KCTD10 Gene

HGNC Family	BTB (POZ) domain containing (BTBD)
Name	potassium channel tetramerization domain containing 10
Description	The protein encoded by this gene binds proliferating cell nuclear antigen (PCNA) and may be involved in DNA synthesis and cell proliferation. In addition, the encoded protein may be a tumor suppressor. Several protein-coding and non-protein coding transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n KCTD10 is a multifunctional protein belonging to the PDIP1 family that plays pivotal roles in ubiquitin‐dependent protein turnover and thereby regulates diverse cellular processes. For example, KCTD10 acts as a substrate‐recognition adaptor for the Cullin‐3 E3 ubiquitin ligase complex, directing the polyubiquitination and subsequent degradation of proteins such as RhoB and CEP97. This activity is critical for maintaining proper endothelial barrier function, modulating plasma membrane dynamics, and ensuring efficient ciliogenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the cardiovascular system, KCTD10 is rapidly induced by vascular endothelial growth factor and is essential for embryonic angiogenesis and heart development. Genetic ablation in mice or knockdown in zebrafish leads to severe cardiac malformations, including disrupted heart looping, pericardial edema, and impaired vascular formation. These studies indicate that KCTD10 modulates Notch signaling, in part through interactions with Notch1 and Tbx5, thereby serving as a negative regulator of this pathway during cardiac morphogenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n KCTD10 also contributes to cellular proliferation and DNA synthesis through its interaction with proliferating cell nuclear antigen (PCNA), and its expression levels have been implicated in tumor suppression. In gastrointestinal stromal tumors, for instance, reduced KCTD10 expression correlates with increased cell proliferation and invasive potential, suggesting a tumor‐suppressive role."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, genetic association studies have linked single nucleotide polymorphisms in KCTD10 to variations in lipid profiles and coronary heart disease risk, while functional studies suggest that KCTD10 may influence metabolic homeostasis in tissues such as brown adipose tissue via modulation of Notch signaling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "14"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, emerging evidence indicates that KCTD10 might contribute to neurodevelopment and repigmentation processes, as altered expression has been observed in neural tissues and in melanocyte precursor biology in vitiligo, suggesting roles in cell migration and differentiation in these contexts."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "17"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings underscore that KCTD10 functions as a key regulator of protein ubiquitination that impacts endothelial barrier integrity, cardiac development, lipid metabolism, tumor suppression, and possibly neurodevelopment and skin repigmentation, making it a multifunctional protein with significant implications for human disease.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Igor Kovačević, Tomohisa Sakaue, Jisca Majoleé, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Cullin-3-Rbx1-KCTD10 complex controls endothelial barrier function via K63 ubiquitination of RhoB."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201606055"}], "href": "https://doi.org/10.1083/jcb.201606055"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29358211"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29358211"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Akari Murakami, Masashi Maekawa, Katsuhisa Kawai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cullin-3/KCTD10 E3 complex is essential for Rac1 activation through RhoB degradation in human epidermal growth factor receptor 2-positive breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.13899"}], "href": "https://doi.org/10.1111/cas.13899"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30515933"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30515933"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Tomoaki Nagai, Sachiho Mukoyama, Harumi Kagiwada, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cullin-3-KCTD10-mediated CEP97 degradation promotes primary cilium formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.219527"}], "href": "https://doi.org/10.1242/jcs.219527"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30404837"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30404837"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Masashi Maekawa, Shigeki Higashiyama "}, {"type": "b", "children": [{"type": "t", "text": "KCTD10 Biology: An Adaptor for the Ubiquitin E3 Complex Meets Multiple Substrates: Emerging Divergent Roles of the cullin-3/KCTD10 E3 Ubiquitin Ligase Complex in Various Cell Lines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioessays (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/bies.201900256"}], "href": "https://doi.org/10.1002/bies.201900256"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32484264"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32484264"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Kaiqun Ren, Jing Yuan, Manjun Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "KCTD10 is involved in the cardiovascular system and Notch signaling during early embryonic development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0112275"}], "href": "https://doi.org/10.1371/journal.pone.0112275"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25401743"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25401743"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xiangjun Tong, Yao Zu, Zengpeng Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Kctd10 regulates heart morphogenesis by repressing the transcriptional activity of Tbx5a in zebrafish."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms4153"}], "href": "https://doi.org/10.1038/ncomms4153"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24430697"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24430697"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Xiang Hu, Shiquan Gan, Guie Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "KCTD10 is critical for heart and blood vessel development of zebrafish."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Biochim Biophys Sin (Shanghai) (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/abbs/gmu017"}], "href": "https://doi.org/10.1093/abbs/gmu017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24705121"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24705121"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Xue-Feng Pang, Xue Lin, Jian-Jun Du, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of microRNA-592 protects mice from hypoplastic heart and congenital heart disease by inhibition of the Notch signaling pathway through upregulating KCTD10."