KHK Gene

Name	ketohexokinase (fructokinase)
Description	This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Ketohexokinase (KHK), also known as fructokinase, is the key enzyme that phosphorylates fructose to fructose‐1‐phosphate—the first and rate‐limiting step in fructose metabolism. Its activity is central to metabolic processing of dietary as well as endogenously formed fructose in several organs. In the liver, KHK exists as two alternatively spliced isoforms: the high‐affinity KHK‑C and the lower‐affinity KHK‑A. KHK‑C is predominantly expressed in hepatocytes and is responsible for rapid fructose metabolism that promotes lipogenesis, hepatic steatosis, and—in stressed myocardium—pathological fructose utilization ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "]. In contrast, in certain cancers such as hepatocellular carcinoma and breast cancer, a splice‐switch favors expression of KHK‑A. In these contexts, KHK‑A not only functions in fructose catabolism but also acts as a protein kinase: it translocates to the nucleus where it phosphorylates substrates (e.g., PRPS1 and YWHAH) to promote nucleotide synthesis and cell migration, thereby driving tumor progression and metastasis ["}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": "]. \n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the kidney, KHK‐dependent metabolism of fructose in proximal tubular cells leads to ATP depletion and uric acid generation that trigger oxidative stress and proinflammatory signaling. Such events contribute to diabetic nephropathy and renal injury induced by endogenous fructose production via the polyol pathway ["}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "8"}]}, {"type": "t", "text": "]. Likewise, in the hypothalamus, fructose metabolism through KHK participates in the regulation of vasopressin release, thereby linking fructose intake to water homeostasis during dehydration ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "].\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Genetic and pharmacological studies further reveal that inhibition or deletion of KHK protects against fructose‐induced metabolic derangements—including hyperglycemia, visceral obesity, and liver and intestinal injury—and can alleviate the clinical manifestations of conditions such as hereditary fructose intolerance, in which elevated intracellular fructose‐1‐phosphate leads to phosphate depletion and metabolic toxicity ["}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "14"}]}, {"type": "t", "text": "]. Moreover, emerging evidence shows that regulatory mechanisms such as alternative splicing—modulated by factors like A1CF—play an important role in determining the balance between KHK isoforms, further influencing tissue‐specific metabolic outcomes.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies underscore the multifaceted role of KHK in orchestrating fructose metabolism, with implications for energy homeostasis, lipid synthesis, inflammatory signaling, and oncogenic transformation. By integrating its canonical role in fructose phosphorylation with non‐canonical protein kinase activity in disease states, KHK represents an attractive target for interventions aimed at treating metabolic syndrome, diabetic complications, and certain cancers ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "].\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Peter Mirtschink, Jaya Krishnan, Fiona Grimm, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature14508"}], "href": "https://doi.org/10.1038/nature14508"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26083752"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26083752"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Miguel A Lanaspa, Laura G Sanchez-Lozada, Christina Cicerchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Uric acid stimulates fructokinase and accelerates fructose metabolism in the development of fatty liver."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0047948"}], "href": "https://doi.org/10.1371/journal.pone.0047948"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23112875"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23112875"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xinjian Li, Xu Qian, Li-Xia Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb3338"}], "href": "https://doi.org/10.1038/ncb3338"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27088854"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27088854"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jiyoung Kim, Jengmin Kang, Ye-Lim Kang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ketohexokinase-A acts as a nuclear protein kinase that mediates fructose-induced metastasis in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-020-19263-1"}], "href": "https://doi.org/10.1038/s41467-020-19263-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33116123"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33116123"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Daqian Xu, Xinjian Li, Fei Shao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The protein kinase activity of fructokinase A specifies the antioxidant responses of tumor cells by phosphorylating p62."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Adv (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/sciadv.aav4570"}], "href": "https://doi.org/10.1126/sciadv.aav4570"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31032410"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31032410"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Pietro Cirillo, Michael S Gersch, Wei Mu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Soc Nephrol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1681/ASN.2008060576"}], "href": "https://doi.org/10.1681/ASN.2008060576"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19158351"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19158351"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Miguel A Lanaspa, Takuji Ishimoto, Christina Cicerchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endogenous fructose production and fructokinase activation mediate renal injury in diabetic nephropathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Soc Nephrol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1681/ASN.2013080901"}], "href": "https://doi.org/10.1681/ASN.2013080901"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24876114"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24876114"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Carlos A Roncal Jimenez, Takuji Ishimoto, Miguel A Lanaspa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fructokinase activity mediates dehydration-induced renal injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Kidney Int (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ki.2013.492"}], "href": "https://doi.org/10.1038/ki.2013.492"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24336030"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24336030"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Zhilin