KCNAB2 Gene

HGNC Family	Aldo-keto reductases (AKR), Potassium channel, voltage gated regulatory beta subunits
Name	potassium channel, voltage gated subfamily A regulatory beta subunit 2
Description	Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n KCNAB2 encodes the auxiliary β subunit (Kvβ2) of voltage‐gated potassium channels, a key modulatory component that regulates channel function by modifying gating kinetics, trafficking, and current amplitude. In cardiac tissue, Kvβ2 can associate with channels such as Kv1.5 to increase potassium currents and alter atrial-specific repolarization, with genetic variants linked to both gain‐ and loss‐of‐function effects that predispose to atrial fibrillation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the brain, deletion of KCNAB2 has been shown to reduce the slow afterhyperpolarization following bursts of action potentials, thereby increasing neuronal excitability and contributing to deficits in associative learning and memory, a finding that may explain some of the cognitive impairments seen in 1p36 deletion syndrome."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, altered methylation and expression of KCNAB2 in pituitary tumors have been associated with changes in growth hormone secretion, underscoring its role in endocrine regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In addition, Kvβ2 interacts with key proteins in the neuronal signaling network—for instance, binding to the long non‐coding RNA NEAT1 has been implicated in modulating excitability in the context of epileptic phenotypes"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "and its association with the TRPV1 channel enhances receptor surface expression and ligand sensitivity, potentially affecting nociception."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Furthermore, studies in non‐mammalian species such as cartilaginous fish reveal that the conserved KCNAB2 ortholog is an integral component of the channel complex in specialized electroreceptors, reinforcing its fundamental role in modulating voltage‐dependent potassium currents across species."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Finally, gene co-expression analyses in human brain have identified KCNAB2 as a hub gene in synaptic transmission networks, highlighting its multifaceted contribution to maintaining neuronal excitability and synaptic integrity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ingrid E Christophersen, Morten S Olesen, Bo Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variation in KCNA5: impact on the atrial-specific potassium current IKur in patients with lone atrial fibrillation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Heart J (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/eurheartj/ehs442"}], "href": "https://doi.org/10.1093/eurheartj/ehs442"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23264583"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23264583"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "John J Perkowski, Geoffrey G Murphy "}, {"type": "b", "children": [{"type": "t", "text": "Deletion of the mouse homolog of KCNAB2, a gene linked to monosomy 1p36, results in associative memory impairments and amygdala hyperexcitability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.2634-10.2011"}], "href": "https://doi.org/10.1523/JNEUROSCI.2634-10.2011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21209188"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21209188"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Charles Ashton, Suhn K Rhie, John D Carmichael, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of KCNAB2 expression in modulating hormone secretion in somatotroph pituitary adenoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosurg (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3171/2019.12.JNS192435"}], "href": "https://doi.org/10.3171/2019.12.JNS192435"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32109873"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32109873"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Guy Barry, James A Briggs, Do Won Hwang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The long non-coding RNA NEAT1 is responsive to neuronal activity and is associated with hyperexcitability states."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep40127"}], "href": "https://doi.org/10.1038/srep40127"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28054653"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28054653"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Carlo Bavassano, Letizia Marvaldi, Michiel Langeslag, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of voltage-gated K(+) channel beta 2 (Kvβ2) subunit as a novel interaction partner of the pain transducer Transient Receptor Potential Vanilloid 1 channel (TRPV1)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2013.09.001"}], "href": "https://doi.org/10.1016/j.bbamcr.2013.09.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24036102"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24036102"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "William T Clusin, Ting-Hsuan Wu, Ling-Fang Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Further studies of ion channels in the electroreceptor of the skate through deep sequencing, cloning and cross species comparisons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2019.143989"}], "href": "https://doi.org/10.1016/j.gene.2019.143989"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31326551"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31326551"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Julio Rodriguez-López, Manuel Arrojo, Eduardo Paz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of relevant hub genes for early intervention at gene coexpression modules with altered predicted expression in schizophrenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Prog Neuropsychopharmacol Biol Psychiatry (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.pnpbp.2019.109815"}], "href": "https://doi.org/10.1016/j.pnpbp.2019.109815"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31715283"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31715283"}]}]}]}
Synonyms	KCNA2B, HKVBETA2, KV-BETA-2, AKR6A5, HKVBETA2.2, HKVBETA2.1
Proteins	KCAB2_HUMAN
NCBI Gene ID	8514
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

KCNAB2 has 7,239 functional associations with biological entities spanning 9 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 124 datasets.

Click the + buttons to view associations for KCNAB2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

KCNAB2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KCNAB2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of KCNAB2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of KCNAB2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of KCNAB2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KCNAB2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of KCNAB2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of KCNAB2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of KCNAB2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of KCNAB2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of KCNAB2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with KCNAB2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with KCNAB2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of KCNAB2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of KCNAB2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of KCNAB2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with KCNAB2 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of KCNAB2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing KCNAB2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing KCNAB2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with KCNAB2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with KCNAB2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of KCNAB2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with KCNAB2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with KCNAB2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with KCNAB2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of KCNAB2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by KCNAB2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving KCNAB2 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with KCNAB2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with KCNAB2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with KCNAB2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with KCNAB2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with KCNAB2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at KCNAB2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of KCNAB2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of KCNAB2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing KCNAB2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of KCNAB2 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with KCNAB2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing KCNAB2 from the GeneSigDB Published Gene Signatures dataset.