{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n KRBOX1, a gene containing a KRAB domain, appears to be a potential biomarker implicated in diverse pathological conditions. In one study of locally advanced rectal cancer, KRBOX1 was identified—among a panel of eight genes showing >16‐fold differential expression—as a candidate marker that distinguished responders from nonresponders to preoperative chemoradiation therapy (CRT)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although subsequent functional experiments in colorectal cancer cells focused on other genes (such as PSMB8), the initial discovery of marked changes in KRBOX1 expression suggests that it may contribute, directly or indirectly, to the cellular responses governing radio–sensitivity.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In a separate investigation of placental gene expression in the context of severe early–onset preeclampsia with intrauterine growth restriction, KRBOX1 was among a set of ten genes displaying a ≥±1–fold difference compared to controls."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " This differential expression pattern implicates KRBOX1 in the altered inflammatory and vascular pathways that characterize the severe form of the disorder.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Although an additional study examining lung epithelial cell transformation induced by hexavalent chromium did not directly address KRBOX1"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", the broader analyses of gene expression in these contexts underscore the importance of transcriptional regulators in mediating complex disease phenotypes. Collectively, these findings nominate KRBOX1 as an intriguing candidate for future research aimed at elucidating its mechanistic role in both cancer therapy responsiveness and placental pathology.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ye Jin Ha, Ka Hee Tak, Chan Wook Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PSMB8 as a Candidate Marker of Responsiveness to Preoperative Radiation Therapy in Rectal Cancer Patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Radiat Oncol Biol Phys (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ijrobp.2017.03.023"}], "href": "https://doi.org/10.1016/j.ijrobp.2017.03.023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28721901"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28721901"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jaana Nevalainen, Sini Skarp, Eeva-Riitta Savolainen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Intrauterine growth restriction and placental gene expression in severe preeclampsia, comparing early-onset and late-onset forms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Perinat Med (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1515/jpm-2016-0406"}], "href": "https://doi.org/10.1515/jpm-2016-0406"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28593875"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28593875"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Soyoung Park, Xiaowen Zhang, Cen Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Single-cell RNA sequencing reveals an altered gene expression pattern as a result of CRISPR/cas9-mediated deletion of Gene 33/Mig6 and chronic exposure to hexavalent chromium in human lung epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Toxicol Appl Pharmacol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.taap.2017.07.003"}], "href": "https://doi.org/10.1016/j.taap.2017.07.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28688920"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28688920"}]}]}]}