{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Although neither study explicitly focuses on KRTAP5‐11, insights from the two abstracts help frame a potential role for this gene. KRTAP5‐11 belongs to the keratin‐associated protein family, which traditionally is implicated in the structural organization of keratin‐rich tissues. In the context of ciliary biology, the proteomic study (1) uncovers a high‐resolution landscape of ciliary proteins and their interactions. Given that cilia rely on a well‐organized cytoskeletal framework and coordinated vesicle transport for proper assembly and signaling, KRTAP5‐11 may contribute to the structural or regulatory network underpinning ciliogenesis and proteostasis. Similarly, the genome‐wide association study in breast cancer (2) highlights the importance of accurately mapping genetic risk to target genes. Should KRTAP5‐11 be among the candidate genes, its role in maintaining or modulating epithelial cell structure might influence disease risk or prognosis by affecting cellular organization and intracellular signaling networks.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these studies suggest that while KRTAP5‐11 is not directly characterized, its membership in a family of structural proteins positions it as a potential modulator of key cellular processes—including those related to ciliary function and epithelial cell integrity—that may be perturbed in genetic diseases and cancer."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Karsten Boldt, Jeroen van Reeuwijk, Qianhao Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An organelle-specific protein landscape identifies novel diseases and molecular mechanisms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms11491"}], "href": "https://doi.org/10.1038/ncomms11491"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27173435"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27173435"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Joseph S Baxter, Olivia C Leavy, Nicola H Dryden, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Capture Hi-C identifies putative target genes at 33 breast cancer risk loci."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-018-03411-9"}], "href": "https://doi.org/10.1038/s41467-018-03411-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29531215"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29531215"}]}]}]}