KNTC1 Gene

Name	kinetochore associated 1
Description	This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. Experimental evidence indicated that the encoded protein functioned in a similar manner to that of the Drosophila rough deal protein. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n KNTC1, which encodes a kinetochore‐associated protein, is critical for proper chromosome segregation during mitosis and for sustaining an effective mitotic checkpoint. Its normal function ensures accurate spindle attachment and maintenance of genomic stability, while dysregulation of KNTC1 has been implicated in diverse disease contexts. For instance, in esophageal squamous cell carcinoma, high KNTC1 expression is linked to enhanced cell viability and reduced apoptosis, with knockdown studies demonstrating diminished proliferation and tumorigenesis—effects associated with alterations in mitotic spindle dynamics and hypoxia‐related pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In oral squamous cell carcinoma, reduced transcriptional activity of KNTC1 in larger tumors suggests its involvement in tumor molecular evolution."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In addition, integrative bioinformatics analyses in hepatocellular carcinoma and nasopharyngeal carcinoma have identified KNTC1 as a central hub gene in cell cycle regulation, with its aberrant expression correlating with poor prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In cervical cancer, KNTC1 overexpression is associated with higher pathological grade and inferior overall survival, and its suppression results in decreased proliferation, migration, and an increase in apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Furthermore, analysis of competing endogenous RNA networks in prostate cancer bone metastasis has revealed KNTC1 as a key node regulated by specific long non-coding RNAs, with its dysregulation being linked to adverse clinical outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Beyond oncologic settings, integrated studies in polycystic ovary syndrome have also identified KNTC1 among top hub genes, underscoring its broader role in cell cycle control in both malignant and non-malignant conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings underscore that KNTC1 not only orchestrates the fidelity of mitosis but also contributes to tumor progression and potentially chemoresistance when its expression is altered. Its recurrent identification as a core gene in various cancers and other disorders suggests that KNTC1 may represent a promising therapeutic target for modulating aberrant cell proliferation and improving clinical outcomes.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sara Ashfaq, Ahmed Siddiqui, Waqas Shafiq, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Rare Presentation of Disorder of Sex Development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cureus (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7759/cureus.12782"}], "href": "https://doi.org/10.7759/cureus.12782"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33628654"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33628654"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Marina Gonçalves Diniz, Jeane de Fatima Correia Silva, Fabricio Tinôco Alvim de Souza, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association between cell cycle gene transcription and tumor size in oral squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-015-3735-1"}], "href": "https://doi.org/10.1007/s13277-015-3735-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26152289"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26152289"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Shu Shen, Junjie Kong, Yiwen Qiu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of core genes and outcomes in hepatocellular carcinoma by bioinformatics analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.28290"}], "href": "https://doi.org/10.1002/jcb.28290"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30525236"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30525236"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Kang Liu, Min Kang, Ziyan Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bioinformatics analysis identifies hub genes and pathways in nasopharyngeal carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Lett (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ol.2019.10707"}], "href": "https://doi.org/10.3892/ol.2019.10707"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31516577"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31516577"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hui-Zhu Qiu, Ji Huang, Cheng-Cheng Xiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Screening and Discovery of New Potential Biomarkers and Small Molecule Drugs for Cervical Cancer: A Bioinformatics Analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Technol Cancer Res Treat (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1533033820980112"}], "href": "https://doi.org/10.1177/1533033820980112"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33302814"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33302814"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yanfang Chen, Zheng Chen, Jian Mo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of HCG18 and MCM3AP-AS1 That Associate With Bone Metastasis, Poor Prognosis and Increased Abundance of M2 Macrophage Infiltration in Prostate Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Technol Cancer Res Treat (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1533033821990064"}], "href": "https://doi.org/10.1177/1533033821990064"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33596783"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33596783"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Praveenkumar Devarbhavi, Lata Telang, Basavaraj Vastrad, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of key pathways and genes in polycystic ovary syndrome via integrated bioinformatics analysis and prediction of small therapeutic molecules."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Biol Endocrinol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12958-021-00706-3"}], "href": "https://doi.org/10.1186/s12958-021-00706-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33622336"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33622336"}]}]}]}
Synonyms	ROD
Proteins	KNTC1_HUMAN
NCBI Gene ID	9735
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

KNTC1 has 7,944 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 123 datasets.

Click the + buttons to view associations for KNTC1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

KNTC1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KNTC1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of KNTC1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of KNTC1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of KNTC1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of KNTC1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KNTC1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of KNTC1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of KNTC1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of KNTC1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of KNTC1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of KNTC1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of KNTC1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with KNTC1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with KNTC1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of KNTC1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of KNTC1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of KNTC1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of KNTC1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing KNTC1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of KNTC1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing KNTC1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing KNTC1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing KNTC1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing KNTC1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with KNTC1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with KNTC1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of KNTC1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with KNTC1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with KNTC1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of KNTC1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by KNTC1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DGIdb Drug Targets 2026	interacting drugs for KNTC1 protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with KNTC1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with KNTC1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with KNTC1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with KNTC1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with KNTC1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at KNTC1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of KNTC1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of KNTC1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.