KLF2 Gene

HGNC Family	Zinc fingers
Name	Kruppel-like factor 2
Description	This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is expressed early in mammalian development and is found in many different cell types. The protein acts to bind the CACCC box found in the promoter of target genes to activate their transcription. It plays a role in many processes during development and disease including adipogenesis, embryonic erythropoiesis, epithelial integrity, inflammation and t-cell viability. [provided by RefSeq, Mar 2017]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Krüppel‐like factor 2 (KLF2) is emerging as a pivotal transcriptional regulator that integrates biomechanical and pharmacological signals to maintain vascular and cellular homeostasis across diverse biological systems. In endothelial cells, KLF2 is robustly induced by atheroprotective laminar shear stress and by statins, triggering a gene program that enhances expression of endothelial nitric oxide synthase and thrombomodulin while suppressing proinflammatory adhesion molecules and tissue factor; these actions collectively promote antithrombotic and anti‐inflammatory endothelial phenotypes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n Moreover, KLF2 directly upregulates the miR‐143/145 cluster, thereby mediating intercellular communication via extracellular vesicles that modulate vascular smooth muscle cell phenotype and reduce atherosclerotic lesion formation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the context of cancer, however, exosomes carrying miR‐25‐3p from colorectal tumor cells can suppress KLF2 (and its homologue KLF4) in endothelial cells, thereby promoting vascular permeability, angiogenesis, and metastatic dissemination."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Outside of the vasculature, KLF2 functions as a critical component of the pluripotency network in embryonic stem cells, where it collaborates with other KLF family members to sustain self‐renewal."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In T lymphocytes, KLF2 is indispensable for proper trafficking; by regulating the expression of receptors such as sphingosine‐1‐phosphate receptor 1 (S1P1), it orchestrates thymic egress and peripheral recirculation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Additionally, in monocytes, KLF2 acts as a negative regulator of proinflammatory activation, with reduced KLF2 levels correlating with enhanced inflammatory responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n KLF2 also plays a role in adipose tissue biology by negatively regulating adipocyte differentiation through suppression of key adipogenic transcription factors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " Fine-tuning of endothelial KLF2 expression is further achieved by microRNA-mediated mechanisms; miR-92a, for example, directly targets the 3′ untranslated region of KLF2 mRNA, thereby modulating endothelial activation and vascular function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "15"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings underscore KLF2’s central role as a molecular switch—integrating signals from shear stress, pharmacologic agents, and microRNAs—to coordinate endothelial quiescence, regulate immune cell trafficking, and influence cellular differentiation. Its diverse functions are instrumental in maintaining vascular integrity, modulating inflammatory responses, and preserving stem cell pluripotency, thereby highlighting KLF2 as a promising target for therapeutic modulation in cardiovascular disease, cancer, and immune dysfunction."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Eduard Hergenreider, Susanne Heydt, Karine Tréguer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb2441"}], "href": "https://doi.org/10.1038/ncb2441"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22327366"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22327366"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Sucharita SenBanerjee, Zhiyong Lin, G Brandon Atkins, et al. "}, {"type": "b", "children": [{"type": "t", "text": "KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20031132"}], "href": "https://doi.org/10.1084/jem.20031132"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15136591"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15136591"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Rob J Dekker, Simone van Soest, Ruud D Fontijn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prolonged fluid shear stress induces a distinct set of endothelial cell genes, most specifically lung Krüppel-like factor (KLF2)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2002-01-0046"}], "href": "https://doi.org/10.1182/blood-2002-01-0046"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12176889"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12176889"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Sucharita Sen-Banerjee, Samy Mir, Zhiyong Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Kruppel-like factor 2 as a novel mediator of statin effects in endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circulation (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCULATIONAHA.104.525774"}], "href": "https://doi.org/10.1161/CIRCULATIONAHA.104.525774"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16043642"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16043642"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Zhiyong Lin, Ajay Kumar, Sucharita SenBanerjee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Kruppel-like factor 2 (KLF2) regulates endothelial thrombotic function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.RES.0000159707.05637.a1"}], "href": "https://doi.org/10.1161/01.RES.0000159707.05637.a1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15718498"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15718498"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Rob J Dekker, Reinier A Boon, Mariska G Rondaij, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-018-07810-w"}], "href": "https://doi.org/10.1038/s41467-018-07810-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30568162"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30568162"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jianming Jiang, Yun-Shen Chan, Yuin-Han Loh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A core Klf circuitry regulates self-renewal of embryonic stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1698"}], "href": "https://doi.org/10.1038/ncb1698"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18264089"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18264089"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Corey M Carlson, Bart T Endrizzi, Jinghai Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Kruppel-like factor 2 regulates thymocyte and T-cell migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature04882"}], "href": "https://doi.org/10.1038/nature04882"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16855590"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16855590"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yann M Kerdiles, Daniel R Beisner, Roberto Tinoco, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ni.1689"}], "href": "https://doi.org/10.1038/ni.1689"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19136962"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19136962"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Hiranmoy Das, Ajay Kumar, Zhiyong Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Kruppel-like factor 2 (KLF2) regulates proinflammatory activation of monocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0508235103"}], "href": "https://doi.org/10.1073/pnas.0508235103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16617118"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16617118"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Sucharita Sen Banerjee, Mark W Feinberg, Masafumi Watanabe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Krüppel-like factor KLF2 inhibits peroxisome proliferator-activated receptor-gamma expression and adipogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M210859200"}], "href": "https://doi.org/10.1074/jbc.M210859200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12426306"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12426306"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yun Fang, Peter F Davies "}, {"type": "b", "children": [{"type": "t", "text": "Site-specific microRNA-92a regulation of Kruppel-like factors 4 and 2 in atherosusceptible endothelium."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/ATVBAHA.111.244053"}], "href": "https://doi.org/10.1161/ATVBAHA.111.244053"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22267480"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22267480"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Xavier Loyer, Stéphane Potteaux, Anne-Clémence Vion, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of microRNA-92a prevents endothelial dysfunction and atherosclerosis in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.114.302213"}], "href": "https://doi.org/10.1161/CIRCRESAHA.114.302213"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24255059"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24255059"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Wei Wu, Han Xiao, Andrés Laguna-Fernandez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Flow-Dependent Regulation of Kruppel-Like Factor 2 Is Mediated by MicroRNA-92a."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circulation (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCULATIONAHA.110.005108"}], "href": "https://doi.org/10.1161/CIRCULATIONAHA.110.005108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21768538"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21768538"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Kush M Parmar, H Benjamin Larman, Guohao Dai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI24787"}], "href": "https://doi.org/10.1172/JCI24787"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16341264"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16341264"}]}]}]}
Synonyms	LKLF
Proteins	KLF2_HUMAN
NCBI Gene ID	10365
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

KLF2 has 10,791 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 114 datasets.

Click the + buttons to view associations for KLF2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

KLF2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KLF2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of KLF2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of KLF2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of KLF2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of KLF2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KLF2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of KLF2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of KLF2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of KLF2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of KLF2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of KLF2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of KLF2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with KLF2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of KLF2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of KLF2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of KLF2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of KLF2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing KLF2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing KLF2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with KLF2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with KLF2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of KLF2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with KLF2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with KLF2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with KLF2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of KLF2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by KLF2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with KLF2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with KLF2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with KLF2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with KLF2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with KLF2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at KLF2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of KLF2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of KLF2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing KLF2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with KLF2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with KLF2 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of KLF2 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with KLF2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.