KCNE2 Gene

HGNC Family	Potassium channel, voltage gated regulatory beta subunits
Name	potassium channel, voltage gated subfamily E regulatory beta subunit 2
Description	Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n KCNE2 is a multifunctional β‐subunit that modulates the function of several cardiac and non‐cardiac ion channels, thereby influencing both electrical activity and cellular physiology. In the heart, KCNE2 co‐assembles with different pore‐forming α‐subunits to fine‐tune channel properties. When associated with KCNQ1, KCNE2 can alter the amplitude and kinetics of the slowly activating delayed rectifier current (I<sub>Ks</sub>), with specific mutations (for example, the R27C variant) producing a gain‐of‐function effect that is linked to atrial fibrillation (AF) susceptibility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, KCNE2 is known to interact with HERG channels that carry I<sub>Kr</sub> and with HCN4 channels that underlie pacemaker (I<sub>f</sub> or I<sub>h</sub>) currents. The modulation of HCN4 by KCNE2 results in enhanced current amplitudes, slower activation kinetics, and a hyperpolarized shift in voltage dependence, thereby contributing to the diversity of pacemaking currents."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In ventricular myocytes, studies in murine models demonstrate that disruption of KCNE2 leads to decreased levels of mature Kv channel proteins (such as Kv1.5) and altered current properties that prolong action potential duration and the QT interval, thus potentially increasing arrhythmic risk."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Moreover, KCNE2’s influence on KCNQ1 is context dependent; in one case, a KCNQ1 mutation when co‐expressed with KCNE2 produced a gain‐of‐function in the atria yet a loss‐of‐function in the ventricles, underscoring the importance of the subunit’s modulatory role in determining regional electrophysiological behavior."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Beyond its cardiac roles, KCNE2 is critically involved in gastrointestinal physiology. In gastric parietal cells, KCNE2 forms a native channel complex with KCNQ1 that is essential for proton secretion. Disruption of KCNE2 in mice provokes severe hypochlorhydria, hypergastrinemia, and marked gastric gland hyperplasia, thereby establishing its indispensable role in normal gastric acid secretion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, KCNE2 serves as a versatile modulator of ion channel complexes. Its regulation of channel gating, current density, and protein trafficking across distinct tissues is a key determinant of cardiac excitability and gastrointestinal function. Alterations in KCNE2 function—via genetic mutations or changes in expression—can predispose to arrhythmias such as atrial fibrillation and long‐QT syndrome, as well as impair gastric acid secretion. These findings emphasize the importance of KCNE2 in both cardiac electrophysiology and digestive homeostasis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yi-Han Chen, Shi-Jie Xu, Said Bendahhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "KCNQ1 gain-of-function mutation in familial atrial fibrillation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1077771"}], "href": "https://doi.org/10.1126/science.1077771"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12522251"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12522251"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yiqing Yang, Min Xia, Qingfeng Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a KCNE2 gain-of-function mutation in patients with familial atrial fibrillation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1086/425342"}], "href": "https://doi.org/10.1086/425342"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15368194"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15368194"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Niels Decher, Florian Bundis, Rolf Vajna, et al. "}, {"type": "b", "children": [{"type": "t", "text": "KCNE2 modulates current amplitudes and activation kinetics of HCN4: influence of KCNE family members on HCN4 currents."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pflugers Arch (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00424-003-1127-7"}], "href": "https://doi.org/10.1007/s00424-003-1127-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12856183"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12856183"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Torsten K Roepke, Arun Anantharam, Philipp Kirchhoff, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The KCNE2 potassium channel ancillary subunit is essential for gastric acid secretion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M604155200"}], "href": "https://doi.org/10.1074/jbc.M604155200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16754665"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16754665"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Torsten K Roepke, Andrianos Kontogeorgis, Christopher Ovanez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeted deletion of kcne2 impairs ventricular repolarization via disruption of I(K,slow1) and I(to,f)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.08-110171"}], "href": "https://doi.org/10.1096/fj.08-110171"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18603586"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18603586"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Alicia Lundby, Lasse Steen Ravn, Jesper Hastrup Svendsen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "KCNQ1 mutation Q147R is associated with atrial fibrillation and prolonged QT interval."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Heart Rhythm (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.hrthm.2007.07.022"}], "href": "https://doi.org/10.1016/j.hrthm.2007.07.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17997361"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17997361"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Min Jiang, Mei Zhang, Daniel G Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "KCNE2 protein is expressed in ventricles of different species, and changes in its expression contribute to electrical remodeling in diseased hearts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circulation (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.CIR.0000124225.43852.50"}], "href": "https://doi.org/10.1161/01.CIR.0000124225.43852.50"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15066947"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15066947"}]}]}]}
Synonyms	MIRP1, ATFB4, LQT6
Proteins	KCNE2_HUMAN
NCBI Gene ID	9992
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

KCNE2 has 4,500 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 110 datasets.

Click the + buttons to view associations for KCNE2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

KCNE2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by KCNE2 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KCNE2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of KCNE2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of KCNE2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of KCNE2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of KCNE2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KCNE2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of KCNE2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of KCNE2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of KCNE2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of KCNE2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of KCNE2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of KCNE2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with KCNE2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of KCNE2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of KCNE2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of KCNE2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with KCNE2 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with KCNE2 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of KCNE2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing KCNE2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing KCNE2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with KCNE2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with KCNE2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of KCNE2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with KCNE2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with KCNE2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with KCNE2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by KCNE2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving KCNE2 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving KCNE2 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with KCNE2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with KCNE2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with KCNE2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with KCNE2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with KCNE2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at KCNE2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of KCNE2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of KCNE2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing KCNE2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.