{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Kynurenine aminotransferase 1 (KYAT1), also known as cysteine conjugate β‐lyase 1, is a bifunctional, pyridoxal 5′‐phosphate–dependent enzyme that plays dual roles in cellular metabolism. First, it catalyzes the irreversible transamination of L‐kynurenine to form kynurenic acid (KYNA), a neuroactive metabolite that antagonizes N‐methyl‐D‐aspartate (NMDA) and α7‐nicotinic acetylcholine receptors, thereby contributing to neuroprotection and the regulation of excitatory neurotransmission. Second, KYAT1 is involved in the metabolism of Se‐methylselenocysteine by performing both transamination and β‐elimination reactions to produce methylselenol—a compound implicated in redox modulation and with potential cytotoxic effects against tumor cells. Alterations in KYAT1 activity or expression have been associated with neuropsychiatric conditions such as schizophrenia and movement disorders, as well as with strategies for targeted cancer therapy, underscoring its significance in both central nervous system homeostasis and peripheral metabolic pathways. Collectively, KYAT1’s multifaceted catalytic functions offer potential targets for therapeutic intervention in diseases driven by dysregulated tryptophan catabolism and selenium metabolism."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Arun Kumar Selvam, Mikael Björnstedt "}, {"type": "b", "children": [{"type": "t", "text": "A Novel Assay Method to Determine the β-Elimination of Se-Methylselenocysteine to Monomethylselenol by Kynurenine Aminotransferase 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Antioxidants (Basel) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/antiox9020139"}], "href": "https://doi.org/10.3390/antiox9020139"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32033380"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32033380"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Arthur J L Cooper "}, {"type": "b", "children": [{"type": "t", "text": "The role of glutamine transaminase K (GTK) in sulfur and alpha-keto acid metabolism in the brain, and in the possible bioactivation of neurotoxicants."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurochem Int (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuint.2003.12.002"}], "href": "https://doi.org/10.1016/j.neuint.2003.12.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15016471"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15016471"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ranjna Kapoor, Kelly Sy Lim, Alice Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Preliminary evidence for a link between schizophrenia and NMDA-glycine site receptor ligand metabolic enzymes, d-amino acid oxidase (DAAO) and kynurenine aminotransferase-1 (KAT-1)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Res (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.brainres.2006.05.082"}], "href": "https://doi.org/10.1016/j.brainres.2006.05.082"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16828464"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16828464"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Zsuzsanna Hartai, Peter Klivenyi, Tamas Janaky, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Peripheral kynurenine metabolism in focal dystonia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2174/157340607780620707"}], "href": "https://doi.org/10.2174/157340607780620707"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17504201"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17504201"}]}]}]}