KAT5 Gene

HGNC Family	Chromatin-modifying enzymes, Zinc fingers
Name	K(lysine) acetyltransferase 5
Description	The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n KAT5, also known as TIP60, is a versatile MYST‐family histone acetyltransferase that functions as a central epigenetic integrator in numerous cellular processes. It plays a critical role in the DNA damage response by acetylating key substrates—including histones such as H2AX and the protein kinase ATM—to promote chromatin remodeling, facilitate the recruitment of repair factors, and activate checkpoint signaling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n Furthermore, TIP60 acetylates the tumor suppressor p53 on lysine 120, a modification that is crucial for selectively triggering apoptotic pathways over cell‐cycle arrest in response to genotoxic stress."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n As an essential component of the NuA4 complex, TIP60 drives transcriptional activation by acetylating nucleosomal histones to create an open chromatin state that permits recruitment of transcriptional machinery at promoters and enhancers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " In addition, TIP60 modulates oncogenic and developmental pathways through direct acetylation of transcription factors such as c-MYC, Twist, and the androgen receptor, thereby enhancing their stability, altering their chromatin binding, or facilitating coactivator recruitment."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "12"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its actions on histones and transcription factors, TIP60 also acetylates non-histone proteins such as DNMT1, thereby targeting them for ubiquitin-mediated degradation and linking acetylation to regulation of protein stability."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": " Moreover, by serving as a conduit between kinase signaling and autophagy regulators, TIP60 is implicated in modulating autophagy in response to growth factor deprivation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these functions underscore KAT5/TIP60’s pivotal role in safeguarding genomic integrity by coordinating DNA repair, regulating gene transcription, and modulating protein stability. Its multi-faceted activities also contribute to tumor suppression, particularly in early oncogenic stress, highlighting its significance in both normal physiology and disease contexts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yingli Sun, Xiaofeng Jiang, Shujuan Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0504211102"}], "href": "https://doi.org/10.1073/pnas.0504211102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16141325"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16141325"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yingli Sun, Xiaofeng Jiang, Ye Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1982"}], "href": "https://doi.org/10.1038/ncb1982"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19783983"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19783983"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yingli Sun, Ye Xu, Kanaklata Roy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01382-07"}], "href": "https://doi.org/10.1128/MCB.01382-07"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17923702"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17923702"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jiangbo Tang, Nam Woo Cho, Gaofeng Cui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsmb.2499"}], "href": "https://doi.org/10.1038/nsmb.2499"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23377543"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23377543"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Stephen M Sykes, Hestia S Mellert, Marc A Holbert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Acetylation of the p53 DNA-binding domain regulates apoptosis induction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2006.11.026"}], "href": "https://doi.org/10.1016/j.molcel.2006.11.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17189187"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17189187"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yi Tang, Jianyuan Luo, Wenzhu Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2006.11.021"}], "href": "https://doi.org/10.1016/j.molcel.2006.11.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17189186"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17189186"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yannick Doyon, William Selleck, William S Lane, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.24.5.1884-1896.2004"}], "href": "https://doi.org/10.1128/MCB.24.5.1884-1896.2004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14966270"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14966270"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Rabih Murr, Joanna I Loizou, Yun-Gui Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1343"}], "href": "https://doi.org/10.1038/ncb1343"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16341205"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16341205"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jagruti H Patel, Yanping Du, Penny G Ard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.24.24.10826-10834.2004"}], "href": "https://doi.org/10.1128/MCB.24.24.10826-10834.2004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15572685"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15572685"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jian Shi, Yifan Wang, Lei Zeng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccr.2014.01.028"}], "href": "https://doi.org/10.1016/j.ccr.2014.01.028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24525235"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24525235"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Luke Gaughan, Ian R Logan, Susan Cook, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M203423200"}], "href": "https://doi.org/10.1074/jbc.M203423200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11994312"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11994312"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Xinwei Cao, Thomas C Südhof "}, {"type": "b", "children": [{"type": "t", "text": "Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M402248200"}], "href": "https://doi.org/10.1074/jbc.M402248200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15044485"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15044485"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Zhanwen Du, Jing Song, Yong Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.2001462"}], "href": "https://doi.org/10.1126/scisignal.2001462"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21045206"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21045206"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Shu-Yong Lin, Terytty Yang Li, Qing Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1217032"}], "href": "https://doi.org/10.1126/science.1217032"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22539723"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22539723"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Chiara Gorrini, Massimo Squatrito, Chiara Luise, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature06055"}], "href": "https://doi.org/10.1038/nature06055"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17728759"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17728759"}]}]}]}
Synonyms	CPLA2, HTATIP1, PLIP, HTATIP, TIP60
Proteins	KAT5_HUMAN
NCBI Gene ID	10524
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

KAT5 has 9,015 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 130 datasets.

Click the + buttons to view associations for KAT5 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

KAT5 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by KAT5 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KAT5 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of KAT5 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of KAT5 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of KAT5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of KAT5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KAT5 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving KAT5 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of KAT5 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of KAT5 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of KAT5 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of KAT5 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with KAT5 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with KAT5 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of KAT5 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of KAT5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of KAT5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with KAT5 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing KAT5 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of KAT5 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing KAT5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing KAT5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing KAT5 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with KAT5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with KAT5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing KAT5 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of KAT5 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with KAT5 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with KAT5 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with KAT5 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of KAT5 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with KAT5 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with KAT5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with KAT5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with KAT5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with KAT5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for KAT5 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at KAT5 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of KAT5 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of KAT5 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.