{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In a recent organelle‐focused proteomic study (1), an extensive network of ciliary proteins was mapped using affinity proteomics, genetics, and cell biology. Although the study primarily addressed the overall interactome of the cilium—including proteins involved in vesicle transport, cytoskeletal dynamics, signaling, and ubiquitination—it also identified several proteins not previously associated with ciliary functions. Among these, KRTAP9‑6 (keratin‐associated protein 9‑6) emerged as a candidate component of the ciliary proteome. While its canonical role is linked to keratin networks in other cell types, its identification in the ciliary protein landscape suggests that KRTAP9‑6 may contribute to the structural organization or regulatory mechanisms underlying ciliary signaling and proteostasis. Its association with sub‐complexes, such as those related to intraflagellar transport and vesicular trafficking, implies that KRTAP9‑6 might help integrate cytoskeletal elements with ciliary functions. This finding expands our understanding of the molecular machinery present in cilia and opens up new avenues for exploring how perturbations in such proteins could relate to ciliary dysfunction and associated genetic diseases.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n (1)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Karsten Boldt, Jeroen van Reeuwijk, Qianhao Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An organelle-specific protein landscape identifies novel diseases and molecular mechanisms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms11491"}], "href": "https://doi.org/10.1038/ncomms11491"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27173435"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27173435"}]}]}]}