KDM6A Gene

HGNC Family	Tetratricopeptide repeat domain containing (TTC), Chromatin-modifying enzymes
Name	lysine (K)-specific demethylase 6A
Description	This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n KDM6A (also known as UTX) encodes a histone demethylase that specifically removes the repressive trimethyl mark on histone H3 lysine 27 (H3K27me3), thereby facilitating chromatin opening and transcriptional activation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n During normal development and cellular reprogramming, KDM6A plays a crucial role in removing H3K27me3 at key regulatory loci – including HOX gene clusters – to promote lineage commitment and the induction of pluripotency. In model systems ranging from zebrafish to mammalian cells, its activity has been shown to be required for the derepression of developmental genes and for proper differentiation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}, {"type": "fg_fs", "start_ref": "5", "end_ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the context of human disease, loss-of-function mutations, deletions, or other inactivating alterations of KDM6A have been identified in a spectrum of cancers—including certain lymphomas, renal cell carcinomas, and T‐cell acute lymphoblastic leukemia—as well as in virus‐associated neoplasms. These findings support a tumor‐suppressive role for KDM6A, as its inactivation leads to the persistence of repressive chromatin marks and aberrant gene silencing."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_fs", "start_ref": "9", "end_ref": "14"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, KDM6A collaborates with chromatin remodeling partners—including complexes containing MLL/SET family methyltransferases and PTIP-associated factors—to couple the removal of repressive H3K27me3 with the establishment of active histone modifications, thus ensuring coordinated transcriptional regulation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "17"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, genetic alterations affecting KDM6A are implicated in congenital disorders such as Kabuki syndrome, underscoring its essential role in normal developmental programs."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies indicate that KDM6A is an essential epigenetic regulator that integrates environmental cues – such as oxygen levels, which directly impact its activity – with chromatin remodeling to control gene expression. Disruption of KDM6A function, whether by mutation or altered regulation, contributes to aberrant cellular differentiation and tumorigenesis by maintaining repressive chromatin landscapes.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ryan D Morin, Nathalie A Johnson, Tesa M Severson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.518"}], "href": "https://doi.org/10.1038/ng.518"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20081860"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20081860"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Karl Agger, Paul A C Cloos, Jesper Christensen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature06145"}], "href": "https://doi.org/10.1038/nature06145"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17713478"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17713478"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Sunhwa Hong, Young-Wook Cho, Li-Rong Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0707292104"}], "href": "https://doi.org/10.1073/pnas.0707292104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18003914"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18003914"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Abhishek A Chakraborty, Tuomas Laukka, Matti Myllykoski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.aaw1026"}], "href": "https://doi.org/10.1126/science.aaw1026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30872525"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30872525"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Fei Lan, Peter E Bayliss, John L Rinn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A histone H3 lysine 27 demethylase regulates animal posterior development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature06192"}], "href": "https://doi.org/10.1038/nature06192"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17851529"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17851529"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Min Gyu Lee, Raffaella Villa, Patrick Trojer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1149042"}], "href": "https://doi.org/10.1126/science.1149042"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17761849"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17761849"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Abed AlFatah Mansour, Ohad Gafni, Leehee Weinberger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature11272"}], "href": "https://doi.org/10.1038/nature11272"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22801502"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22801502"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Karl B Shpargel, Toru Sengoku, Shigeyuki Yokoyama, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1002964"}], "href": "https://doi.org/10.1371/journal.pgen.1002964"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23028370"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23028370"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Ignacio Varela, Patrick Tarpey, Keiran Raine, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature09639"}], "href": "https://doi.org/10.1038/nature09639"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21248752"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21248752"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Gillian L Dalgliesh, Kyle Furge, Chris Greenman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature08672"}], "href": "https://doi.org/10.1038/nature08672"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20054297"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20054297"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Gijs van Haaften, Gillian L Dalgliesh, Helen Davies, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.349"}], "href": "https://doi.org/10.1038/ng.349"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19330029"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19330029"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Panagiotis Ntziachristos, Aristotelis Tsirigos, G Grant Welstead, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature13605"}], "href": "https://doi.org/10.1038/nature13605"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25132549"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25132549"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Margaret E McLaughlin-Drubin, Christopher P Crum, Karl Münger "}, {"type": "b", "children": [{"type": "t", "text": "Human papillomavirus E7 oncoprotein induces KDM6A and KDM6B histone demethylase expression and causes epigenetic reprogramming."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1009933108"}], "href": "https://doi.org/10.1073/pnas.1009933108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21245294"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21245294"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Andrew Dunford, David M Weinstock, Virginia Savova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor-suppressor genes that escape from X-inactivation contribute to cancer sex bias."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.3726"}], "href": "https://doi.org/10.1038/ng.3726"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27869828"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27869828"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Young-Wook Cho, Teresa Hong, Sunhwa Hong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M701574200"}], "href": "https://doi.org/10.1074/jbc.M701574200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17500065"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17500065"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Irina Issaeva, Yulia Zonis, Tanya Rozovskaia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01506-06"}], "href": "https://doi.org/10.1128/MCB.01506-06"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17178841"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17178841"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Sara A Miller, Sarah E Mohn, Amy S Weinmann "}, {"type": "b", "children": [{"type": "t", "text": "Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2010.10.028"}], "href": "https://doi.org/10.1016/j.molcel.2010.10.028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21095589"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21095589"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Damien Lederer, Bernard Grisart, Maria Cristina Digilio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deletion of KDM6A, a histone demethylase interacting with MLL2, in three patients with Kabuki syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2011.11.021"}], "href": "https://doi.org/10.1016/j.ajhg.2011.11.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22197486"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22197486"}]}]}]}
Synonyms	KABUK2, BA386N14.2, UTX
Proteins	KDM6A_HUMAN
NCBI Gene ID	7403
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

KDM6A has 10,820 functional associations with biological entities spanning 8 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 116 datasets.

Click the + buttons to view associations for KDM6A from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

KDM6A Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KDM6A gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of KDM6A gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of KDM6A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of KDM6A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KDM6A gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of KDM6A gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of KDM6A gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of KDM6A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of KDM6A gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with KDM6A gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with KDM6A protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with KDM6A gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of KDM6A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of KDM6A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of KDM6A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with KDM6A gene from the curated ClinVar Gene-Phenotype Associations dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of KDM6A gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing KDM6A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing KDM6A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing KDM6A protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing KDM6A protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with KDM6A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with KDM6A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing KDM6A protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of KDM6A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with KDM6A gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with KDM6A gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with KDM6A gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of KDM6A protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by KDM6A gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving KDM6A gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving KDM6A gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with KDM6A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with KDM6A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with KDM6A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with KDM6A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at KDM6A gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of KDM6A gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of KDM6A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing KDM6A from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.