of its subcellular distribution; binding of actin monomers to these domains prevents nuclear import, thereby coupling the protein’s localization to the state of actin polymerization."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Furthermore, JMY promotes cell migration and vesicular trafficking by generating actin networks that support membrane remodeling. In mouse oocytes, proper levels of JMY are required for spindle migration and the establishment of polarity during asymmetric division."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Under hypoxic conditions, HIF-1α upregulates JMY to enhance cell motility and invasion, suggesting a role in stress-adaptive cellular remodeling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Finally, similarities in localization with other nucleation-promoting factors involved in autophagy hint at additional roles of JMY in regulating autophagosome biogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "J Bradley Zuchero, Amanda S Coutts, Margot E Quinlan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p53-cofactor JMY is a multifunctional actin nucleation factor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1852"}], "href": "https://doi.org/10.1038/ncb1852"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19287377"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19287377"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Amanda S Coutts, Houda Boulahbel, Anne Graham, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mdm2 targets the p53 transcription cofactor JMY for degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.embor.7400855"}], "href": "https://doi.org/10.1038/sj.embor.7400855"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17170761"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17170761"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Amanda S Coutts, Nicholas B La Thangue "}, {"type": "b", "children": [{"type": "t", "text": "Actin nucleation by WH2 domains at the autophagosome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms8888"}], "href": "https://doi.org/10.1038/ncomms8888"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26223951"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26223951"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "J Bradley Zuchero, Brittany Belin, R Dyche Mullins "}, {"type": "b", "children": [{"type": "t", "text": "Actin binding to WH2 domains regulates nuclear import of the multifunctional actin regulator JMY."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E11-12-0992"}], "href": "https://doi.org/10.1091/mbc.E11-12-0992"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22262458"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22262458"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xiaohua Hu, R Dyche Mullins "}, {"type": "b", "children": [{"type": "t", "text": "LC3 and STRAP regulate actin filament assembly by JMY during autophagosome formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201802157"}], "href": "https://doi.org/10.1083/jcb.201802157"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30420355"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30420355"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Shao-Chen Sun, Qing-Yuan Sun, Nam-Hyung Kim "}, {"type": "b", "children": [{"type": "t", "text": "JMY is required for asymmetric division and cytokinesis in mouse oocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Hum Reprod (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/molehr/gar006"}], "href": "https://doi.org/10.1093/molehr/gar006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21266449"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21266449"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Amanda S Coutts, Louise Weston, Nicholas B La Thangue "}, {"type": "b", "children": [{"type": "t", "text": "A transcription co-factor integrates cell adhesion and motility with the p53 response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0906785106"}], "href": "https://doi.org/10.1073/pnas.0906785106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19897726"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19897726"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "A S Coutts, I M Pires, L Weston, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypoxia-driven cell motility reflects the interplay between JMY and HIF-1α."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2011.188"}], "href": "https://doi.org/10.1038/onc.2011.188"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21625218"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21625218"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "David J Kast, Allison L Zajac, Erika L F Holzbaur, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WHAMM Directs the Arp2/3 Complex to the ER for Autophagosome Biogenesis through an Actin Comet Tail Mechanism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cub.2015.05.042"}], "href": "https://doi.org/10.1016/j.cub.2015.05.042"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26096974"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26096974"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Kai Schlüter, Dieter Waschbüsch, Moritz Anft, et al. "}, {"type": "b", "children": [{"type": "t", "text": "JMY is involved in anterograde vesicle trafficking from the trans-Golgi network."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Cell Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejcb.2014.06.001"}], "href": "https://doi.org/10.1016/j.ejcb.2014.06.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25015719"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25015719"}]}]}]}
Synonyms	WHAMM2, WHDC1L3
Proteins	JMY_HUMAN
NCBI Gene ID	133746
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

JMY has 5,734 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 107 datasets.

Click the + buttons to view associations for JMY from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

JMY Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of JMY gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of JMY gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of JMY gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of JMY gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of JMY gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of JMY gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of JMY gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of JMY gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of JMY gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of JMY gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with JMY protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with JMY gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of JMY gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of JMY gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of JMY gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing JMY protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing JMY protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing JMY protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with JMY protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with JMY protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of JMY gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with JMY gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with JMY gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with JMY gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of JMY protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by JMY gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with JMY gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with JMY gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with JMY gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with JMY gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at JMY gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of JMY gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of JMY gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing JMY from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with JMY gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with JMY gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with JMY gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing JMY from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of JMY gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of JMY gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.