Song 宋志林, Carlos A Roncal-Jimenez, Miguel A Lanaspa-Garcia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of fructose and fructokinase in acute dehydration-induced vasopressin gene expression and secretion in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurophysiol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/jn.00781.2016"}], "href": "https://doi.org/10.1152/jn.00781.2016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27852737"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27852737"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Miguel A Lanaspa, Ana Andres-Hernando, David J Orlicky, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI94427"}], "href": "https://doi.org/10.1172/JCI94427"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29533924"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29533924"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Chirag Patel, Keiichiro Sugimoto, Veronique Douard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effect of dietary fructose on portal and systemic serum fructose levels in rats and in KHK-/- and GLUT5-/- mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Gastrointest Liver Physiol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpgi.00188.2015"}], "href": "https://doi.org/10.1152/ajpgi.00188.2015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26316589"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26316589"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "George Marek, Varinderpal Pannu, Prashanth Shanmugham, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Adiponectin resistance and proinflammatory changes in the visceral adipose tissue induced by fructose consumption via ketohexokinase-dependent pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/db14-0411"}], "href": "https://doi.org/10.2337/db14-0411"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25187370"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25187370"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Kostas C Nikolaou, Hasan Vatandaslar, Cindy Meyer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The RNA-Binding Protein A1CF Regulates Hepatic Fructose and Glycerol Metabolism via Alternative RNA Splicing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2019.08.100"}], "href": "https://doi.org/10.1016/j.celrep.2019.08.100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31597092"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31597092"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Aruna Asipu, Bruce E Hayward, John O'Reilly, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Properties of normal and mutant recombinant human ketohexokinases and implications for the pathogenesis of essential fructosuria."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/diabetes.52.9.2426"}], "href": "https://doi.org/10.2337/diabetes.52.9.2426"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12941785"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12941785"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Takuji Ishimoto, Miguel A Lanaspa, Christopher J Rivard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.26594"}], "href": "https://doi.org/10.1002/hep.26594"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23813872"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23813872"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Chirag Patel, Veronique Douard, Shiyan Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fructose-induced increases in expression of intestinal fructolytic and gluconeogenic genes are regulated by GLUT5 and KHK."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Regul Integr Comp Physiol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpregu.00128.2015"}], "href": "https://doi.org/10.1152/ajpregu.00128.2015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26084694"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26084694"}]}]}]}
Proteins	KHK_HUMAN
NCBI Gene ID	3795
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

KHK has 7,064 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 122 datasets.

Click the + buttons to view associations for KHK from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

KHK Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KHK gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of KHK gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of KHK gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of KHK gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of KHK gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KHK gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of KHK gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of KHK gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of KHK gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of KHK gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of KHK gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of KHK gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with KHK protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with KHK gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of KHK gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of KHK gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of KHK gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with KHK gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with KHK gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of KHK gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of KHK gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing KHK protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing KHK protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with KHK protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with KHK protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of KHK gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with KHK gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with KHK gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with KHK gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of KHK protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by KHK gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DGIdb Drug Targets 2026	interacting drugs for KHK protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with KHK gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with KHK gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with KHK gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with KHK gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at KHK gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of KHK gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of KHK gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing KHK from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.