KRTAP4-7 Gene

HGNC Family Keratin associated proteins (KRTAP)
Name keratin associated protein 4-7
Description This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the ultrahigh sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. [provided by RefSeq, Mar 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n KRTAP4‐7, a member of the keratin‐associated protein family, appears to play a key role in the structural organization and differentiation of hair fibers. Studies evaluating the early phases of hair follicle stress responses have shown that a broad set of keratin‐associated protein genes are upregulated during pathways that lead to terminal differentiation—and KRTAP4‐7 is one such component implicated in this reorganization."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, quantitative phosphorylation proteomic analyses in skin samples from Tan sheep have revealed that the phosphorylation level of KAP4.7 (the protein product of KRTAP4‐7) varies significantly between developmental stages. This suggests that posttranslational modifications of KRTAP4‐7, potentially tied to cysteine and methionine metabolism, contribute to the formation and specific properties of the hair shaft or fur."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Together, these findings support a model in which KRTAP4‐7 is not only integral in providing mechanical support and structural stability to hair fibers but may also be a regulatory target during hair development and in response to stress or external insults.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tatyana Y Sharova, Krzysztof Poterlowicz, Natalia V Botchkareva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Complex changes in the apoptotic and cell differentiation programs during initiation of the hair follicle response to chemotherapy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/jid.2014.267"}], "href": "https://doi.org/10.1038/jid.2014.267"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24999588"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24999588"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yonghong Chen, Dongqian He, Yachao Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A study of the phosphorylation proteomic skin characteristics of Tan sheep during the newborn and er-mao stages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Trop Anim Health Prod (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11250-021-02899-6"}], "href": "https://doi.org/10.1007/s11250-021-02899-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34964062"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34964062"}]}]}]}
Synonyms KAP4.7, KRTAP4.7
Proteins KRA47_HUMAN
NCBI Gene ID 100132476
API
Download Associations
Predicted Functions View KRTAP4-7's ARCHS4 Predicted Functions.
Co-expressed Genes View KRTAP4-7's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View KRTAP4-7's ARCHS4 Predicted Functions.

Functional Associations

KRTAP4-7 has 1,106 functional associations with biological entities spanning 7 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 42 datasets.

Click the + buttons to view associations for KRTAP4-7 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
BioGPS Cell Line Gene Expression Profiles cell lines with high or low expression of KRTAP4-7 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
BioGPS Human Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of KRTAP4-7 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of KRTAP4-7 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of KRTAP4-7 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CCLE Cell Line Gene Expression Profiles cell lines with high or low expression of KRTAP4-7 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of KRTAP4-7 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of KRTAP4-7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ChEA Transcription Factor Targets 2022 transcription factors binding the promoter of KRTAP4-7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
CM4AI KOLF21J CRISPRi Gene Perturbation Atlas gene perturbations changing expression of KRTAP4-7 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
CMAP Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of KRTAP4-7 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores cellular components containing KRTAP4-7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of KRTAP4-7 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene Mutation Profiles cell lines with KRTAP4-7 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with KRTAP4-7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at KRTAP4-7 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of KRTAP4-7 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of KRTAP4-7 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GDSC Cell Line Gene Expression Profiles cell lines with high or low expression of KRTAP4-7 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing KRTAP4-7 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of KRTAP4-7 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations kinase perturbations changing expression of KRTAP4-7 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of KRTAP4-7 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of KRTAP4-7 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of KRTAP4-7 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of KRTAP4-7 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of KRTAP4-7 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles cell lines with high or low expression of KRTAP4-7 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of KRTAP4-7 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of KRTAP4-7 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of KRTAP4-7 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures small molecule perturbations changing expression of KRTAP4-7 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset.
LOCATE Predicted Protein Localization Annotations cellular components predicted to contain KRTAP4-7 protein from the LOCATE Predicted Protein Localization Annotations dataset.
MiRTarBase microRNA Targets microRNAs targeting KRTAP4-7 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of KRTAP4-7 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations gene perturbations changing expression of KRTAP4-7 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of KRTAP4-7 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
Reactome Pathways 2024 pathways involving KRTAP4-7 protein from the Reactome Pathways 2024 dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at KRTAP4-7 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
Rummagene Transcription Factor Associations 2026 transcription factors regulating expression of KRTAP4-7 gene from the Rummagene Transcription Factor Associations 2026 dataset.
TargetScan Predicted Nonconserved microRNA Targets microRNAs regulating expression of KRTAP4-7 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of KRTAP4-7 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores tissues with high expression of KRTAP4-7 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset.