{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Ligand‐dependent corepressor (LCOR) functions as a multifaceted transcriptional repressor that is recruited to agonist‐bound nuclear receptors through a conserved LXXLL motif. By engaging histone deacetylases and C‐terminal binding proteins, LCOR attenuates receptor‐dependent transactivation, as exemplified by its ability to inhibit estrogen receptor– and progesterone receptor–mediated gene expression in breast cancer cells ["}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "]. In addition, LCOR interacts with other transcription factors such as KLF6 to repress target genes involved in cell cycle regulation and cell adhesion ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "]. In contexts beyond classical nuclear receptor signaling, LCOR has been shown to “prime” interferon responses in mammary stem cells and breast cancer stem cells; its downregulation by miR‐199a preserves stem cell properties by protecting cells from interferon‐induced differentiation and senescence ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "]. Moreover, LCOR forms part of a regulatory axis in mouse bone marrow stromal stem cells where its expression is modulated by a long noncoding RNA (H19) and miR‐188; here, LCOR promotes osteogenic differentiation while suppressing adipogenic fate ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "]. In prostate cancer cells, LCOR functions as an androgen receptor corepressor, and its ability to inhibit androgen‐induced transcription can be counteracted by oncogenic signals (e.g. Src kinase activity) that diminish its repressive influence, thereby contributing to disease progression ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "]. Furthermore, in splenic macrophages, LCOR expression is negatively regulated by miR‐615-3p; the consequent reduction in LCOR levels leads to derepression of PPARγ, which in turn enhances the phagocytic capacity of these cells ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "]. LCOR has also been identified as part of a non‐canonical Wnt target gene signature in colon cancer cells, suggesting that its expression may be governed by alternative signaling pathways beyond nuclear receptor modulation ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "]. Finally, differential expression of LCOR in breast tumors, particularly when considered jointly with other coregulators such as RIP140, appears to correlate with clinical outcome, underscoring its potential relevance as a prognostic marker ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "].\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Isabelle Fernandes, Yolande Bastien, Timothy Wai, et al. 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