LARS2 Gene

HGNC Family	Aminoacyl tRNA synthetases
Name	leucyl-tRNA synthetase 2, mitochondrial
Description	This gene encodes a class 1 aminoacyl-tRNA synthetase, mitochondrial leucyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nLARS2 encodes the mitochondrial leucyl‐tRNA synthetase, a key enzyme that catalyzes the aminoacylation of mitochondrial tRNA(Leu), essential for proper mitochondrial translation and energy production. Several studies have demonstrated that pathogenic variants in LARS2 disrupt mitochondrial protein synthesis and are strongly linked to Perrault syndrome, a disorder characterized by sensorineural hearing loss and ovarian dysfunction, as well as other neurological manifestations and leukodystrophy. In experimental models, overexpression of LARS2 restored aminoacylation efficiency and improved mitochondrial translation and respiration in cells carrying pathogenic mitochondrial tRNA mutations, underscoring its pivotal role in maintaining mitochondrial function and protein stability."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its central role in mitochondrial translation, aberrant LARS2 function or expression is implicated in broader systemic conditions. Elevated LARS2 levels have been observed in the prefrontal cortex of bipolar disorder patients, linking mitochondrial dysregulation to neuropsychiatric disease. In addition, epigenetic modifications at the LARS2 locus are associated with obesity‐related traits, and specific coding variants (such as H324Q) have been linked to an increased risk of type 2 diabetes, thereby implicating LARS2 in metabolic homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nLARS2 also plays a significant role in modulating cellular function beyond energy production. In granulosa cells, reduced LARS2 expression has been shown to impair mitochondrial integrity, leading to decreased cell proliferation and increased apoptosis, which may underlie premature ovarian insufficiency. Moreover, a distinct subset of immunoregulatory B cells expressing LARS2 has been identified in colorectal cancer, suggesting that LARS2‐mediated mitochondrial aminoacyl-tRNA biosynthesis can influence immune cell phenotype and tumor microenvironment. Further supporting its therapeutic relevance, small peptides derived from LARS2 domains have been proposed to ameliorate mitochondrial dysfunction caused by tRNA mutations, and regulatory pathways involving factors such as Lin28a have been shown to modulate LARS2 levels to control mitochondrial and steroidogenic function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sarah B Pierce, Ksenija Gersak, Rachel Michaelson-Cohen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in LARS2, encoding mitochondrial leucyl-tRNA synthetase, lead to premature ovarian failure and hearing loss in Perrault syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2013.03.007"}], "href": "https://doi.org/10.1016/j.ajhg.2013.03.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23541342"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23541342"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ronghua Li, Min-Xin Guan "}, {"type": "b", "children": [{"type": "t", "text": "Human mitochondrial leucyl-tRNA synthetase corrects mitochondrial dysfunctions due to the tRNALeu(UUR) A3243G mutation, associated with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like symptoms and diabetes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01614-09"}], "href": "https://doi.org/10.1128/MCB.01614-09"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20194621"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20194621"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "L A M Demain, J E Urquhart, J O'Sullivan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expanding the genotypic spectrum of Perrault syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cge.12776"}], "href": "https://doi.org/10.1111/cge.12776"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26970254"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26970254"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hyejeong Park, Edgar Davidson, Michael P King "}, {"type": "b", "children": [{"type": "t", "text": "Overexpressed mitochondrial leucyl-tRNA synthetase suppresses the A3243G mutation in the mitochondrial tRNA(Leu(UUR)) gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "RNA (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1261/rna.1208808"}], "href": "https://doi.org/10.1261/rna.1208808"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18796578"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18796578"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Giulia Soldà, Sonia Caccia, Michela Robusto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "First independent replication of the involvement of LARS2 in Perrault syndrome by whole-exome sequencing of an Italian family."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hum Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/jhg.2015.149"}], "href": "https://doi.org/10.1038/jhg.2015.149"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26657938"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26657938"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Rika Kosaki, Reiko Horikawa, Eriko Fujii, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Biallelic mutations in LARS2 can cause Perrault syndrome type 2 with neurologic symptoms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.38552"}], "href": "https://doi.org/10.1002/ajmg.a.38552"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29205794"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29205794"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Lisa G Riley, Joëlle Rudinger-Thirion, Magali Frugier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The expanding LARS2 phenotypic spectrum: HLASA, Perrault syndrome with leukodystrophy, and mitochondrial myopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.24050"}], "href": "https://doi.org/10.1002/humu.24050"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32442335"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32442335"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Qing Ye, Meng Wang, Zhi-Peng Fang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Degenerate connective polypeptide 1 (CP1) domain from human mitochondrial leucyl-tRNA synthetase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M115.672824"}], "href": "https://doi.org/10.1074/jbc.M115.672824"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26272616"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26272616"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Y B Lei, S P Sun, L Mao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Analysis of perrault syndrome caused by pathogenic variants in "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "LARS2"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " and "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "HARS2"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " genes]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3760/cma.j.cn115330-20230329-00140"}], "href": "https://doi.org/10.3760/cma.j.cn115330-20230329-00140"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38186093"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38186093"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Assia Idyahia, Salaheddine Redouan, Ghita Amalou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exome sequencing reveals pathogenic mutations in the LARS2 and HSD17B4 genes associated with Perrault syndrome and D-bifunctional protein deficiency in Moroccan families."