{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Keratin‐associated protein 5‐4 (KRTAP5‐4) is a member of the keratin‐associated protein family that plays diverse structural and regulatory roles across different species. In sheep, KRTAP5‐4 encodes a protein integral to the formation of wool fibers; allelic variations in this gene—including non‐synonymous nucleotide changes and length polymorphisms that affect cysteine content—are likely to influence the structural properties of the wool and, consequently, wool traits."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the context of human disease, KRTAP5‐4 mRNA has been detected within serum exosomes and, when combined with other markers, shows promise as a non‐invasive biomarker for the detection of colorectal cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Furthermore, in rice, a gene homologous to the KRTAP5‐4 family—qPE9‐1—has been identified as a key regulator of plant architecture; functional qPE9‐1 alleles contribute to drooping panicles, whereas loss‐of‐function mutations result in erect panicles that are associated with modifications in panicle and grain characteristics, thereby affecting grain yield and suggesting an important role in the domestication process."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hua Gong, Huitong Zhou, Jeffrey E Plowman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of variation in the ovine ultra-high sulphur keratin-associated protein KAP5-4 gene using PCR-SSCP technique."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Electrophoresis (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/elps.201000301"}], "href": "https://doi.org/10.1002/elps.201000301"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20872415"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20872415"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Lei Dong, Wanrun Lin, Peng Qi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating Long RNAs in Serum Extracellular Vesicles: Their Characterization and Potential Application as Biomarkers for Diagnosis of Colorectal Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Epidemiol Biomarkers Prev (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1055-9965.EPI-16-0006"}], "href": "https://doi.org/10.1158/1055-9965.EPI-16-0006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27197301"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27197301"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yong Zhou, Jinyan Zhu, Zhengyi Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deletion in a quantitative trait gene qPE9-1 associated with panicle erectness improves plant architecture during rice domestication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genetics (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1534/genetics.109.102681"}], "href": "https://doi.org/10.1534/genetics.109.102681"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19546322"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19546322"}]}]}]}