{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have revealed multifaceted roles for KAT14‐related factors in the regulation of chromatin structure, development, and cancer. On one hand, KAT14 has been identified as a subunit of the human ATAC (hATAC) histone acetyltransferase complex, where it is directly bound by nuclear actin. This interaction modulates KAT14’s acetyltransferase activity, thereby influencing histone acetylation and chromatin organization, which are critical for proper gene expression and genomic integrity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In insect models such as the pea aphid (Acyrthosiphon pisum), RNA interference targeting several histone acetyltransferase genes—including kat14—has demonstrated that suppression of kat14 can result in improved survival and an increased number of offspring. These findings indicate that KAT14 plays an important role in developmental and life‐history regulation by potentially restricting certain aspects of reproduction."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, in the context of tongue squamous cell carcinoma, a long noncoding RNA termed lncRNA‑KAT14 has been implicated as a negative regulator of tumor progression. Upregulation of lncRNA‑KAT14—observed upon treatment with the γ‑secretase inhibitor DAPT—correlates with decreased cell proliferation, migration, invasion, and epithelial–mesenchymal transition. Conversely, knockdown of lncRNA‑KAT14 enhances these malignant properties, suggesting that lncRNA‑KAT14 exerts a tumor suppressive role through its impact on oncogenic signaling pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these data underscore that KAT14, whether functioning as a chromatin modifier within the hATAC complex, as a regulatory gene affecting developmental outcomes in invertebrates, or as part of a long noncoding RNA network in cancer cells, plays a critical role in epigenetic regulation. Its activity appears to balance chromatin acetylation–dependent gene expression programs that are vital for proper cellular function, organismal development, and the suppression of tumor progression.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tiina Viita, Salla Kyheröinen, Bina Prajapati, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.226852"}], "href": "https://doi.org/10.1242/jcs.226852"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30890647"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30890647"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Phillipp Kirfel, Marisa Skaljac, Jens Grotmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of histone acetylation and deacetylation enzymes affects longevity, development, and fecundity in the pea aphid (Acyrthosiphon pisum)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Insect Biochem Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/arch.21614"}], "href": "https://doi.org/10.1002/arch.21614"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31498475"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31498475"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "F Liu, H-X Chu, J-S Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibitory effect of the Notch pathway-inhibitor DAPT on invasion and metastasis of tongue cancer via lncRNA-KAT14 regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202001_19911"}], "href": "https://doi.org/10.26355/eurrev_202001_19911"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31957832"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31957832"}]}]}]}