{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nLysosome‐associated protein transmembrane 4 beta (LAPTM4B) has emerged as a multifunctional regulator of lysosomal activity and intracellular signaling. Early studies demonstrated that LAPTM4B facilitates the recruitment of amino acid transporters to lysosomes, thereby promoting leucine uptake and activating mTORC1 in response to essential amino acids."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In parallel, LAPTM4B modulates endosomal receptor trafficking—by impeding the ubiquitination of sorting proteins, it delays EGFR degradation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "—and interacts with partners in regulatory T cells to temper TGF‐β production."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, LAPTM4B is critical for lysosome homeostasis; it sustains autophagic flux and exosome secretion by maintaining membrane integrity and facilitating ceramide export from late endosomal compartments"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in cell homeostasis, LAPTM4B overexpression is a common feature in numerous malignancies where it drives oncogenic processes. Elevated LAPTM4B promotes cell proliferation, migration, invasion, and multidrug resistance—partly through its physical association with efflux transporters and activation of the PI3K/AKT pathway"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " In breast and ovarian carcinomas, high LAPTM4B levels correlate with aggressive tumor behavior and poor clinical outcome—a link further reinforced by findings that oncogenic transcription factors such as CREB1 and AP4 directly upregulate LAPTM4B expression"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": " Similar oncogenic roles have been documented in non‐small cell lung cancer—where LAPTM4B upregulation is linked to smoking and an enhanced NRF2 stress response"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": "—as well as in gliomas, cervical carcinomas, and metastatic breast cancers, where its overexpression signals tumor aggressiveness and resistance to therapy"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "22"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "23"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nGenetic and clinical profiling studies further underscore the importance of LAPTM4B as both a cancer susceptibility gene and a prognostic marker. Polymorphisms—most notably a tandem duplication in its 5′ untranslated region—have been significantly associated with increased risk of hepatocellular, gastric, colorectal, gallbladder, lung, and other carcinomas"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "24"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "25"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "26"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "27"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "28"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "29"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "30"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "31"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "32"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "33"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "34"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "35"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "36"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "37"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "38"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "39"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "40"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "41"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "42"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "43"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "44"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "45"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "46"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "47"}]}, {"type": "t", "text": " In addition, early investigations and expanded expression profiling have also hinted at potential roles for LAPTM4B in other disease settings—including alterations in the tissue microenvironment seen in adolescent idiopathic scoliosis—and reinforced its utility as a marker for tumor progression and patient prognosis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "48"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "49"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "50"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ruth Milkereit, Avinash Persaud, Liviu Vanoaica, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Lysosomal transmembrane protein LAPTM4B promotes autophagy and tolerance to metabolic stress in cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-11-0940"}], "href": "https://doi.org/10.1158/0008-5472.CAN-11-0940"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22037872"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22037872"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Tomas Blom, Shiqian Li, Andrea Dichlberger, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "LAPTM4B: a novel cancer-associated gene motivates multidrug resistance through efflux and activating PI3K/AKT signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2010.303"}], "href": "https://doi.org/10.1038/onc.2010.303"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20711237"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20711237"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Hongtuan Zhang, Shiyong Qi, Tao Zhang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "The Transcription Factor AP4 Promotes Oncogenic Phenotypes and Cisplatin Resistance by Regulating "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "LAPTM4B"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-17-0519"}], "href": "https://doi.org/10.1158/1541-7786.MCR-17-0519"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29378908"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29378908"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Han Tang, Hui Tian, Weiming Yue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of LAPTM4B is correlated with tumor angiogenesis and poor prognosis in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Oncol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12032-014-0974-8"}], "href": "https://doi.org/10.1007/s12032-014-0974-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24816841"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24816841"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Yuho Maki, Junya Fujimoto, Wenhua Lang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LAPTM4B is associated with poor prognosis in NSCLC and promotes the NRF2-mediated stress response pathway in lung cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep13846"}], "href": "https://doi.org/10.1038/srep13846"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26343532"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26343532"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Xiaoshud Dong, Kaoru Tamura, Daisuke Kobayashi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LAPTM4B-35 is a novel prognostic factor for glioblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurooncol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11060-017-2369-0"}], "href": "https://doi.org/10.1007/s11060-017-2369-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28097442"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28097442"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Min Xiao, Shanshan Yang, FanLing Meng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LAPTM4B Predicts Axillary Lymph Node Metastasis in Breast Cancer and Promotes Breast Cancer Cell Aggressiveness in Vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000464115"}], "href": "https://doi.org/10.1159/000464115"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28245476"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28245476"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Yu Yang, Hua Yang, Michael A McNutt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LAPTM4B overexpression is an independent prognostic marker in ovarian carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2008)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18949404"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18949404"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Fanling Meng, Chang Luo, Yuanlong Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of LAPTM4B-35 in cervical carcinoma: a clinicopathologic study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Gynecol Pathol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/PGP.0b013e3181e0898e"}], "href": "https://doi.org/10.1097/PGP.0b013e3181e0898e"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20881850"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20881850"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Fanling Meng, Xiuwei Chen, Hongtao Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LAPTM4B down regulation inhibits the proliferation, invasion and angiogenesis of HeLa cells in vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000430216"}], "href": "https://doi.org/10.1159/000430216"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26383850"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26383850"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Hongying Zhang, Buxian Tian, Hongyu Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LAPTM4B-35 protein as a potential therapeutic target in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-014-2599-0"}], "href": "https://doi.org/10.1007/s13277-014-2599-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25416438"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25416438"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Xin-Rong Liu, Rou-Li Zhou, Qing-Yun Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure analysis and expressions of a novel tetratransmembrane protein, lysosoma-associated protein transmembrane 4 beta associated with hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Gastroenterol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3748/wjg.v10.i11.1555"}], "href": "https://doi.org/10.3748/wjg.v10.i11.1555"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15162524"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15162524"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Grit Kasper, Anke Vogel, Irina Klaman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The human LAPTM4b transcript is upregulated in various types of solid tumours and seems to play a dual functional role during tumour progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2004.10.004"}], "href": "https://doi.org/10.1016/j.canlet.2004.10.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15911104"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15911104"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Li-juan Deng, Qing-yun Zhang, Bo Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Relationship between LAPTM4B gene polymorphism and susceptibility of lung cancer]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Beijing Da Xue Xue Bao Yi Xue Ban (2005)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15968325"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15968325"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Y Liu, Q-Y Zhang, N Qian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Relationship between LAPTM4B gene polymorphism and susceptibility of gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Oncol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/annonc/mdl394"}], "href": "https://doi.org/10.1093/annonc/mdl394"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17074969"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17074969"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "X-J Cheng, W Xu, Q-Y Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Relationship between LAPTM4B gene polymorphism and susceptibility of colorectal and esophageal cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Oncol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/annonc/mdm469"}], "href": "https://doi.org/10.1093/annonc/mdm469"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17965115"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17965115"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Li Zhou, Xiao-Dong He, Quan-Cai Cui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of LAPTM4B-35: a novel marker of progression, invasiveness and poor prognosis of extrahepatic cholangiocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2008.01.025"}], "href": "https://doi.org/10.1016/j.canlet.2008.01.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18334282"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18334282"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Hua Yang, Fu Xia Xiong, Ming Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LAPTM4B-35 overexpression is a risk factor for tumor recurrence and poor prognosis in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer Res Clin Oncol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00432-009-0659-4"}], "href": "https://doi.org/10.1007/s00432-009-0659-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19690886"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19690886"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Hua Yang, Fuxia Xiong, Ruizhao Qi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LAPTM4B-35 is a novel prognostic factor of hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Surg Oncol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jso.21489"}], "href": "https://doi.org/10.1002/jso.21489"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20358632"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20358632"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Mingzhu Yin, Cong Li, Xia Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Over-expression of LAPTM4B is associated with poor prognosis and chemotherapy resistance in stages III and IV epithelial ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Surg Oncol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jso.21912"}], "href": "https://doi.org/10.1002/jso.21912"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21416470"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21416470"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Li Zhou, Xiao-Dong He, Jian-Chun Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of LAPTM4B-35 attenuates epirubucin-induced apoptosis of gallbladder carcinoma GBC-SD cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Surgery (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.surg.2010.12.010"}], "href": "https://doi.org/10.1016/j.surg.2010.12.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21429547"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21429547"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Li Li, Yi Shan, Hua Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of LAPTM4B-35 promotes malignant transformation and tumorigenesis in L02 human liver cell line."