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.27190"}], "href": "https://doi.org/10.1002/jcp.27190"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30478832"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30478832"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yibo Wang, Yi Zheng, Fang Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "KCTD10 interacts with proliferating cell nuclear antigen and its down-regulation could inhibit cell proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.22026"}], "href": "https://doi.org/10.1002/jcb.22026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19125419"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19125419"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Daisuke Kubota, Akihiko Yoshida, Hitoshi Tsuda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gene expression network analysis of ETV1 reveals KCTD10 as a novel prognostic biomarker in gastrointestinal stromal tumor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0073896"}], "href": "https://doi.org/10.1371/journal.pone.0073896"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23977394"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23977394"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Xiang Hu, Feng Yan, Fangmei Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TNFAIP1 interacts with KCTD10 to promote the degradation of KCTD10 proteins and inhibit the transcriptional activities of NF-κB and AP-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Rep (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11033-012-1858-7"}], "href": "https://doi.org/10.1007/s11033-012-1858-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22810651"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22810651"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Mireia Junyent, Laurence D Parnell, Chao-Qiang Lai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel variants at KCTD10, MVK, and MMAB genes interact with dietary carbohydrates to modulate HDL-cholesterol concentrations in the Genetics of Lipid Lowering Drugs and Diet Network Study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Clin Nutr (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3945/ajcn.2009.27738"}], "href": "https://doi.org/10.3945/ajcn.2009.27738"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19605566"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19605566"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Jie Sun, Yun Qian, Yue Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of KCTD10, MVK, and MMAB polymorphisms with dyslipidemia and coronary heart disease in Han Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lipids Health Dis (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12944-016-0348-7"}], "href": "https://doi.org/10.1186/s12944-016-0348-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27716295"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27716295"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Ming-Sheng Ye, Liping Luo, Qi Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "KCTD10 regulates brown adipose tissue thermogenesis and metabolic function via Notch signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Endocrinol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1530/JOE-21-0016"}], "href": "https://doi.org/10.1530/JOE-21-0016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34854382"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34854382"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Ivan Gladwyn-Ng, Lieven Huang, Linh Ngo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bacurd1/Kctd13 and Bacurd2/Tnfaip1 are interacting partners to Rnd proteins which influence the long-term positioning and dendritic maturation of cerebral cortical neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neural Dev (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13064-016-0062-1"}], "href": "https://doi.org/10.1186/s13064-016-0062-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26969432"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26969432"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Ji-Kang Sun, Bo Zhang, Jian Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Preparation of mouse KCTD10 antibody and expression analysis of KCTD10 in neuroepithelium of neural tube and dorsal root ganglion]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sheng Wu Gong Cheng Xue Bao (2007)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18257228"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18257228"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Nathaniel B Goldstein, Andrea Steel, Chauncey C Barbulescu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Melanocyte Precursors in the Hair Follicle Bulge of Repigmented Vitiligo Skin Are Controlled by RHO-GTPase, KCTD10, and CTNNB1 Signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jid.2020.07.016"}], "href": "https://doi.org/10.1016/j.jid.2020.07.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32800877"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32800877"}]}]}]}
Synonyms	HBACURD3, MSTP028, ULRO61, BTBD28
Proteins	BACD3_HUMAN
NCBI Gene ID	83892
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

KCTD10 has 5,126 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 112 datasets.

Click the + buttons to view associations for KCTD10 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

KCTD10 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by KCTD10 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KCTD10 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of KCTD10 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of KCTD10 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of KCTD10 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of KCTD10 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KCTD10 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of KCTD10 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of KCTD10 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of KCTD10 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of KCTD10 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with KCTD10 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with KCTD10 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of KCTD10 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of KCTD10 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of KCTD10 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing KCTD10 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing KCTD10 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing KCTD10 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing KCTD10 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with KCTD10 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with KCTD10 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of KCTD10 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with KCTD10 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with KCTD10 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with KCTD10 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of KCTD10 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with KCTD10 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with KCTD10 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with KCTD10 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with KCTD10 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with KCTD10 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with KCTD10 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at KCTD10 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of KCTD10 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of KCTD10 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing KCTD10 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with KCTD10 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with KCTD10 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing KCTD10 from the GeneSigDB Published Gene Signatures dataset.