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Rep (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11033-024-09740-x"}], "href": "https://doi.org/10.1007/s11033-024-09740-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39052101"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39052101"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Kae Munakata, Kazuya Iwamoto, Miki Bundo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mitochondrial DNA 3243A>G mutation and increased expression of LARS2 gene in the brains of patients with bipolar disorder and schizophrenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Psychiatry (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopsych.2004.11.041"}], "href": "https://doi.org/10.1016/j.biopsych.2004.11.041"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15737668"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15737668"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Klodian Dhana, Kim V E Braun, Jana Nano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An Epigenome-Wide Association Study of Obesity-Related Traits."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Epidemiol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/aje/kwy025"}], "href": "https://doi.org/10.1093/aje/kwy025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29762635"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29762635"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Leen M 't Hart, Torben Hansen, Ingrid Rietveld, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/diabetes.54.6.1892"}], "href": "https://doi.org/10.2337/diabetes.54.6.1892"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15919814"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15919814"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "E Reiling, B Jafar-Mohammadi, E van 't Riet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic association analysis of LARS2 with type 2 diabetes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetologia (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00125-009-1557-7"}], "href": "https://doi.org/10.1007/s00125-009-1557-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19847392"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19847392"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Zhiqiang Wang, Zhou Lu, Shengli Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Leucine-tRNA-synthase-2-expressing B cells contribute to colorectal cancer immunoevasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2022.04.017"}], "href": "https://doi.org/10.1016/j.immuni.2022.04.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35659337"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35659337"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Hue Tran Hornig-Do, Arianna Montanari, Agata Rozanska, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human mitochondrial leucyl tRNA synthetase can suppress non cognate pathogenic mt-tRNA mutations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Mol Med (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/emmm.201303202"}], "href": "https://doi.org/10.1002/emmm.201303202"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24413189"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24413189"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Marjo S van der Knaap, Marianna Bugiani, Marisa I Mendes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Biallelic variants in "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "LARS2"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " and "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "KARS"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " cause deafness and (ovario)leukodystrophy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurology (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1212/WNL.0000000000007098"}], "href": "https://doi.org/10.1212/WNL.0000000000007098"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30737337"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30737337"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Shujun Feng, Shan Wan, Shuangying Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LARS2 Regulates Apoptosis via ROS-Mediated Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Ovarian Granulosa Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oxid Med Cell Longev (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2022/5501346"}], "href": "https://doi.org/10.1155/2022/5501346"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35585880"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35585880"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Jing Chen, Weimin Liu "}, {"type": "b", "children": [{"type": "t", "text": "Lin28a induced mitochondrial dysfunction in human granulosa cells via suppressing LARS2 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2022.110536"}], "href": "https://doi.org/10.1016/j.cellsig.2022.110536"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36436798"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36436798"}]}]}]}
Synonyms	PRLTS4, LEURS, HLASA, mtLeuRS
Proteins	SYLM_HUMAN
NCBI Gene ID	23395
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

LARS2 has 6,718 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 128 datasets.

Click the + buttons to view associations for LARS2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

LARS2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of LARS2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of LARS2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of LARS2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of LARS2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of LARS2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of LARS2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of LARS2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of LARS2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of LARS2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of LARS2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of LARS2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of LARS2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with LARS2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with LARS2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of LARS2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of LARS2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of LARS2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with LARS2 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with LARS2 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing LARS2 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of LARS2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing LARS2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing LARS2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing LARS2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing LARS2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with LARS2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with LARS2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with LARS2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with LARS2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving LARS2 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with LARS2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with LARS2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with LARS2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with LARS2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with LARS2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for LARS2 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at LARS2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of LARS2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of LARS2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing LARS2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.