HGNC Family | Ion channels |
Name | potassium channel, two pore domain subfamily K, member 18 |
Description | Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, osmotic regulation, and ion flow. This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains and the encoded protein functions as an outward rectifying potassium channel. A mutation in this gene has been found to be associated with migraine with aura.[provided by RefSeq, Jan 2011] |
Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n The KCNK18 gene encodes the two‐pore domain potassium channel TRESK, a background (“leak”) K⁺ channel that plays a critical role in setting the resting membrane potential and modulating cellular excitability. In sensory neurons, particularly in the trigeminal and dorsal root ganglia, TRESK provides an important inhibitory influence on neuronal firing, and loss‐of‐function mutations (such as the frameshift F139WfsX24 mutation) cause a dominant‐negative effect that enhances neuronal excitability and has been strongly linked to migraine with aura."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Cloning and electrophysiological studies confirmed that TRESK functions as a background K⁺ channel in the spinal cord and other excitable cells"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", while detailed analyses have demonstrated that its activity is regulated by calcium‐dependent signaling via calcineurin, with specific docking sites (including PQIIIS and LQLP motifs) and modulatory interactions with 14–3–3 proteins fine‐tuning its kinetics."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "7"}]}, {"type": "t", "text": " Species-specific properties, including pH sensitivity and posttranslational modifications like glycosylation, further contribute to the nuanced control of TRESK channel function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In addition to its role in neuronal excitability and migraine pathogenesis—as reviewed in several studies"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "—TRESK has been implicated in other physiological functions. For example, TRESK contributes to the background K⁺ currents that underlie regulatory volume decrease in T lymphocytes"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "and is expressed in lymphoblastic cells, suggesting a potential role in cell proliferation and tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": " Furthermore, in human induced pluripotent stem cell–derived nociceptors, TRESK loss caused by migraine-associated mutations increases neuronal firing, and pharmacological activation by agents such as cloxyquin can reduce hyperexcitability"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": ", while high-throughput screening has identified selective modulators of KCNK18/TRESK activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": " Structural studies have provided insights into TRESK’s channel architecture and key ligand–channel interactions that may guide future drug design."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": " Finally, genetic analyses in various populations indicate that although rare loss‐of‐function variants clearly impact migraine susceptibility"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": ", common polymorphisms in KCNK18 do not appear to have a significant effect. Notably, emerging evidence also suggests a role for TRESK in modulating network excitability in epilepsy via depolarization-induced shunting inhibition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": " Collectively, these studies underscore that TRESK, encoded by KCNK18, is a key regulator of cellular excitability in both neuronal and non-neuronal tissues, representing a promising therapeutic target for migraine, pain disorders, and potentially other conditions.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Additional network analyses have linked TRESK function to other migraine risk factors and ion channel interactions, further emphasizing its importance in neurophysiological homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "21", "end_ref": "23"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ronald G Lafrenière, M Zameel Cader, Jean-François Poulin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.2216"}], "href": "https://doi.org/10.1038/nm.2216"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20871611"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20871611"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhaohua Guo, Ping Liu, Fei Ren, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nonmigraine-associated TRESK K+ channel variant C110R does not increase the excitability of trigeminal ganglion neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurophysiol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/jn.00267.2014"}], "href": "https://doi.org/10.1152/jn.00267.2014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24805079"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24805079"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yorikata Sano, Kohei Inamura, Akira Miyake, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel two-pore domain K+ channel, TRESK, is localized in the spinal cord."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M206810200"}], "href": "https://doi.org/10.1074/jbc.M206810200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12754259"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12754259"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Gábor Czirják, Zsuzsanna E Tóth, Péter Enyedi "}, {"type": "b", "children": [{"type": "t", "text": "The two-pore domain K+ channel, TRESK, is activated by the cytoplasmic calcium signal through calcineurin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M312229200"}], "href": "https://doi.org/10.1074/jbc.M312229200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14981085"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14981085"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Gábor Czirják, Péter Enyedi "}, {"type": "b", "children": [{"type": "t", "text": "Targeting of calcineurin to an NFAT-like docking site is required for the calcium-dependent activation of the background K+ channel, TRESK."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M602495200"}], "href": "https://doi.org/10.1074/jbc.M602495200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16569637"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16569637"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Gábor Czirják, Drazsen Vuity, Péter Enyedi "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylation-dependent binding of 14-3-3 proteins controls TRESK regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M800712200"}], "href": "https://doi.org/10.1074/jbc.M800712200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18397886"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18397886"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Gábor Czirják, Péter Enyedi "}, {"type": "b", "children": [{"type": "t", "text": "The LQLP calcineurin docking site is a major determinant of the calcium-dependent activation of human TRESK background K+ channel."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.577684"}], "href": "https://doi.org/10.1074/jbc.M114.577684"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25202008"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25202008"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Tina Dobler, Andreas Springauf, Stefanie Tovornik, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRESK two-pore-domain K+ channels constitute a significant component of background potassium currents in murine dorsal root ganglion neurones."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Physiol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1113/jphysiol.2007.145649"}], "href": "https://doi.org/10.1113/jphysiol.2007.145649"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17962323"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17962323"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Brigitte Egenberger, Georg Polleichtner, Erhard Wischmeyer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "N-linked glycosylation determines cell surface expression of two-pore-domain K+ channel TRESK."