{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n KRTAP10-4 is a member of the keratin‐associated protein family, a group of genes that is canonically involved in providing rigidity and resistance to mammalian hair shafts (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " While its traditional role pertains to hair structure, a recent large‐scale genetic study in acute coronary syndrome patients identified a novel single nucleotide variant in KRTAP10-4 (rs201441480) as one of eight new genotypes associated with an increased risk of major adverse cardiovascular events."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " This unexpected association raises the possibility that genetic alterations in a gene typically linked to hair biogenesis might exert pleiotropic effects influencing cardiovascular outcomes. In addition, KRTAP10-4 has been successfully expressed using an advanced prokaryotic expression platform—one that employs a modified autoproteolytic fusion partner to produce recombinant proteins at high yields"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "—thereby providing a valuable tool for future functional investigations. Collectively, these findings suggest that while KRTAP10-4’s primary biological function is in hair shaft formation, its genetic variations may also have broader implications in human disease, which merits further research.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Dong-Dong Wu, David M Irwin, Ya-Ping Zhang "}, {"type": "b", "children": [{"type": "t", "text": "Molecular evolution of the keratin associated protein gene family in mammals, role in the evolution of mammalian hair."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Evol Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2148-8-241"}], "href": "https://doi.org/10.1186/1471-2148-8-241"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18721477"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18721477"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiaomin Liu, Hanshi Xu, Huaiqian Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "New genetic variants associated with major adverse cardiovascular events in patients with acute coronary syndromes and treated with clopidogrel and aspirin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacogenomics J (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41397-021-00245-5"}], "href": "https://doi.org/10.1038/s41397-021-00245-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34158603"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34158603"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Clemens Achmüller, Waltraud Kaar, Karin Ahrer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "N(pro) fusion technology to produce proteins with authentic N termini in E. coli."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Methods (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nmeth1116"}], "href": "https://doi.org/10.1038/nmeth1116"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18026112"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18026112"}]}]}]}