KPNA3 Gene

HGNC Family	Armadillo repeat containing (ARMC), Importins (IPO)
Name	karyopherin alpha 3 (importin alpha 4)
Description	The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. [provided by RefSeq, Jan 2009]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Karyopherin‐α3 (KPNA3) functions as a key nuclear import adaptor that recognizes and binds classical nuclear localization signals (NLS) on a variety of cargo proteins involved in inflammatory, transcriptional, and oncogenic signaling. For example, KPNA3 is essential for the nuclear translocation of NF‐κB subunits in vascular endothelial cells, where its inhibition via microRNAs such as miR‐181b leads to reduced NF‐κB activity and attenuation of atherosclerotic lesion formation (1,2). In parallel, KPNA3 expression is transcriptionally activated in certain cancers; in colorectal cancer, a long noncoding RNA (DLEU1) recruits the chromatin remodeler SMARCA1 to the KPNA3 promoter, enhancing its expression and contributing to tumor progression and poorer patient prognosis (3). Moreover, regulation of cargo–KPNA3 interactions is modulated by post‐translational modifications. In the case of the transcriptional repressor capicúa, for instance, ERK‐mediated phosphorylation events inhibit binding of its C‐terminal NLS to KPNA3, thereby affecting its nuclear import and downstream gene regulatory functions (4). In inflammatory conditions, microRNAs (miR‐26a and miR‐26b) suppress KPNA3 expression in chondrocytes, which in turn enhances cytoplasmic retention of NF‐κB p65 and elevates expression of proinflammatory mediators implicated in osteoarthritis pathogenesis (5). Finally, KPNA3 also engages in the nuclear import of other regulatory factors such as MeCP2, and competition for KPNA3 binding (for example, by overexpressed TDP‐43) can attenuate p65 nuclear entry, highlighting its broader role in controlling nuclear signaling thresholds (6,7). Together, these studies underscore KPNA3’s central role as a mediator of nuclear protein import, with its expression and activity having profound implications for inflammation, cancer progression, and other disease processes."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xinghui Sun, Shaolin He, A K M Wara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Systemic delivery of microRNA-181b inhibits nuclear factor-κB activation, vascular inflammation, and atherosclerosis in apolipoprotein E-deficient mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.113.302089"}], "href": "https://doi.org/10.1161/CIRCRESAHA.113.302089"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24084690"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24084690"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Riku Fagerlund, Leena Kinnunen, Matthias Köhler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NF-{kappa}B is transported into the nucleus by importin {alpha}3 and importin {alpha}4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M500814200"}], "href": "https://doi.org/10.1074/jbc.M500814200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15677444"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15677444"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Tianyou Liu, Zhiyang Han, Huanyu Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA DLEU1 contributes to colorectal cancer progression via activation of KPNA3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12943-018-0873-2"}], "href": "https://doi.org/10.1186/s12943-018-0873-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30098595"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30098595"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Kumara Dissanayake, Rachel Toth, Jamie Blakey, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ERK/p90(RSK)/14-3-3 signalling has an impact on expression of PEA3 Ets transcription factors via the transcriptional repressor capicúa."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20101562"}], "href": "https://doi.org/10.1042/BJ20101562"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21087211"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21087211"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Anna Malinová, Zuzana Cvačková, Daniel Matějů, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201701165"}], "href": "https://doi.org/10.1083/jcb.201701165"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28515276"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28515276"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Matthew J Lyst, Robert Ekiert, Jacky Guy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Affinity for DNA Contributes to NLS Independent Nuclear Localization of MeCP2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2018.07.099"}], "href": "https://doi.org/10.1016/j.celrep.2018.07.099"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30157418"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30157418"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jingyan Zhu, Max S Cynader, William Jia "}, {"type": "b", "children": [{"type": "t", "text": "TDP-43 Inhibits NF-κB Activity by Blocking p65 Nuclear Translocation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0142296"}], "href": "https://doi.org/10.1371/journal.pone.0142296"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26571498"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26571498"}]}]}]}
Synonyms	SRP1GAMMA, HSRP1, SRP4, IPOA4
Proteins	IMA4_HUMAN
NCBI Gene ID	3839
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

KPNA3 has 6,504 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 127 datasets.

Click the + buttons to view associations for KPNA3 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

KPNA3 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by KPNA3 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KPNA3 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of KPNA3 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of KPNA3 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of KPNA3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of KPNA3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of KPNA3 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of KPNA3 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of KPNA3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of KPNA3 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of KPNA3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of KPNA3 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with KPNA3 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of KPNA3 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of KPNA3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of KPNA3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing KPNA3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing KPNA3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing KPNA3 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with KPNA3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with KPNA3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing KPNA3 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of KPNA3 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with KPNA3 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with KPNA3 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with KPNA3 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with KPNA3 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by KPNA3 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving KPNA3 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with KPNA3 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with KPNA3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with KPNA3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with KPNA3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with KPNA3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at KPNA3 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of KPNA3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of KPNA3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing KPNA3 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with KPNA3 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with KPNA3 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.