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2009.12.056"}], "href": "https://doi.org/10.1016/j.bbrc.2009.12.056"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20006580"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20006580"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Ronald G Lafrenière, Guy A Rouleau "}, {"type": "b", "children": [{"type": "t", "text": "Migraine: Role of the TRESK two-pore potassium channel."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biochem Cell Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biocel.2011.08.002"}], "href": "https://doi.org/10.1016/j.biocel.2011.08.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21855646"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21855646"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Péter Enyedi, Gabriella Braun, Gábor Czirják "}, {"type": "b", "children": [{"type": "t", "text": "TRESK: the lone ranger of two-pore domain potassium channels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Endocrinol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mce.2011.11.009"}], "href": "https://doi.org/10.1016/j.mce.2011.11.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22115960"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22115960"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Nicole Bobak, Stefan Bittner, Joseph Andronic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Volume regulation of murine T lymphocytes relies on voltage-dependent and two-pore domain potassium channels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamem.2011.04.013"}], "href": "https://doi.org/10.1016/j.bbamem.2011.04.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21575593"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21575593"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Igor I Pottosin, Edgar Bonales-Alatorre, Georgina Valencia-Cruz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRESK-like potassium channels in leukemic T cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pflugers Arch (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00424-008-0481-x"}], "href": "https://doi.org/10.1007/s00424-008-0481-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18506476"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18506476"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Dénison Selene Sánchez-Miguel, Fernando García-Dolores, María Rosa Flores-Márquez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRESK potassium channel in human T lymphoblasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2013.02.115"}], "href": "https://doi.org/10.1016/j.bbrc.2013.02.115"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23541583"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23541583"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Philippa Pettingill, Greg A Weir, Tina Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A causal role for TRESK loss of function in migraine mechanisms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/brain/awz342"}], "href": "https://doi.org/10.1093/brain/awz342"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31742594"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31742594"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "J Kyle Bruner, Beiyan Zou, Hongkang Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of novel small molecule modulators of K2P18.1 two-pore potassium channel."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Pharmacol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejphar.2014.06.021"}], "href": "https://doi.org/10.1016/j.ejphar.2014.06.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24972239"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24972239"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Songmi Kim, Yuno Lee, Hyun-Min Tak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of blocker binding site in mouse TRESK by molecular modeling and mutational studies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamem.2012.11.021"}], "href": "https://doi.org/10.1016/j.bbamem.2012.11.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23200789"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23200789"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Innocenzo Rainero, Elisa Rubino, Salvatore Gallone, et al. "}, {"type": "b", "children": [{"type": "t", "text": "KCNK18 (TRESK) genetic variants in Italian patients with migraine."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Headache (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/head.12439"}], "href": "https://doi.org/10.1111/head.12439"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25324165"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25324165"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "B H Maher, M Taylor, S Stuart, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of 3 common polymorphisms in the KCNK18 gene in an Australian Migraine case-control cohort."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2013.07.030"}], "href": "https://doi.org/10.1016/j.gene.2013.07.030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23911303"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23911303"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Weiyuan Huang, Yue Ke, Jianping Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRESK channel contributes to depolarization-induced shunting inhibition and modulates epileptic seizures."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2021.109404"}], "href": "https://doi.org/10.1016/j.celrep.2021.109404"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34289346"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34289346"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Perrine Royal, Alba Andres-Bilbe, Pablo Ávalos Prado, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Migraine-Associated TRESK Mutations Increase Neuronal Excitability through Alternative Translation Initiation and Inhibition of TREK."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuron (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuron.2018.11.039"}], "href": "https://doi.org/10.1016/j.neuron.2018.11.039"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30573346"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30573346"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Maria Tropeano, Ciçek Wöber-Bingöl, Andreas Karwautz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association analysis of STX1A gene variants in common forms of migraine."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cephalalgia (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/0333102411433300"}], "href": "https://doi.org/10.1177/0333102411433300"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22250207"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22250207"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Hariharan Subramanian, Frank Döring, Sina Kollert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PTH1R Mutants Found in Patients with Primary Failure of Tooth Eruption Disrupt G-Protein Signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0167033"}], "href": "https://doi.org/10.1371/journal.pone.0167033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27898723"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27898723"}]}]}]}
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Synonyms | MGR13, TRESK-2, TRIK, TRESK, TRESK2, K2P18.1 |
Proteins | KCNKI_HUMAN |
NCBI Gene ID | 338567 |
API | |
Download Associations | |
Predicted Functions |
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Co-expressed Genes |
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Expression in Tissues and Cell Lines |
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KCNK18 has 1,639 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 77 datasets.
Click the + buttons to view associations for KCNK18 from the datasets below.
