KEAP1 Gene

HGNC Family	BTB (POZ) domain containing (BTBD), Kelch-like (KLHL)
Name	kelch-like ECH-associated protein 1
Description	This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n KEAP1 plays a central role in maintaining cellular redox balance by acting as a molecular “gatekeeper” for the transcription factor Nrf2. Under basal conditions, KEAP1 functions as a substrate adaptor for the Cul3–Rbx1 E3 ubiquitin ligase complex, binding directly to Nrf2’s Neh2 domain via a high‐affinity ETGE motif and a lower‐affinity DLG motif to promote its ubiquitination and rapid proteasomal degradation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " In response to oxidative or electrophilic stress, key cysteine residues within KEAP1 (for example, Cys151, Cys273, and Cys288) become covalently modified, which impairs its E3 ligase function and allows de novo–synthesized Nrf2 to escape degradation. The stabilized Nrf2 then accumulates in the nucleus and activates the expression of an array of cytoprotective genes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "8"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to redox‐induced modifications, KEAP1 function can be modulated by protein–protein interactions. For instance, the autophagy adaptor protein p62 competes with Nrf2 for KEAP1 binding, sequestering KEAP1 and thereby promoting Nrf2 stabilization and activation, particularly when autophagic flux is impaired."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "11"}]}, {"type": "t", "text": " Moreover, metabolic intermediates such as itaconate and fumarate directly modify KEAP1 cysteine residues, further illustrating its role as a sensor that integrates intracellular stress signals."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Disruption of KEAP1 function—whether by stress‐induced cysteine modification, competitive interactions, or somatic mutations (as observed in various cancers including non–small cell lung carcinoma)—leads to constitutive Nrf2 activation. Such sustained Nrf2 activity confers resistance to oxidative stress and chemotherapeutic agents by upregulating detoxification enzymes, drug efflux pumps, and other prosurvival pathways."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "16"}]}, {"type": "t", "text": " Furthermore, factors such as p21 may also modulate the KEAP1–Nrf2 interaction, adding another layer to the regulation of the antioxidant response."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, the studies reviewed here underscore a dual role for KEAP1 as both a critical adaptor for targeting Nrf2 for degradation and as a redox-sensitive sensor that coordinates adaptive transcriptional responses to environmental and metabolic stressors. This balance ensures cytoprotection under normal conditions, while its disruption may contribute to pathological states such as oncogenesis and chemoresistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}, {"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Akira Kobayashi, Moon-Il Kang, Hiromi Okawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.24.16.7130-7139.2004"}], "href": "https://doi.org/10.1128/MCB.24.16.7130-7139.2004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15282312"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15282312"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Donna D Zhang, Shih-Ching Lo, Janet V Cross, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.24.24.10941-10953.2004"}], "href": "https://doi.org/10.1128/MCB.24.24.10941-10953.2004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15572695"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15572695"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Balasundaram Padmanabhan, Kit I Tong, Tsutomu Ohta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2006.01.013"}], "href": "https://doi.org/10.1016/j.molcel.2006.01.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16507366"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16507366"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Truyen Nguyen, Paul Nioi, Cecil B Pickett "}, {"type": "b", "children": [{"type": "t", "text": "The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.R900010200"}], "href": "https://doi.org/10.1074/jbc.R900010200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19182219"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19182219"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Albena T Dinkova-Kostova, W David Holtzclaw, Robert N Cole, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.172398899"}], "href": "https://doi.org/10.1073/pnas.172398899"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12193649"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12193649"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Akira Kobayashi, Moon-Il Kang, Yoriko Watai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.26.1.221-229.2006"}], "href": "https://doi.org/10.1128/MCB.26.1.221-229.2006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16354693"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16354693"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Mi-Kyoung Kwak, Nobunao Wakabayashi, Ken Itoh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M211898200"}], "href": "https://doi.org/10.1074/jbc.M211898200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12506115"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12506115"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Julie Adam, Emine Hatipoglu, Linda O'Flaherty, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccr.2011.09.006"}], "href": "https://doi.org/10.1016/j.ccr.2011.09.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22014577"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22014577"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Masaaki Komatsu, Hirofumi Kurokawa, Satoshi Waguri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb2021"}], "href": "https://doi.org/10.1038/ncb2021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20173742"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20173742"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Ashish Jain, Trond Lamark, Eva Sjøttem, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.118976"}], "href": "https://doi.org/10.1074/jbc.M110.118976"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20452972"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20452972"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yoshihiro Inami, Satoshi Waguri, Ayako Sakamoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201102031"}], "href": "https://doi.org/10.1083/jcb.201102031"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21482715"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21482715"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Gina M DeNicola, Florian A Karreth, Timothy J Humpton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature10189"}], "href": "https://doi.org/10.1038/nature10189"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21734707"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21734707"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Tsutomu Ohta, Kumiko Iijima, Mamiko Miyamoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-07-5003"}], "href": "https://doi.org/10.1158/0008-5472.CAN-07-5003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18316592"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18316592"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Suryakant K Niture, Raju Khatri, Anil K Jaiswal "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of Nrf2-an update."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Free Radic Biol Med (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.freeradbiomed.2013.02.008"}], "href": "https://doi.org/10.1016/j.freeradbiomed.2013.02.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23434765"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23434765"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "S Chowdhry, Y Zhang, M McMahon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2012.388"}], "href": "https://doi.org/10.1038/onc.2012.388"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22964642"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22964642"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Dongmei Ren, Nicole F Villeneuve, Tao Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1014275108"}], "href": "https://doi.org/10.1073/pnas.1014275108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21205897"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21205897"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Weimin Chen, Zheng Sun, Xiao-Jun Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2009.04.029"}], "href": "https://doi.org/10.1016/j.molcel.2009.04.029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19560419"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19560419"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Keiko Taguchi, Hozumi Motohashi, Masayuki Yamamoto "}, {"type": "b", "children": [{"type": "t", "text": "Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Cells (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1365-2443.2010.01473.x"}], "href": "https://doi.org/10.1111/j.1365-2443.2010.01473.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21251164"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21251164"}]}]}]}
Synonyms	INRF2, KLHL19
Proteins	KEAP1_HUMAN
NCBI Gene ID	9817
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

KEAP1 has 14,736 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 124 datasets.

Click the + buttons to view associations for KEAP1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

KEAP1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KEAP1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of KEAP1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of KEAP1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of KEAP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of KEAP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KEAP1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving KEAP1 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of KEAP1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of KEAP1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of KEAP1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of KEAP1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of KEAP1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of KEAP1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with KEAP1 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of KEAP1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of KEAP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of KEAP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing KEAP1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of KEAP1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing KEAP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing KEAP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing KEAP1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing KEAP1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with KEAP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with KEAP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing KEAP1 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of KEAP1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with KEAP1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with KEAP1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with KEAP1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of KEAP1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by KEAP1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving KEAP1 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with KEAP1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with KEAP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with KEAP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with KEAP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with KEAP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for KEAP1 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at KEAP1 gene from the ENCODE Histone Modification Site Profiles dataset.