{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LCE1F, a member of the late cornified envelope (LCE) gene family, has been characterized as a direct downstream target of the tumor suppressor p53. Upon activation by p53—either through ectopic overexpression or in response to DNA damage—LCE1F expression is upregulated, and a functional p53‐binding enhancer in the LCE1 cluster has been identified. Notably, LCE1F interacts with protein arginine methyltransferase 5 (PRMT5), and its overexpression reduces PRMT5‐mediated symmetric dimethylation of histone H3 at arginine 8. This modulation of histone methylation suggests that LCE1F contributes to tumor suppressor functions by influencing chromatin structure and gene expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the context of epithelial biology, LCE genes—including LCE1F—are typically expressed in the differentiated layers of the epidermis and are critical for barrier formation. Consistent with this role, transcriptomic profiling studies have observed downregulation of late cornified envelope and keratinization genes in certain aggressive cancer subtypes, implying that perturbations in LCE gene expression, including potentially that of LCE1F, may contribute to alterations in differentiation and a loss of protective barrier functions in disease states."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, integrative analyses of transcriptomic datasets have revealed that LCE family genes may also participate in the molecular cross‐talk between distinct pathologies such as periodontitis and hypothyroidism. Although the precise mechanisms remain to be fully elucidated, these findings underscore a broader involvement of LCE genes in epithelial homeostasis and inflammatory or stress responses beyond their established functions in terminal differentiation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these studies suggest that LCE1F not only mediates p53‐dependent tumor suppression through epigenetic regulation but also plays a part in maintaining epithelial integrity. Its dysregulation may contribute to both cancer progression and perturbations in barrier function observed in various inflammatory conditions.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhenzhong Deng, Koichi Matsuda, Chizu Tanikawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Late Cornified Envelope Group I, a novel target of p53, regulates PRMT5 activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasia (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neo.2014.07.008"}], "href": "https://doi.org/10.1016/j.neo.2014.07.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25220593"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25220593"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jasmine A McQuerry, David F Jenkins, Susan E Yost, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pathway activity profiling of growth factor receptor network and stemness pathways differentiates metaplastic breast cancer histological subtypes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-019-6052-z"}], "href": "https://doi.org/10.1186/s12885-019-6052-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31488082"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31488082"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Bin Yan, Fukai Ren, Wei Shang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptomic Analysis Reveals Genetic Cross-Talk between Periodontitis and Hypothyroidism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dis Markers (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2022/5736394"}], "href": "https://doi.org/10.1155/2022/5736394"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35450027"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35450027"}]}]}]}