{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n KIF13A is a kinesin‐3 family motor protein that plays multifaceted roles in intracellular transport by mediating the movement of diverse cargo‐containing vesicles along microtubules. Early studies demonstrated that KIF13A is a plus end–directed motor which binds the AP‐1 adaptor complex via β1‐adaptin to transport mannose‐6‐phosphate receptor–containing vesicles from the trans‐Golgi network to the plasma membrane (1). Subsequent work revealed that KIF13A also participates in cytokinesis by facilitating the translocation of FYVE‐CENT from the centrosome to the midbody, thereby ensuring proper abscission (2). In pigment cells, KIF13A partners with the clathrin adaptor AP‐1 to create peripheral recycling endosomal domains critical for targeting melanosomal enzymes to maturing melanosomes, a process that underpins proper melanosome biogenesis and pigmentation (3,4). Structural analyses have further shown that the motor’s activity depends on an interrelated tandem of domains—comprising a short neck, CC1, and an FHA domain—that assemble into a stable dimer to activate its motility (5)."}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its classical role in secretory and recycling pathways, KIF13A has been implicated in regulating cell surface receptor recycling. For instance, it can restore the trafficking of VE‐cadherin from endosomes to the plasma membrane in endothelial cells, thereby contributing to endothelial polarity and vascular stability (6). In cancer cells, a coordinated function of KIF13A with KIF3A mediates the stepwise transport of MT1‐MMP–containing vesicles from the trans‐Golgi network to endosomes and ultimately to the cell surface, which is essential for extracellular matrix degradation and invasive behavior (7). In addition, KIF13A has emerged as the first molecular motor to be linked with the transport of influenza A virus ribonucleoprotein (vRNP)–Rab11 vesicles to the plasma membrane—a crucial step in viral assembly (8). Its expression is further regulated in response to cellular reprogramming and microRNA‐mediated control, such that relief from microRNA silencing (as seen in cells undergoing epithelial‐to‐mesenchymal transition) or targeting by miR‑19b‑3p in skeletal muscle can impact KIF13A levels, thereby influencing cellular polarity and metabolic adaptations (9,10). Finally, mutations in KIF13A, including a de novo frameshift identified in a patient with clinical features of hypomelanosis of Ito, have underscored its importance in neural crest cell migration and melanosome biogenesis (11).\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies establish KIF13A as a central regulator of vesicular trafficking with pivotal roles in diverse cellular processes including receptor recycling, organelle biogenesis, cytokinesis, cancer cell invasion, and viral assembly.\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n (1)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", (2)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", (3)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", (4)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", (5)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", (6)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", (7)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", (8)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ", (9)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ", (10)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ", (11)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "T Nakagawa, M Setou, D Seog, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb2036"}], "href": "https://doi.org/10.1038/ncb2036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20208530"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20208530"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Cédric Delevoye, Ilse Hurbain, Danièle Tenza, et al. 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