If available, associations are ranked by standardized value
Dataset | Summary | |
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Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of KCNK18 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of KCNK18 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of KCNK18 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of KCNK18 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of KCNK18 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of KCNK18 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
ChEA Transcription Factor Targets | transcription factors binding the promoter of KCNK18 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of KCNK18 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing KCNK18 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing KCNK18 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with KCNK18 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with KCNK18 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of KCNK18 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
COSMIC Cell Line Gene Mutation Profiles | cell lines with KCNK18 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
CTD Gene-Chemical Interactions | chemicals interacting with KCNK18 gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
CTD Gene-Disease Associations | diseases associated with KCNK18 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
DepMap CRISPR Gene Dependency | cell lines with fitness changed by KCNK18 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with KCNK18 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with KCNK18 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with KCNK18 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DisGeNET Gene-Disease Associations | diseases associated with KCNK18 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
DisGeNET Gene-Phenotype Associations | phenotypes associated with KCNK18 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at KCNK18 gene from the ENCODE Histone Modification Site Profiles dataset. | |
ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of KCNK18 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
ENCODE Transcription Factor Targets | transcription factors binding the promoter of KCNK18 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing KCNK18 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
GAD Gene-Disease Associations | diseases associated with KCNK18 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
GeneRIF Biological Term Annotations | biological terms co-occuring with KCNK18 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of KCNK18 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of KCNK18 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of KCNK18 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
GO Biological Process Annotations 2015 | biological processes involving KCNK18 gene from the curated GO Biological Process Annotations 2015 dataset. | |
GO Biological Process Annotations 2023 | biological processes involving KCNK18 gene from the curated GO Biological Process Annotations 2023 dataset. | |
GO Biological Process Annotations 2025 | biological processes involving KCNK18 gene from the curated GO Biological Process Annotations2025 dataset. | |
GO Cellular Component Annotations 2015 | cellular components containing KCNK18 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
GO Molecular Function Annotations 2015 | molecular functions performed by KCNK18 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
GO Molecular Function Annotations 2023 | molecular functions performed by KCNK18 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
GO Molecular Function Annotations 2025 | molecular functions performed by KCNK18 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
GTEx Tissue Gene Expression Profiles | tissues with high or low expression of KCNK18 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of KCNK18 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
Guide to Pharmacology Chemical Ligands of Receptors | ligands (chemical) binding KCNK18 receptor from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset. | |
GWASdb SNP-Disease Associations | diseases associated with KCNK18 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
GWASdb SNP-Phenotype Associations | phenotypes associated with KCNK18 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of KCNK18 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
HPA Tissue Protein Expression Profiles | tissues with high or low expression of KCNK18 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
Hub Proteins Protein-Protein Interactions | interacting hub proteins for KCNK18 from the curated Hub Proteins Protein-Protein Interactions dataset. | |
HuGE Navigator Gene-Phenotype Associations | phenotypes associated with KCNK18 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
IMPC Knockout Mouse Phenotypes | phenotypes of mice caused by KCNK18 gene knockout from the IMPC Knockout Mouse Phenotypes dataset. | |
InterPro Predicted Protein Domain Annotations | protein domains predicted for KCNK18 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of KCNK18 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
KEA Substrates of Kinases | kinases that phosphorylate KCNK18 protein from the curated KEA Substrates of Kinases dataset. | |
Kinase Library Serine Threonine Kinome Atlas | kinases that phosphorylate KCNK18 protein from the Kinase Library Serine Threonine Atlas dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of KCNK18 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of KCNK18 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain KCNK18 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by KCNK18 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
MiRTarBase microRNA Targets | microRNAs targeting KCNK18 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of KCNK18 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by KCNK18 gene mutations from the MPO Gene-Phenotype Associations dataset. | |
OMIM Gene-Disease Associations | phenotypes associated with KCNK18 gene from the curated OMIM Gene-Disease Associations dataset. | |
Pathway Commons Protein-Protein Interactions | interacting proteins for KCNK18 from the Pathway Commons Protein-Protein Interactions dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of KCNK18 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PFOCR Pathway Figure Associations 2023 | pathways involving KCNK18 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
PFOCR Pathway Figure Associations 2024 | pathways involving KCNK18 protein from the Wikipathways PFOCR 2024 dataset. | |
Phosphosite Textmining Biological Term Annotations | biological terms co-occuring with KCNK18 protein in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset. | |
PhosphoSitePlus Substrates of Kinases | kinases that phosphorylate KCNK18 protein from the curated PhosphoSitePlus Substrates of Kinases dataset. | |
Reactome Pathways 2014 | pathways involving KCNK18 protein from the Reactome Pathways dataset. | |
Reactome Pathways 2024 | pathways involving KCNK18 protein from the Reactome Pathways 2024 dataset. | |
Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at KCNK18 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of KCNK18 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of KCNK18 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of KCNK18 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of KCNK18 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of KCNK18 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of KCNK18 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with KCNK18 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with KCNK18 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |