KLHL29 Gene

HGNC Family	BTB (POZ) domain containing (BTBD), Kelch-like (KLHL)
Name	kelch-like family member 29
Description	Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have implicated the Kelch‐like family member 29 (KLHL29) gene in a variety of biological processes and disease contexts. In one population‐genetics study of north‐eastern Brazilians, a highly differentiated single nucleotide polymorphism near KLHL29 was identified in the Amerindian branch, suggesting that this gene may have been subject to evolutionary selection possibly related to immune, metabolic, or developmental functions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In colon epithelia, a novel fusion transcript—NR5A2–KLHL29FT—resulting from a polymorphic germline insertion into the KLHL29 locus was discovered; notably, the reduced expression of this transcript in colon cancers points toward a potential role in tumor onset or progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In studies of doxorubicin‐induced cardiotoxicity, KLHL29 expression was significantly decreased at both the mRNA and protein levels in rat hearts, indicating that it may serve as a marker or mediator of anthracycline-associated cardiac damage."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In livestock research, positional candidate analyses have mapped KLHL29 to quantitative trait loci affecting milking speed in dairy cows, suggesting a contribution to muscle or cellular functions underlying this trait."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Epigenome-wide association studies in a Mexican American cohort revealed differential DNA methylation at CpG sites annotated to KLHL29 in individuals with mild cognitive impairment, implying possible involvement in neural or metabolic pathways linked to cognitive aging."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In osteoarthritis research, experiments in synoviocytes demonstrated that KLHL29 is a direct target of miR-92a-3p, which may contribute to inflammatory regulation and joint homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Moreover, genome-wide association analyses in Chinese tongue sole associated KLHL29 with female-biased sexual size dimorphism, while studies in catfish identified this gene among those involved in the ubiquitination pathway contributing to heat stress response, highlighting roles in developmental regulation and protein degradation under stress conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings support a multifaceted function for KLHL29 as a component of the Kelch-like gene family engaged in the ubiquitin-proteasome pathway, with broader implications in evolutionary adaptation, tissue homeostasis, stress response, and disease pathogenesis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Josyf C Mychaleckyj, Alexandre Havt, Uma Nayak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-Wide Analysis in Brazilians Reveals Highly Differentiated Native American Genome Regions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Evol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/molbev/msw249"}], "href": "https://doi.org/10.1093/molbev/msw249"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28100790"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28100790"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhenguo Sun, Xiquan Ke, Steven L Salzberg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The novel fusion transcript NR5A2-KLHL29FT is generated by an insertion at the KLHL29 locus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cncr.30510"}], "href": "https://doi.org/10.1002/cncr.30510"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28081303"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28081303"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Kendra K S Nordgren, Marshall Hampton, Kendall B Wallace "}, {"type": "b", "children": [{"type": "t", "text": "Editor's Highlight: The Altered DNA Methylome of Chronic Doxorubicin Exposure in Sprague Dawley Rats."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Toxicol Sci (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/toxsci/kfx150"}], "href": "https://doi.org/10.1093/toxsci/kfx150"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28962528"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28962528"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Andrew Marete, Goutam Sahana, Sébastien Fritz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study for milking speed in French Holstein cows."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Dairy Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3168/jds.2017-14067"}], "href": "https://doi.org/10.3168/jds.2017-14067"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29705414"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29705414"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Gita A Pathak, Talisa K Silzer, Jie Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-Wide Methylation of Mild Cognitive Impairment in Mexican Americans Highlights Genes Involved in Synaptic Transport, Alzheimer's Disease-Precursor Phenotypes, and Metabolic Morbidities."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Alzheimers Dis (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/JAD-190634"}], "href": "https://doi.org/10.3233/JAD-190634"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31640099"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31640099"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Zongting Shi, Jun He, Jian He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Micro-fragmented adipose tissue regulated the biological functions of osteoarthritis synoviocytes by upregulating MiR-92a-3p expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tissue Cell (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.tice.2021.101716"}], "href": "https://doi.org/10.1016/j.tice.2021.101716"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34979377"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34979377"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Na Wang, Jin Gao, Yang Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of crucial factors involved in Cynoglossus semilaevis sexual size dimorphism by GWAS and demonstration of zbed1 regulatory network by DAP-seq."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genomics (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ygeno.2022.110376"}], "href": "https://doi.org/10.1016/j.ygeno.2022.110376"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35513290"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35513290"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Y Jin, T Zhou, X Geng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A genome-wide association study of heat stress-associated SNPs in catfish."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anim Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/age.12482"}], "href": "https://doi.org/10.1111/age.12482"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27476875"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27476875"}]}]}]}
Synonyms	KBTBD9
Proteins	KLH29_HUMAN
NCBI Gene ID	114818
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

KLHL29 has 5,533 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 104 datasets.

Click the + buttons to view associations for KLHL29 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

KLHL29 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KLHL29 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of KLHL29 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of KLHL29 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of KLHL29 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of KLHL29 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KLHL29 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of KLHL29 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of KLHL29 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of KLHL29 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of KLHL29 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of KLHL29 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of KLHL29 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of KLHL29 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of KLHL29 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of KLHL29 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of KLHL29 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing KLHL29 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of KLHL29 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing KLHL29 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with KLHL29 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of KLHL29 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with KLHL29 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with KLHL29 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with KLHL29 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with KLHL29 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of KLHL29 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by KLHL29 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with KLHL29 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with KLHL29 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with KLHL29 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with KLHL29 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with KLHL29 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with KLHL29 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at KLHL29 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of KLHL29 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of KLHL29 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing KLHL29 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with KLHL29 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of KLHL29 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing KLHL29 from the GeneSigDB Published Gene Signatures dataset.