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anat Rec (Hoboken) (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ar.21421"}], "href": "https://doi.org/10.1002/ar.21421"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21618708"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21618708"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Fanling Meng, Hongtao Song, Chang Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Correlation of LAPTM4B polymorphisms with cervical carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cncr.25833"}], "href": "https://doi.org/10.1002/cncr.25833"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21656743"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21656743"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "S Wang, Q-Y Zhang, R-L Zhou "}, {"type": "b", "children": [{"type": "t", "text": "Relationship between LAPTM4B gene polymorphism and susceptibility of primary liver cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Oncol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/annonc/mdr538"}], "href": "https://doi.org/10.1093/annonc/mdr538"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22156622"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22156622"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Mingzhu Yin, Chun Lou, Wang Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LAPTM4B overexpression is a novel independent prognostic marker for metastatic ovarian tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Gynecol Cancer (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/IGC.0b013e318234f9ac"}], "href": "https://doi.org/10.1097/IGC.0b013e318234f9ac"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22193644"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22193644"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Guojun Zhai, Hua Yang, Xiaoxu Ji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Correlation of LAPTM4B polymorphisms with hepatocellular carcinoma in Chinese patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Oncol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12032-011-0139-y"}], "href": "https://doi.org/10.1007/s12032-011-0139-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22207410"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22207410"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Meirong Fan, Ye Liu, Rouli Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of LAPTM4B gene polymorphism with breast cancer susceptibility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Epidemiol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canep.2011.12.004"}], "href": "https://doi.org/10.1016/j.canep.2011.12.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22270081"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22270081"}]}, {"type": "r", "ref": 40, "children": [{"type": "t", "text": "Hua Yang, Guojun Zhai, Xiaoxu Ji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Correlation of LAPTM4B polymorphisms with gallbladder carcinoma susceptibility in Chinese patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Oncol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12032-012-0173-4"}], "href": "https://doi.org/10.1007/s12032-012-0173-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22302286"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22302286"}]}, {"type": "r", "ref": 41, "children": [{"type": "t", "text": "Ye Xu, Yunduo Liu, Rouli Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LAPTM4B polymorphisms is associated with ovarian cancer susceptibility and its prognosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Jpn J Clin Oncol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jjco/hys026"}], "href": "https://doi.org/10.1093/jjco/hys026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22412199"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22412199"}]}, {"type": "r", "ref": 42, "children": [{"type": "t", "text": "Hua Yang, Guojun Zhai, Xiaoxu Ji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LAPTM4B allele *2 is a marker of poor prognosis following hepatic tumor resection for hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0034984"}], "href": "https://doi.org/10.1371/journal.pone.0034984"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22509374"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22509374"}]}, {"type": "r", "ref": 43, "children": [{"type": "t", "text": "Yue Kang, Mingzhu Yin, Wei Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of LAPTM4B-35 is associated with poor prognosis in colorectal carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Surg (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.amjsurg.2012.02.003"}], "href": "https://doi.org/10.1016/j.amjsurg.2012.02.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22578410"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22578410"}]}, {"type": "r", "ref": 44, "children": [{"type": "t", "text": "G Zhang, Y Liang, Y Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elevated lysosome-associated protein transmembrane-4β-35 is an independent prognostic marker in pancreatic carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Int Med Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/147323001204000406"}], "href": "https://doi.org/10.1177/147323001204000406"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22971479"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22971479"}]}, {"type": "r", "ref": 45, "children": [{"type": "t", "text": "Xiaoyan Li, Xiangnan Kong, Xi Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LAPTM4B allele *2 is associated with breast cancer susceptibility and prognosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0044916"}], "href": "https://doi.org/10.1371/journal.pone.0044916"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22984585"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22984585"}]}, {"type": "r", "ref": 46, "children": [{"type": "t", "text": "Bing Wang, Jianjun Xu, Rouli Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of LAPTM4B gene polymorphism with nasopharyngeal carcinoma susceptibility in a Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Oncol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12032-013-0470-6"}], "href": "https://doi.org/10.1007/s12032-013-0470-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23345117"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23345117"}]}, {"type": "r", "ref": 47, "children": [{"type": "t", "text": "Xiaojing Cheng, Zhixue Zheng, Zhaode Bu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LAPTM4B-35, a cancer-related gene, is associated with poor prognosis in TNM stages I-III gastric cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0121559"}], "href": "https://doi.org/10.1371/journal.pone.0121559"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25849595"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25849595"}]}, {"type": "r", "ref": 48, "children": [{"type": "t", "text": "Humam Kadara, Junya Fujimoto, Suk-Young Yoo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptomic architecture of the adjacent airway field cancerization in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Natl Cancer Inst (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jnci/dju004"}], "href": "https://doi.org/10.1093/jnci/dju004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24563515"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24563515"}]}, {"type": "r", "ref": 49, "children": [{"type": "t", "text": "Eun Su Moon, Hak Sun Kim, Veushj Sharma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of single nucleotide polymorphism in adolescent idiopathic scoliosis in Korea: for personalized treatment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Yonsei Med J (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3349/ymj.2013.54.2.500"}], "href": "https://doi.org/10.3349/ymj.2013.54.2.500"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23364988"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23364988"}]}, {"type": "r", "ref": 50, "children": [{"type": "t", "text": "Hongtuan Zhang, Qiang Wei, Ranlu Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of LAPTM4B-35: a novel marker of poor prognosis of prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0091069"}], "href": "https://doi.org/10.1371/journal.pone.0091069"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24651764"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24651764"}]}]}]}