KLK6 Gene

HGNC Family	Kallikreins (KLK), Proteases, serine (PRSS)
Name	kallikrein-related peptidase 6
Description	This gene encodes a member of the kallikrein subfamily of the peptidase S1 family of serine proteases. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The encoded preproprotein is proteolytically processed to generate the mature protease. Expression of this protease is regulated by steroid hormones and may be elevated in multiple human cancers and in serum from psoriasis patients. The encoded protease may participate in the cleavage of amyloid precursor protein and alpha-synuclein, thus implicating this protease in Alzheimer's and Parkinson's disease, respectively. This gene is located in a gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Human kallikrein‐related peptidase 6 (KLK6) is a trypsin‐like serine protease with multifaceted functions that span several organ systems and disease contexts. In cancer, its elevated expression in ovarian carcinomas has been exploited as a potential diagnostic marker, whereas in colorectal cancer, high KLK6 mRNA levels correlate with advanced local invasion, metastasis, and poor prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In contrast, studies in breast cancer have revealed that epigenetic silencing of KLK6 contributes to a more malignant, invasive phenotype through deregulation of epithelial-to-mesenchymal transition, supporting a tumor-suppressive role when functional KLK6 is expressed."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the skin, KLK6 is one of several kallikreins that participate in epidermal desquamation by cleaving intercellular adhesion molecules such as desmoglein 1; its proteolytic activity is tightly regulated by serine protease inhibitors (SPIs) such as LEKTI, ensuring the controlled turnover of the stratum corneum."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the central nervous system, KLK6 – also known as neurosin – exhibits a structure and substrate specificity consistent with a degradative protease. Structural studies have provided a three-dimensional view that aligns it more closely with trypsin-like enzymes, and kinetic analyses demonstrate its ability to efficiently process extracellular matrix proteins (e.g., fibrinogen, collagens) as well as substrates implicated in neurodegeneration, such as myelin basic protein and alpha-synuclein."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings highlight the context-dependent nature of KLK6 activity. Its ability to modulate extracellular proteolytic cascades underlies its involvement in tissue remodeling, epidermal barrier homeostasis, cancer progression, and neural integrity. The dual roles observed—in some settings promoting invasion and metastasis, and in others curbing malignant progression by suppressing epithelial-to-mesenchymal transition—underscore the complexity of KLK6’s function in both normal physiology and disease."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "16"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "John B Welsh, Lisa M Sapinoso, Suzanne G Kern, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0530278100"}], "href": "https://doi.org/10.1073/pnas.0530278100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12624183"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12624183"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kazuhiko Ogawa, Tohru Utsunomiya, Koshi Mimori, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical significance of human kallikrein gene 6 messenger RNA expression in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-04-2281"}], "href": "https://doi.org/10.1158/1078-0432.CCR-04-2281"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15837738"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15837738"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Georgios Pampalakis, Evangelia Prosnikli, Theodora Agalioti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A tumor-protective role for human kallikrein-related peptidase 6 in breast cancer mediated by inhibition of epithelial-to-mesenchymal transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-08-1976"}], "href": "https://doi.org/10.1158/0008-5472.CAN-08-1976"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19383923"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19383923"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Carla A Borgoño, Iacovos P Michael, Nahoko Komatsu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A potential role for multiple tissue kallikrein serine proteases in epidermal desquamation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M607567200"}], "href": "https://doi.org/10.1074/jbc.M607567200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17158887"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17158887"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Matthew J Bernett, Sachiko I Blaber, Isobel A Scarisbrick, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Crystal structure and biochemical characterization of human kallikrein 6 reveals that a trypsin-like kallikrein is expressed in the central nervous system."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M202392200"}], "href": "https://doi.org/10.1074/jbc.M202392200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11983703"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11983703"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Angeliki Magklara, Ali A Mellati, Gregory A Wasney, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of the enzymatic activity of human kallikrein 6: Autoactivation, substrate specificity, and regulation by inhibitors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0006-291x(03)01271-3"}], "href": "https://doi.org/10.1016/s0006-291x(03"}, {"type": "t", "text": "01271-3) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12878203"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12878203"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Manik C Ghosh, Linda Grass, Antoninus Soosaipillai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human kallikrein 6 degrades extracellular matrix proteins and may enhance the metastatic potential of tumour cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000081102"}], "href": "https://doi.org/10.1159/000081102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15557757"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15557757"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Pedro Francisco Angelo, Aurelio Resende Lima, Fabiana M Alves, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Substrate specificity of human kallikrein 6: salt and glycosaminoglycan activation effects."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M510096200"}], "href": "https://doi.org/10.1074/jbc.M510096200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16321973"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16321973"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "A B Makar, K E McMartin, M Palese, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Formate assay in body fluids: application in methanol poisoning."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Med (1975)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/0006-2944(75)90147-7"}], "href": "https://doi.org/10.1016/0006-2944(75"}, {"type": "t", "text": "90147-7) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "1"}], "href": "https://pubmed.ncbi.nlm.nih.gov/1"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "K S Bose, R H Sarma "}, {"type": "b", "children": [{"type": "t", "text": "Delineation of the intimate details of the backbone conformation of pyridine nucleotide coenzymes in aqueous solution."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (1975)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/0006-291x(75)90482-9"}], "href": "https://doi.org/10.1016/0006-291x(75"}, {"type": "t", "text": "90482-9) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "2"}], "href": "https://pubmed.ncbi.nlm.nih.gov/2"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "R J Smith, R G Bryant "}, {"type": "b", "children": [{"type": "t", "text": "Metal substitutions incarbonic anhydrase: a halide ion probe study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (1975)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/0006-291x(75)90498-2"}], "href": "https://doi.org/10.1016/0006-291x(75"}, {"type": "t", "text": "90498-2) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "3"}], "href": "https://pubmed.ncbi.nlm.nih.gov/3"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "U N Wiesmann, S DiDonato, N N Herschkowitz "}, {"type": "b", "children": [{"type": "t", "text": "Effect of chloroquine on cultured fibroblasts: release of lysosomal hydrolases and inhibition of their uptake."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (1975)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/0006-291x(75)90506-9"}], "href": "https://doi.org/10.1016/0006-291x(75"}, {"type": "t", "text": "90506-9) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "4"}], "href": "https://pubmed.ncbi.nlm.nih.gov/4"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "W A Hendrickson, K B Ward "}, {"type": "b", "children": [{"type": "t", "text": "Atomic models for the polypeptide backbones of myohemerythrin and hemerythrin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (1975)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/0006-291x(75)90508-2"}], "href": "https://doi.org/10.1016/0006-291x(75"}, {"type": "t", "text": "90508-2) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "5"}], "href": "https://pubmed.ncbi.nlm.nih.gov/5"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Y W Chow, R Pietranico, A Mukerji "}, {"type": "b", "children": [{"type": "t", "text": "Studies of oxygen binding energy to hemoglobin molecule."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (1975)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/0006-291x(75)90518-5"}], "href": "https://doi.org/10.1016/0006-291x(75"}, {"type": "t", "text": "90518-5) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "6"}], "href": "https://pubmed.ncbi.nlm.nih.gov/6"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "T R Anderson, T A Slotkin "}, {"type": "b", "children": [{"type": "t", "text": "Maturation of the adrenal medulla--IV. Effects of morphine."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Pharmacol (1975)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/0006-2952(75)90020-9"}], "href": "https://doi.org/10.1016/0006-2952(75"}, {"type": "t", "text": "90020-9) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "7"}], "href": "https://pubmed.ncbi.nlm.nih.gov/7"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "K Moroi, T Sato "}, {"type": "b", "children": [{"type": "t", "text": "Comparison between procaine and isocarboxazid metabolism in vitro by a liver microsomal amidase-esterase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Pharmacol (1975)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/0006-2952(75)90029-5"}], "href": "https://doi.org/10.1016/0006-2952(75"}, {"type": "t", "text": "90029-5) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "8"}], "href": "https://pubmed.ncbi.nlm.nih.gov/8"}]}]}]}
Synonyms	BSSP, PRSS18, Klk7, SP59, HK6, PRSS9
Proteins	KLK6_HUMAN
NCBI Gene ID	5653
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

KLK6 has 6,410 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 110 datasets.

Click the + buttons to view associations for KLK6 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

KLK6 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KLK6 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of KLK6 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of KLK6 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KLK6 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of KLK6 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of KLK6 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of KLK6 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of KLK6 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of KLK6 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with KLK6 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with KLK6 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of KLK6 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of KLK6 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of KLK6 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing KLK6 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of KLK6 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing KLK6 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing KLK6 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing KLK6 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with KLK6 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with KLK6 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of KLK6 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with KLK6 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with KLK6 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with KLK6 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of KLK6 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by KLK6 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with KLK6 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with KLK6 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with KLK6 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with KLK6 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with KLK6 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for KLK6 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at KLK6 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of KLK6 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of KLK6 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing KLK6 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with KLK6 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with KLK6 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of KLK6 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.