{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Although KRTAP22-2 is traditionally recognized as a keratin‐associated protein, recent systems‐level analyses of ciliary proteins have begun to reveal potential roles for such proteins in organelle biology. In one comprehensive study that used affinity proteomics, genetics, and cell biology to construct a high‐resolution network of ciliary protein interactions—including 1,319 proteins and 4,905 interactions—it is suggested that proteins like KRTAP22-2 may contribute to the dynamic regulation of ciliary structure and function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " This study linked key cellular processes such as vesicle transport, cytoskeletal organization, signaling, and ubiquitination with ciliary signaling and proteostasis. Accordingly, although the exact role of KRTAP22-2 within the cilia remains to be fully delineated, its inclusion in this network raises the possibility that it might participate in the assembly or maintenance of the ciliary structure, potentially impacting ciliogenesis and the organelle-specific regulation of protein turnover. By placing KRTAP22-2 in the context of these interactions, the study underscores how proteins traditionally associated with other cellular functions might also contribute to ciliary integrity and, by extension, to disease mechanisms associated with ciliary dysfunction.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Karsten Boldt, Jeroen van Reeuwijk, Qianhao Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An organelle-specific protein landscape identifies novel diseases and molecular mechanisms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms11491"}], "href": "https://doi.org/10.1038/ncomms11491"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27173435"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27173435"}]}]}]}