{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Keratin‐associated protein 26‐1 (KRTAP26-1) is a member of the KAP family whose proteins are known for their critical role in determining the physical properties of hair and wool fibers by cross‐linking keratin intermediate filaments. In human studies, KRTAP26-1 expression is highly tissue‐restricted – it is found exclusively in the hair follicle and, more specifically, localized in the differentiated portion of the hair cuticle, suggesting an important role in hair structure and quality."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In sheep, the ovine homologue of this gene has been associated with the physico‐mechanical properties of wool, reinforcing the notion that KRTAP26-1 contributes to fiber integrity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its role in fiber formation, KRTAP26-1 has been identified as one of several placental‐specific genes on chromosome 21. This placental expression was explored for noninvasive prenatal diagnosis purposes; however, the low abundance and quality of its cell‐free mRNA fragments in maternal plasma limited its utility as a diagnostic marker for conditions such as fetal trisomy 21."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings suggest that while KRTAP26-1 plays a well‐defined structural role in hair and wool fibers, its placental expression points to an additional, albeit less characterized, role in placental biology.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "M A Rogers, L Langbein, S Praetzel-Wunder, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization and expression analysis of the hair keratin associated protein KAP26.1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Dermatol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1365-2133.2008.08743.x"}], "href": "https://doi.org/10.1111/j.1365-2133.2008.08743.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18647308"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18647308"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Shaobin Li, Huitong Zhou, Hua Gong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of the Ovine Keratin-Associated Protein 26-1 Gene and Its Association with Variation in Wool Traits."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes (Basel) (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/genes8090225"}], "href": "https://doi.org/10.3390/genes8090225"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28902131"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28902131"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Gregory E Miller, Ann E Borders, Amy H Crockett, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Maternal socioeconomic disadvantage is associated with transcriptional indications of greater immune activation and slower tissue maturation in placental biopsies and newborn cord blood."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Behav Immun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbi.2017.04.014"}], "href": "https://doi.org/10.1016/j.bbi.2017.04.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28434870"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28434870"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Fan Zhou, Shanling Liu, He Wang "}, {"type": "b", "children": [{"type": "t", "text": "Noninvasively diagnosing for fetal trisomy 21 by examining heterozygous single nucleotide polymorphisms in the placental specific genes on chromosome 21."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Obstet Gynecol Reprod Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejogrb.2018.09.015"}], "href": "https://doi.org/10.1016/j.ejogrb.2018.09.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30544028"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30544028"}]}]}]}