KHDRBS1 Gene

Name	KH domain containing, RNA binding, signal transduction associated 1
Description	This gene encodes a member of the K homology domain-containing, RNA-binding, signal transduction-associated protein family. The encoded protein appears to have many functions and may be involved in a variety of cellular processes, including alternative splicing, cell cycle regulation, RNA 3'-end formation, tumorigenesis, and regulation of human immunodeficiency virus gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n KHDRBS1 (also known as Sam68) is a multifunctional RNA‐binding protein that acts as a signal transducer linking extracellular cues to multiple aspects of RNA metabolism—most notably alternative splicing, but also mRNA export and translation. Sam68 contains a KH domain that enables it to bind specific RNA elements and regulate splice‐site selection in key transcripts involved in cell cycle control, apoptosis, differentiation, and oncogenesis. For example, Sam68 is directly phosphorylated by kinases downstream of the ERK and Src pathways; this post‐translational modification modulates its RNA binding and subcellular localization, thereby promoting the inclusion of alternatively spliced exons in genes such as CD44, Bcl‑x, and cyclin D1."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In several disease contexts, including neurodegenerative disorders like fragile X‑associated tremor/ataxia syndrome (FXTAS) and spinal muscular atrophy, Sam68 function is disrupted either through sequestration by expanded CGG repeats or aberrant splicing regulation of critical pre‑mRNAs."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Additionally, Sam68 participates in oncogenic transcription complexes—often in association with protein arginine methyltransferases—and its regulated activity influences processes such as proliferation, cell survival and cell differentiation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "9"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its canonical role in splicing regulation, Sam68 is also essential in developmental processes, as underscored by its function in neurogenesis and spermatogenesis, where it governs the expression and proper translation of mRNAs required for cell fate determination."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Its involvement in the regulation of alternative splicing extends to settings of signal‐dependent transitions in cellular phenotype, as seen in activity‐dependent splicing of neuronal receptors and in epithelial–mesenchymal transition programs."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Sam68 also interacts with other splicing regulators and adaptor proteins, including its cooperation with SR coactivators and competition with hnRNP proteins, thereby fine‑tuning splice site selection. In pathological settings such as certain cancers and viral infections, its activity is further modulated by tyrosine phosphorylation via kinases like BRK, which in turn affects its subcellular distribution and function in RNA utilization."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "17"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, emerging evidence indicates that Sam68 contributes to metabolic and differentiation processes, such as adipogenesis, by regulating alternative splicing decisions that impact signaling pathways like mTOR. Its interaction with long non‑coding RNAs and other ribonucleoproteins in various cancer types further supports its role as an integrator of signal transduction and RNA processing."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "18", "end_ref": "20"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, KHDRBS1/Sam68 functions as a key regulator of alternative splicing and mRNA metabolism that integrates extracellular signals into post‑transcriptional gene regulation. Its dynamic interactions and modifications allow it to control critical cellular processes—ranging from cell cycle progression and apoptosis to differentiation and oncogenic transformation—thereby underscoring its importance in both normal physiology and disease (1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21).\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Nathalie Matter, Peter Herrlich, Harald König "}, {"type": "b", "children": [{"type": "t", "text": "Signal-dependent regulation of splicing via phosphorylation of Sam68."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature01153"}], "href": "https://doi.org/10.1038/nature01153"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12478298"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12478298"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Eric Batsché, Moshe Yaniv, Christian Muchardt "}, {"type": "b", "children": [{"type": "t", "text": "The human SWI/SNF subunit Brm is a regulator of alternative splicing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsmb1030"}], "href": "https://doi.org/10.1038/nsmb1030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16341228"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16341228"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Maria Paola Paronetto, Tilman Achsel, Autumn Massiello, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200701005"}], "href": "https://doi.org/10.1083/jcb.200701005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17371836"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17371836"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Maria Paola Paronetto, Manuela Cappellari, Roberta Busà, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alternative splicing of the cyclin D1 proto-oncogene is regulated by the RNA-binding protein Sam68."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-09-2788"}], "href": "https://doi.org/10.1158/0008-5472.CAN-09-2788"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20028857"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20028857"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Chantal Sellier, Frédérique Rau, Yilei Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sam68 sequestration and partial loss of function are associated with splicing alterations in FXTAS patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emboj.2010.21"}], "href": "https://doi.org/10.1038/emboj.2010.21"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20186122"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20186122"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Simona Pedrotti, Pamela Bielli, Maria Paola Paronetto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emboj.2010.19"}], "href": "https://doi.org/10.1038/emboj.2010.19"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20186123"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20186123"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Ngai Cheung, Li Chong Chan, Alex Thompson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein arginine-methyltransferase-dependent oncogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1642"}], "href": "https://doi.org/10.1038/ncb1642"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17891136"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17891136"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Rafal Swiercz, Maria D Person, Mark T Bedford "}, {"type": "b", "children": [{"type": "t", "text": "Ribosomal protein S2 is a substrate for mammalian PRMT3 (protein arginine methyltransferase 3)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20041466"}], "href": "https://doi.org/10.1042/BJ20041466"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15473865"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15473865"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Michael S Serfas, Angela L Tyner "}, {"type": "b", "children": [{"type": "t", "text": "Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Res (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3727/096504003108748438"}], "href": "https://doi.org/10.3727/096504003108748438"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12725532"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12725532"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Maria Paola Paronetto, Valeria Messina, Enrica Bianchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sam68 regulates translation of target mRNAs in male germ cells, necessary for mouse spermatogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200811138"}], "href": "https://doi.org/10.1083/jcb.200811138"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19380878"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19380878"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Geetanjali Chawla, Chia-Ho Lin, Areum Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sam68 regulates a set of alternatively spliced exons during neurogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01349-08"}], "href": "https://doi.org/10.1128/MCB.01349-08"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18936165"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18936165"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Takatoshi Iijima, Karen Wu, Harald Witte, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SAM68 regulates neuronal activity-dependent alternative splicing of neurexin-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2011.11.028"}], "href": "https://doi.org/10.1016/j.cell.2011.11.028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22196734"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22196734"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Cristina Valacca, Serena Bonomi, Emanuele Buratti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sam68 regulates EMT through alternative splicing-activated nonsense-mediated mRNA decay of the SF2/ASF proto-oncogene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201001073"}], "href": "https://doi.org/10.1083/jcb.201001073"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20876280"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20876280"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Chonghui Cheng, Phillip A Sharp "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of CD44 alternative splicing by SRm160 and its potential role in tumor cell invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.26.1.362-370.2006"}], "href": "https://doi.org/10.1128/MCB.26.1.362-370.2006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16354706"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16354706"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jason J Derry, Gail S Prins, Vera Ray, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1206465"}], "href": "https://doi.org/10.1038/sj.onc.1206465"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12833144"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12833144"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Kiven Erique Lukong, Daniel Larocque, Angela L Tyner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M505802200"}], "href": "https://doi.org/10.1074/jbc.M505802200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16179349"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16179349"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "John H Coyle, Brian W Guzik, Yeou-Cherng Bor, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sam68 enhances the cytoplasmic utilization of intron-containing RNA and is functionally regulated by the nuclear kinase Sik/BRK."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.23.1.92-103.2003"}], "href": "https://doi.org/10.1128/MCB.23.1.92-103.2003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12482964"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12482964"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Marc-Étienne Huot, Gillian Vogel, Amber Zabarauskas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Sam68 STAR RNA-binding protein regulates mTOR alternative splicing during adipogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2012.02.007"}], "href": "https://doi.org/10.1016/j.molcel.2012.02.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22424772"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22424772"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Xue Wang, Hongfei Yu, Wenjie Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The long non-coding RNA CYTOR drives colorectal cancer progression by interacting with NCL and Sam68."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12943-018-0860-7"}], "href": "https://doi.org/10.1186/s12943-018-0860-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30064438"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30064438"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Florian Heyd, Kristen W Lynch "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylation-dependent regulation of PSF by GSK3 controls CD45 alternative splicing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2010.09.013"}], "href": "https://doi.org/10.1016/j.molcel.2010.09.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20932480"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20932480"}]}]}]}
Synonyms	SAM68
Proteins	KHDR1_HUMAN
NCBI Gene ID	10657
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

KHDRBS1 has 12,175 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 127 datasets.

Click the + buttons to view associations for KHDRBS1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

KHDRBS1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by KHDRBS1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KHDRBS1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of KHDRBS1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of KHDRBS1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of KHDRBS1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of KHDRBS1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KHDRBS1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving KHDRBS1 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of KHDRBS1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of KHDRBS1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of KHDRBS1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of KHDRBS1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of KHDRBS1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of KHDRBS1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with KHDRBS1 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of KHDRBS1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of KHDRBS1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of KHDRBS1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of KHDRBS1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing KHDRBS1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing KHDRBS1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing KHDRBS1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with KHDRBS1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with KHDRBS1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing KHDRBS1 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of KHDRBS1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with KHDRBS1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with KHDRBS1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with KHDRBS1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of KHDRBS1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by KHDRBS1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with KHDRBS1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with KHDRBS1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with KHDRBS1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with KHDRBS1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at KHDRBS1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of KHDRBS1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of KHDRBS1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing KHDRBS1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of KHDRBS1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.