KIF3B Gene

HGNC Family	Kinesins (KIF)
Name	kinesin family member 3B
Description	The protein encoded by this gene acts as a heterodimer with kinesin family member 3A to aid in chromosome movement during mitosis and meiosis. The encoded protein is a plus end-directed microtubule motor and can interact with the SMC3 subunit of the cohesin complex. In addition, the encoded protein may be involved in the intracellular movement of membranous organelles. This protein and kinesin family member 3A form the kinesin II subfamily of the kinesin superfamily. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n KIF3B, an essential subunit of the heterotrimeric kinesin‐2 complex, plays multifaceted roles in intracellular cargo transport that are critical for normal cellular homeostasis and development as well as in disease. For example, in epithelial cells KIF3B cooperates with KIF3A to transport key regulatory complexes—including adenomatous polyposis coli (APC) and beta‐catenin—to membrane protrusions, thereby influencing cell migration and apical–basal polarity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In renal epithelia, KIF3B mediates the assembly of a polycystin‐2 (PC2)–fibrocystin (FPC) complex that is required for proper channel regulation, and it links the chloride transporter CLC‐5 to microtubule‐based endocytic trafficking, ensuring efficient receptor recycling and endocytosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " During cell division, the kinesin‐2 complex containing KIF3B is recruited to the mitotic apparatus where its interaction with proteins such as Syne‐1 is necessary for the proper accumulation of membrane vesicles at the spindle midbody. Disruption of KIF3B function in this context leads to spindle defects, aneuploidy, and cytokinesis failure."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In addition, aberrant expression or structural rearrangements involving KIF3B have been implicated in oncogenesis; over‐expression of KIF3B correlates with enhanced proliferation and poor survival in hepatocellular carcinoma, and fusion events incorporating KIF3B with the transcriptional regulator PAX5 have been observed in acute lymphoblastic leukemia, suggesting that its deregulation may contribute to tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Emerging evidence also hints at a role for KIF3B in neuronal transport by supporting the trafficking of vesicles that contain NMDA receptor subunits and components of the APC complex, thereby potentially impacting synaptic function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Collectively, these studies illustrate that KIF3B is a versatile motor protein subunit integral to the transport of diverse molecular cargos, with significant implications for cell polarity, division, signal transduction, and disease pathogenesis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Takeshi Jimbo, Yoshihiro Kawasaki, Ryo Koyama, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a link between the tumour suppressor APC and the kinesin superfamily."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb779"}], "href": "https://doi.org/10.1038/ncb779"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11912492"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11912492"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Nan Gao, Klaus H Kaestner "}, {"type": "b", "children": [{"type": "t", "text": "Cdx2 regulates endo-lysosomal function and epithelial cell polarity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.1921510"}], "href": "https://doi.org/10.1101/gad.1921510"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20551175"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20551175"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yuliang Wu, Xiao-Qing Dai, Qiang Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Kinesin-2 mediates physical and functional interactions between polycystin-2 and fibrocystin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddl404"}], "href": "https://doi.org/10.1093/hmg/ddl404"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17008358"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17008358"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Anita A C Reed, Nellie Y Loh, Sara Terryn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CLC-5 and KIF3B interact to facilitate CLC-5 plasma membrane expression, endocytosis, and microtubular transport: relevance to pathophysiology of Dent's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Renal Physiol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajprenal.00038.2009"}], "href": "https://doi.org/10.1152/ajprenal.00038.2009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19940036"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19940036"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jun Fan, Kenneth A Beck "}, {"type": "b", "children": [{"type": "t", "text": "A role for the spectrin superfamily member Syne-1 and kinesin II in cytokinesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.00892"}], "href": "https://doi.org/10.1242/jcs.00892"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14709720"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14709720"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Keiko Haraguchi, Tomoatsu Hayashi, Takeshi Jimbo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of the kinesin-2 family protein, KIF3, during mitosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M507028200"}], "href": "https://doi.org/10.1074/jbc.M507028200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16298999"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16298999"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Xiaodong Huang, Fang Liu, Changlai Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Suppression of KIF3B expression inhibits human hepatocellular carcinoma proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dig Dis Sci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10620-013-2969-2"}], "href": "https://doi.org/10.1007/s10620-013-2969-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24368420"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24368420"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Qian An, Sarah L Wright, Zoë J Konn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Variable breakpoints target PAX5 in patients with dicentric chromosomes: a model for the basis of unbalanced translocations in cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0803494105"}], "href": "https://doi.org/10.1073/pnas.0803494105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18957548"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18957548"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Ashwaq Hassan Alsabban, Momo Morikawa, Yosuke Tanaka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Kinesin Kif3b mutation reduces NMDAR subunit NR2A trafficking and causes schizophrenia-like phenotypes in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embj.2018101090"}], "href": "https://doi.org/10.15252/embj.2018101090"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31746486"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31746486"}]}]}]}
Synonyms	KLP-11, HH0048, FLA8
Proteins	KIF3B_HUMAN
NCBI Gene ID	9371
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

KIF3B has 6,181 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 114 datasets.

Click the + buttons to view associations for KIF3B from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

KIF3B Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KIF3B gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of KIF3B gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of KIF3B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of KIF3B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KIF3B gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of KIF3B gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of KIF3B gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of KIF3B gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of KIF3B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of KIF3B gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with KIF3B protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of KIF3B gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of KIF3B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of KIF3B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of KIF3B gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing KIF3B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing KIF3B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing KIF3B protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing KIF3B protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with KIF3B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with KIF3B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing KIF3B protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of KIF3B gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with KIF3B gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with KIF3B gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with KIF3B gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of KIF3B protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by KIF3B gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving KIF3B gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with KIF3B gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with KIF3B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with KIF3B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with KIF3B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with KIF3B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at KIF3B gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of KIF3B gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of KIF3B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing KIF3B from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of KIF3B gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with KIF3B gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.