KIF20B Gene

HGNC Family	Kinesins (KIF)
Name	kinesin family member 20B
Description	Enables several functions, including ATP hydrolysis activity; WW domain binding activity; and plus-end-directed microtubule motor activity. Involved in positive regulation of cell population proliferation and positive regulation of cytokinesis. Located in several cellular components, including microtubule cytoskeleton; midbody; and nuclear lumen. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n KIF20B, a member of the kinesin‐6 family, functions as a molecular motor with dual roles in both normal neural development and cancer. In the developing brain, KIF20B is critical for proper cytokinesis in polarized neuroepithelial stem cells, where it organizes midbody structure and facilitates efficient abscission, ensuring correct neural progenitor proliferation and cortical growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Moreover, in postmitotic neurons, KIF20B interacts with cargos such as Shootin1 to promote neuronal polarization, axon outgrowth, and the overall morphogenesis of cortical neurons by modulating microtubule organization and the formation of cell protrusions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In cancer, aberrant overexpression of KIF20B has been linked to enhanced cell proliferation and tumor progression. In colorectal and oral squamous cell carcinomas, for example, high levels of KIF20B are associated with activation of epithelial–mesenchymal transition (EMT), increased formation of invadopodia, and augmented cell migration and invasion, all of which contribute to a poorer prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Furthermore, regulatory mechanisms involving upstream factors such as USP7 and FBXO38 help maintain KIF20B stability during cytokinesis, and interference with these pathways not only disrupts midbody organization but also sensitizes cancer cells to microtubule-targeted agents."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings underscore the multifaceted role of KIF20B as a key mediator of cytokinesis and neuronal morphogenesis during brain development, as well as an oncogenic driver that promotes cancer cell proliferation, EMT, and invasion.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kerstin M Janisch, Vita M Vock, Michael S Fleming, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The vertebrate-specific Kinesin-6, Kif20b, is required for normal cytokinesis of polarized cortical stem cells and cerebral cortex size."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.093286"}], "href": "https://doi.org/10.1242/dev.093286"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24173802"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24173802"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kerstin M Janisch, Katrina C McNeely, Joseph M Dardick, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Kinesin-6 KIF20B is required for efficient cytokinetic furrowing and timely abscission in human cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E17-08-0495"}], "href": "https://doi.org/10.1091/mbc.E17-08-0495"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29167382"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29167382"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Tamar Sapir, Talia Levy, Akira Sakakibara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Shootin1 acts in concert with KIF20B to promote polarization of migrating neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.5425-12.2013"}], "href": "https://doi.org/10.1523/JNEUROSCI.5425-12.2013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23864681"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23864681"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Katrina C McNeely, Timothy D Cupp, Jessica Neville Little, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutation of Kinesin-6 Kif20b causes defects in cortical neuron polarization and morphogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neural Dev (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13064-017-0082-5"}], "href": "https://doi.org/10.1186/s13064-017-0082-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28359322"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28359322"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Wen-Feng Lin, Xiao-Lu Lin, Seng-Wang Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pseudopod-associated protein KIF20B promotes Gli1-induced epithelial-mesenchymal transition modulated by pseudopodial actin dynamic in human colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Carcinog (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mc.22812"}], "href": "https://doi.org/10.1002/mc.22812"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29573464"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29573464"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Zhang-Yi Li, Zhi-Xing Wang, Chang-Chun Li "}, {"type": "b", "children": [{"type": "t", "text": "Kinesin family member 20B regulates tongue cancer progression by promoting cell proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2019.9851"}], "href": "https://doi.org/10.3892/mmr.2019.9851"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30664160"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30664160"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Anna Georges, Etienne Coyaud, Edyta Marcon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "USP7 Regulates Cytokinesis through FBXO38 and KIF20B."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-39368-y"}], "href": "https://doi.org/10.1038/s41598-019-39368-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30804394"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30804394"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Xinran Liu, Yangkai Li, Xia Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of kinesin family member 20B sensitizes hepatocellular carcinoma cell to microtubule-targeting agents by blocking cytokinesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.13794"}], "href": "https://doi.org/10.1111/cas.13794"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30191636"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30191636"}]}]}]}
Synonyms	MPHOSPH1, MPP-1, CT90, MPP1, KRMP1
Proteins	KI20B_HUMAN
NCBI Gene ID	9585
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

KIF20B has 7,936 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 118 datasets.

Click the + buttons to view associations for KIF20B from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

KIF20B Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KIF20B gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of KIF20B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of KIF20B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KIF20B gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of KIF20B gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of KIF20B gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of KIF20B gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of KIF20B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of KIF20B gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with KIF20B protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with KIF20B gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of KIF20B gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of KIF20B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of KIF20B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of KIF20B gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing KIF20B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing KIF20B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing KIF20B protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing KIF20B protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with KIF20B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with KIF20B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of KIF20B gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with KIF20B gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with KIF20B gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with KIF20B gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of KIF20B protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by KIF20B gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving KIF20B gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with KIF20B gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with KIF20B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with KIF20B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with KIF20B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with KIF20B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at KIF20B gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of KIF20B gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of KIF20B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing KIF20B from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of KIF20B gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with KIF20B gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing KIF20B from the GeneSigDB Published Gene Signatures dataset.